Insufficient iodine nutrition status and the risk of pre-eclampsia: a protocol for systematic review and meta-analysis

Businge, Charles Bitamazire; Madini, Namhla; Longo-Mbenza, Benjamin; Kengne, André Pascal

doi:10.1136/bmjopen-2018-025573

Cited by 4 publications

(8 citation statements)

References 31 publications

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Section: Methodsmentioning

confidence: 99%

“…Citations and abstracts were initially screened and duplicate citations excluded. Titles and abstracts were then screened following inclusion criteria described in the protocol, 17 after which the full texts of potentially eligible articles were obtained. These full texts were screened using a standardised and pretested form to include eligible studies.…”

Section: Methodsmentioning

confidence: 99%

“…This search was conducted using a predefined comprehensive and sensitive search strategy (table 1) combining relevant terms and synonyms, which are variably used to denote abnormally high BP in pregnancy and insufficient iodine intake or iodine deficiency as detailed in the published protocol for this review. 17 Study selection and data extraction Two authors (CBB and AU) independently screened the titles and abstracts of identified studies. Citations and abstracts were initially screened and duplicate citations excluded.…”

Section: Search Strategy and Selection Criteriamentioning

confidence: 99%

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Insufficient iodine nutrition status and the risk of pre-eclampsia: a systemic review and meta-analysis

et al. 2021

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BackgroundAlthough subclinical hypothyroidism in pregnancy is one of the established risk factors for pre-eclampsia, the link between iodine deficiency, the main cause of hypothyroidism, and pre-eclampsia remains uncertain. We conducted a systematic review to determine the iodine nutrition status of pregnant women with and without pre-eclampsia and the risk of pre-eclampsia due to iodine deficiency.MethodsMEDLINE, EMBASE, Google Scholar, Scopus and Africa-Wide Information were searched up to 30th June 2020. Random-effect model meta-analysis was used to pool mean difference in urinary iodine concentration (UIC) between pre-eclamptic and normotensive controls and pool ORs and incidence rates of pre-eclampsia among women with UIC <150 µg/L.ResultsFive eligible studies were included in the meta-analysis. There was a significant difference in the pooled mean UIC of 254 pre-eclamptic women and 210 normotensive controls enrolled in three eligible case–control studies (mean UIC 164.4 µg/L (95% CI 45.1 to 283.6, p<0.01, I2 >50)). The overall proportions of pre-eclampsia among women with UIC <150 µg/L and UIC >150 µg/L in two cross-sectional studies were 203/214 and 67/247, respectively, with a pooled OR of 0.01 (95% CI 0 to 4.23, p=0.14, I2 >50) for pre-eclampsia among women with UIC >150 µg/L. The overall incidence of pre-eclampsia among women with UIC <150 µg/L and UIC >150 µg/L in two cohort studies was 6/1411 and 3/2478, respectively, with a pooled risk ratio of 2.85 (95% CI 0.42 to 20.05, p=0.09, I2 <25).ConclusionAlthough pre-eclamptic women seem to have lower UIC than normotensive pregnant women, the available data are insufficient to provide a conclusive answer on association of iodine deficiency with pre-eclampsia risk.PROSPERO registration numberCRD42018099427.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Search Strategy and Selection Criteriamentioning

confidence: 99%

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Insufficient iodine nutrition status and the risk of pre-eclampsia: a systemic review and meta-analysis

et al. 2021

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“…They concluded that independent of study type, low iodine status had a major effect on mental development. It is also worth noting that Businge et al (2019) reported that although subclinical hypothyroidism during pregnancy is one of the key risk factors for pre-eclampsia, the connection between suboptimal iodine status and pre-eclampsia remains uncertain. Given the risks associated with pre-eclampsia, Businge et al (2019) proposed that a systematic review and metaanalysis on the subject should be undertaken.…”

Section: Iodine Status During Pregnancymentioning

confidence: 99%

MILK Symposium review: The importance of milk and dairy foods in the diets of infants, adolescents, pregnant women, adults, and the elderly

Givens

2020

Journal of Dairy Science

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The ongoing increase in life expectancy is not always accompanied by an increase in healthy life span. There is increasing evidence that dietary exposure in early life can substantially affect chronic disease risk in later life. Milk and dairy foods are important suppliers of a range of key nutrients, with some being particularly important at certain life stages. It is now recognized that milk protein can stimulate insulin-like growth factor-1 (IGF-1), essential for longitudinal bone growth and bone mass acquisition in young children, thus reducing the risk of stunting. Low milk consumption during adolescence, particularly by girls, may contribute to suboptimal intake of calcium, magnesium, iodine, and other important nutrients. Given the generally low vitamin D status of European populations, this may have already affected bone development, and any resulting reduced bone strength may become a big issue when the populations are much older. Suboptimal iodine status of many young women has already been reported together with several observational studies showing an association between suboptimal iodine status during pregnancy and reduced cognitive development in the offspring. There is now good evidence that consumption of milk and dairy foods does not lead to an increased risk of cardiovascular diseases and type 2 diabetes. Indeed, some negative associations are seen, notably between yogurt consumption and type 2 diabetes, which should be researched with urgency. Greater emphasis should be placed on reducing malnutrition in the elderly and on dietary approaches to reduce their loss of muscle mass, muscle functionality, and bone strength. Whey protein has been shown to be particularly effective for reducing muscle loss; this needs to be developed to provide simple dietary regimens for the elderly to follow.There is an ongoing, often too simplistic debate about the relative value of animal versus plant food sources for protein in particular. It is important that judgments on the replacement of dairy products with those from plants also include the evidence on relative functionality, which is not expressed in simple nutrient content (e.g., hypotensive and muscle synthesis stimulation effects). Only by considering such functionality will a true comparison be achieved.

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“…Nevertheless, there are some contradictory data, probably influenced by biological and methodological problems. Genetic and environmental factors such as inadequate iodine intake and vitamin D intake may cause variability regarding hypertension and preeclampsia outcomes in pregnant women with hypothyroidism [13][14][15] . The modifications on the definitions criterion of overt or subclinical hypothyroidism and gestational hypertension or preeclampsia may also influence the results [16][17][18][19] .…”

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confidence: 99%

Circulating RNA Transcriptome of Pregnant Women with TSH Just Above the Trimester-Specific Reference and its Correlation with the Hypertensive Phenotype

Hirata

Rocha

Silva

et al. 2020

Sci Rep

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During gestation, a woman's body undergoes physiological changes that alter thyroid function. pregnant women with hypothyroidism may exhibit gestational complications, including hypertension and preeclampsia. We investigated differentially expressed genes (DEGs) in circulating RNAs from pregnant women with tSH levels just above the normal range to determine the impact of a mild elevation of TSH in pregnancy. We selected three women with healthy thyroid pregnancy (HTP), three pregnant women with gestational hypothyroidism (GHT), and three nonpregnant women (NPG) to construct transcriptome libraries. We also compared our results with data from the GEO dataset and DisGeNET. We identified 1500 DEG in GHT and 1656 DEG in HTP. From GEO dataset, we recognized 453 DEGs in trimester-specific plasma RNA, 1263 DEGs in placental tissues from healthy women, 1031 DEGs from preeclamptic uteroplacental tissues and 1657 DEGs from placental tissues from severely preeclamptic women. In this scenario, 12.26% and 12.86% genes were shared between these datasets in GHT and HTP, respectively. We stablished 62 genes in GHT DEGs related to hypertensive phenotype hallmarks. In conclusion, even in women with a mild TSH increment, we were able to detect some DEGs that could be associated with a hypertensive phenotype.Circulating Ribonucleic Acid (RNA) represents a powerful strategy, less invasive and capable of real-time tracking diseases. The circulating protein codifying transcripts (mRNA, messenger RNA) may also provide clinically useful additional information when compared to the direct protein measurement 1 . This strategy is also sensible enough to detect fetal RNA circulating in the mother's blood 2 . The use of corticotropin-releasing hormone (CRH) mRNA detection in pregnancy was also reported to be capable of working as a molecular marker for preeclampsia 3 . Nevertheless, the transcriptome analysis is efficient enough to offer much more information than the use of a single RNA. The target RNA detection strategies, like RNA-Seq, can be performed in a simple blood sample and can give us the quantitative expression of the coding and noncoding RNA from the mother, the placenta or the fetus in a unique and noninvasive way 4 .During gestation, a woman's body undergoes physiological changes that alter thyroid function and thyroid hormone metabolism. Most of these changes are related to the increased demand for thyroid hormone by the mother and the fetus, the placental degradation of the hormone and the increase in the thyroxin-binding globulin (TBG) concentration. TBG increases due to an estrogenic stimulus during pregnancy, and for this reason, free thyroxine (FT 4 ) is highly influenced by the significant increase in the thyroxine (T 4 )-bound fraction.

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Insufficient iodine nutrition status and the risk of pre-eclampsia: a protocol for systematic review and meta-analysis

Cited by 4 publications

References 31 publications

Insufficient iodine nutrition status and the risk of pre-eclampsia: a systemic review and meta-analysis

Insufficient iodine nutrition status and the risk of pre-eclampsia: a systemic review and meta-analysis

MILK Symposium review: The importance of milk and dairy foods in the diets of infants, adolescents, pregnant women, adults, and the elderly

Circulating RNA Transcriptome of Pregnant Women with TSH Just Above the Trimester-Specific Reference and its Correlation with the Hypertensive Phenotype

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