Insufficient recovery of monoamine oxidase in a bioequivalence study of the monoamine oxidase inhibitor tranylcypromine: Recommendation of the tranylcypromine enantiomer test

Enantiomer Plasma Concentrations of Tranylcypromine as a Test for Peripheral Monoamine Oxidase Inhibition

“…The details of sample preparation, LC separation, MS/MS analysis, and method validation have been described in previous studies. 5 A typical course of enantiomer plasma concentrations of TCP is shown in Figure 1. During the first single dose, (+)-TCP was extremely low compared with (2)-TCP, with enantiomer ratios of approximately 0.1 (C max,(+)-TCP / C max,(2)-TCP = 0.06-0.22, AUC 0-8h,(+)-TCP /AUC 0-8h,(2)-TCP = 0.04-0.16).…”

“…3 Because the oxidative metabolism of ethanol by the fetus is limited, it is likely that the nonoxidative pathway is more important for its excretion. The presence of mature UDP-glucuronosyltransferases 4 and sulfotransferases in the fetus 5 as early as 20 weeks of gestation and the elimination of EtG and EtS, mainly by the renal pathway, may explain the accumulation of these minor metabolites in the AF. Because red blood cells are not usually present in sufficient amounts in this matrix, the absence of PEth in the AF was expected.…”

“…1 Plasma concentrations of (+)-TCP are considerably lower than those of (−)-TCP after a single dose of racemic TCP or after equal doses of the pure enantiomers. 2–5 In a sequential application of escalating schemes of equal doses of TCP enantiomers, each for 3 days, plasma concentrations of (−)-TCP were lower compared with those of (+)-TCP. However, this was investigated in one blood sample alone, taken 2.5 hours after the dose.…”

“…The details of sample preparation, LC separation, MS/MS analysis, and method validation have been described in previous studies. 5…”

Psychopharmakotherapie mit dem MAO-Hemmer Tranylcypromin Schwerpunkte und Trends aus Theorie und Praxis

“…Die irreversiblen MAO-B-Hemmer Selegilin und Rasagilin sowie der reversible MAO-B-Hemmer Safinamid stehen außerdem in der Neurologie zur Behandlung des M. Parkinson zur Verfügung 1 2 3 . In pflanzlichen Präparaten aus Steppenraute (Peganum harmala) und der Ayahuasca-Liane (Banisteriopsis caapi) der Naturmedizin verschiedener Kulturen ist der reversible MAO-A-Hemmer Harmin (auch Banistrin genannt) pharmakologische Leitsubstanz 4 .…”