Insufficient Radiofrequency Ablation Treated Hepatocellular Carcinoma Cells Promote Metastasis by Up-Regulation ITGB3

Zhang, Ning; Ma, Dongjie; Wang, Lu; Zhu, Xiao‐Dong; Pan, Qi; Zhao, Yiming; Zhu, Weiping; Zhou, Jiamin; Wang, Longrong; Chai, Zong‐Tao; Ao, Jian‐Yang; Sun, Hui‐Chuan; Tang, Zhao–You

doi:10.7150/jca.20816

Cited by 31 publications

(30 citation statements)

References 46 publications

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“…A previous study reported that activation of ITGB1 signaling dramatically enhanced cell proliferation and invasion in HCC [49]. The similar effect has been examined on ITGB3 [50], ITGB4 [51], ITGB5 [52], ITGA1 [53], ITGA2 [54], ITGA5 [55], ITGA6 [56], ITGA7 [57] in HCC. However, it was worth noting that a recent study found that overexpression of ITGA3 can attenuate the proliferation of HCC cells regulated by LAMB3, and the inhibitory roles have also been reported on ITGA9 in HCC [58].…”

Section: Discussionmentioning

confidence: 59%

PRELP has prognostic value and regulates cell proliferation and migration in hepatocellular carcinoma

Hong

Niu

et al. 2020

J. Cancer

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Purpose: Hepatocellular carcinoma (HCC) is an aggressive and prevalent tumor threatening human health. A previous study suggested low PRELP (proline/arginine-rich end leucine-rich repeat protein) expression was associated with poor patient survival in pancreatic ductal adenocarcinoma (PDAC). However, the role of PRELP in HCC has not yet been illuminated. Methods: PRELP expression analyses were carried out using transcriptomic datasets from the Integrative Molecular Database of Hepatocellular Carcinoma (HCCDB). The correlations between PRELP expression and clinicopathological features, and prognostic analyses were performed with a tissue microarray (TMA) and immunohistochemistry (IHC). The endogenous expression and in vitro roles of PRELP were investigated in cultured HCC cell lines. The potential mechanisms were characterized by a Gene Set Enrichment Analysis (GSEA) and gene-gene correlation analyses. Results: We found that PRELP mRNA expression was dramatically decreased in HCCs in comparison with that in adjacent normal tissues (NTs) or hepatic cirrhosis. IHC staining showed that PRELP was down-regulated in HCCs, which mainly located in cytoplasm, and was also found in nuclei. The correlation analyses revealed that PRELP expression was relevant to later p-stages (p= 0.028) and tumor size (p= 0.001). The overall survival (OS) and relapse free survival (RFS) time was shorter in HCC patients with lower PRELP expression levels than that with higher PRELP expression levels. Overexpression of PRELP inhibited, while knockdown of PRELP promoted proliferation and migration of HCC cells. For potential mechanisms, PRELP may inhibit progression of HCCs by interacting with integrin family members and the extracellular microenvironment. Conclusion: Our findings demonstrated that overexpression of PRELP correlates with better patient survival and inhibits both cell proliferation and migration in HCC. Therefore, PRELP can serve as a potential prognostic biomarker and therapeutic target which deserves further investigation.

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Section: Discussionmentioning

confidence: 59%

PRELP has prognostic value and regulates cell proliferation and migration in hepatocellular carcinoma

Hong

Niu

et al. 2020

J. Cancer

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“…ITGB3 has been reported to promote tumorigenesis by activating the FAK/PI3K/Akt pathway (26,27). Therefore, we investigated the ability of modulation of the FAM225A-miR-590-3p/miR-1275-ITGB3 axis to influence FAK/ PI3K/Akt pathway activation.…”

Section: Fam225a Decoys Mir-590-3p and Mir-1275 To Upregulate Their Cmentioning

confidence: 99%

Long Noncoding RNA FAM225A Promotes Nasopharyngeal Carcinoma Tumorigenesis and Metastasis by Acting as ceRNA to Sponge miR-590-3p/miR-1275 and Upregulate ITGB3

et al. 2019

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Long noncoding RNAs (lncRNA) play important roles in the tumorigenesis and progression of cancers. However, the clinical significance of lncRNAs and their regulatory mechanisms in nasopharyngeal carcinogenesis (NPC) are largely unknown. Here, based on a microarray analysis, we identified 384 dysregulated lncRNAs, of which, FAM225A was one of the most upregulated lncRNAs in NPC. FAM225A significantly associated with poor survival in NPC. N(6)-Methyladenosine (m6A) was highly enriched within FAM225A and enhanced its RNA stability. FAM225A functioned as an oncogenic lncRNA that promoted NPC cell proliferation, migration, invasion, tumor growth, and metastasis. Mechanistically, FAM225A functioned as a competing endogenous RNA (ceRNA) for sponging miR-590-3p and miR-1275, leading to the upregulation of their target integrin b3 (ITGB3), and the activation of FAK/PI3K/Akt signaling to promote NPC cell proliferation and invasion. In summary, our study reveals a potential ceRNA regulatory pathway in which FAM225A modulates ITGB3 expression by binding to miR-590-3p and miR-1275, ultimately promoting tumorigenesis and metastasis in NPC. Significance: These findings demonstrate the clinical significance of the lncRNA FAM225A in nasopharyngeal carcinoma (NPC) and the regulatory mechanism involved in NPC development and progression, providing a novel prognostic indicator and promising therapeutic target.

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“…This is consistent with the pathway analysis and suggests the prominent roles of uncontrolled proliferation and increased migration ability in CSC feature initiation and maintenance. VIM [42], MMP2 [43], FGF2 [44], ITBG3 [45,46], ANXA6 [47] are metastasis-associated genes. The oncogenic roles of KCNMA1 has been revealed in breast, prostate, ovarian and colorectal cancers [48][49][50][51][52], and RRAD is associated with glucose uptake in a human ovarian cancer model [53] and implicated in non-small cell lung cancers [54].…”

Section: Discussionmentioning

confidence: 99%

Cancer Stem Cell Transcriptome Landscape Reveals Biomarkers Driving Breast Cancer Heterogeneity

Zhang

Chen

Zhang

et al. 2020

Preprint

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BackgroundBreast cancers are heterogeneous diseases with distinct clinical outcomes and cancer stem cell percentages. Exploring breast cancer stem cell landscape could help understand the heterogeneity of such cancers with profound clinical relevance.MethodsWe conducted transcriptional profiling of cancer stem cells and non-cancer stem cells isolated from 3 triple negative breast cancer cell lines, analyzed the cancer stem cell transcriptome landscape that drives breast cancer heterogeneity through differential expressed gene analysis, gene ontology and pathway enrichment as well as network construction, and performed experimental validations on the network hub gene.ResultsWe identified a cancer stem cell feature panel consisting of 122 and 381 over-represented and under-expressed genes capable of differentiating breast cancer subtypes. We also underpin the prominent roles of the PI3K-AKT pathway in empowering cancer cells with uncontrolled proliferative and migrative abilities that ultimately foster cancer stemness, and reveal the potential promotive roles of ATP6V1B1 on breast tumor stemness through functional in vitro studies. ConclusionsOur study contributes in identifying a cancer stem cell feature panel for breast tumors that drives breast cancer heterogeneity at the transcriptional level, which provides a reservoir for diagnostic marker and/or therapeutic target identification once experimentally validated as demonstrated by ATP6V1B1.

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Insufficient Radiofrequency Ablation Treated Hepatocellular Carcinoma Cells Promote Metastasis by Up-Regulation ITGB3

Cited by 31 publications

References 46 publications

PRELP has prognostic value and regulates cell proliferation and migration in hepatocellular carcinoma

PRELP has prognostic value and regulates cell proliferation and migration in hepatocellular carcinoma

Long Noncoding RNA FAM225A Promotes Nasopharyngeal Carcinoma Tumorigenesis and Metastasis by Acting as ceRNA to Sponge miR-590-3p/miR-1275 and Upregulate ITGB3

Cancer Stem Cell Transcriptome Landscape Reveals Biomarkers Driving Breast Cancer Heterogeneity

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