Abstract:The protein hormone insulin, produced in the pancreas and stored in granules, interacts, after secretion into the blood stream, with the extracellular domain of the insulin receptor. This interaction initializes a signal transduction cascade that ultimately results in glucose absorption and metabolism. In the presence of zinc ion, insulin crystallizes as a threefold symmetric T
6
hexamer complexed to two zinc ions. When phenol,
m
‐cresol, or resorcinol is present… Show more
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