2022
DOI: 10.21203/rs.3.rs-2171944/v1
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Insufficient HtrA2 causes meiotic defects by inducing cytoskeletal disorganization in aging germinal vesicle oocytes

Abstract: Background High-temperature requirement protease A2 (HtrA2/Omi) is a mitochondrial chaperone highly conserved from bacteria to humans. It plays an important role in mitochondrial homeostasis and apoptosis. In this study, we investigated the role of HtrA2 in mouse oocyte maturation. Methods The role of HtrA2 in mouse oocyte maturation was investigated by employing knockdown (KD) or overexpression (OE) of HtrA2 in young or old GV oocytes. We employed immunoblotting, immunostaining, fluorescent intensity quanti… Show more

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