Insuficiencia renal aguda por linfoma de Burkitt renal primario bilateral

Renal Infiltration as a Primary Presentation of Burkitt Lymphoma Secondary to Systemic Lupus Erythematosus: A Rarity Unto a Rarity

“…Renal infiltration by lymphoid cells as initial manifestation of acute renal failure (ARF) is a rare cause [6,7,9]. In the autopsy of non-Hodgkin lymphoma patients, the incidence of renal involvement was 30-50% (that was clinically silent with no symptoms), out of which only 0.9-23% developed renal insufficiency [5].…”

“…In the autopsy of non-Hodgkin lymphoma patients, the incidence of renal involvement was 30-50% (that was clinically silent with no symptoms), out of which only 0.9-23% developed renal insufficiency [5]. Seven cases of Burkitt lymphoma presenting as ARF [4][5][6][7][8][9][10] have been listed in the literature so far, whereas only one case had been reported where a patient with SLE [12] also developed BL.…”

“…The development of BL is dependent on the constitutive expression of the MYC proto-oncogene located at chromosome 8q24, which encodes the MYC [ 1 - 3 ] protein transcription factor V. This transcription factor modulates the expression of target genes that regulate many cell processes including cell growth and division, immortalization, Warburg metabolism (modified cellular metabolism in cancer cells), and cell death by apoptosis. In 1958, an English surgeon, Burkitt, described the respective lymphoma as a highly aggressive non-Hodgkin B-cell lymphoma that resembles acute lymphoblastic leukemia subtype L3 (classification of the tumor according to the shape of cells and nucleus) [ 2 , 4 , 6 , 7 ]. It commonly affects male children between four and eight years of age, but it can occur at any age [ 1 , 4 ].…”

“…Renal failure seen in patients of non-Hodgkin lymphoma could be due to acute tumor lysis syndrome, urinary obstruction, or urate nephropathy [3][4][5][6], but diffuse bilateral kidney infiltration as a cause of AKI is a rare cause. Only a few cases have been reported in the literature [4][5][6][7][8][9][10].…”

A Pediatric Renal Lymphoma Case Presenting with Central Nervous System Findings

“…Renal insufficiency associated with tumor lysis syndrome is a frequent complication that clinicians must be aware of [6,7,8]. Bilateral primary renal NHL is an extremely rare condition in the pediatric age group and only a few cases have been reported in the English-language medical literature [9,10,11,12]. Primary renal NHL generally presents with an abdominal mass, as in the presented case, but renal failure, hematuria, and anemia have also been described [13,14].…”