Insufficiency of positive airway pressure treatment on increased mean platelet volume: a prospective controlled study in patients with obstructive sleep apnea syndrome

Ulusoy, Bülent; Oğuzhan, Tolga; Akyol, Mesut; Bozdemir, Kazım; Çiftçi, Bülent; Korkmaz, Mehmet

doi:10.1007/s11325-019-01918-z

Cited by 3 publications

(13 citation statements)

References 25 publications

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“…A total of thirty studies involving 6,560 OSAS subjects (mean age: 51 years, 72% male) and 1,724 healthy controls (mean age: 46 years, 61% male) were assessed [8,19,[61][62][63][64][65][66][67][68][69][70][71][72][74][75][76][77][78][79][80][81][82][83][84][85][86][87][88][89] (Table 1). Twenty-two studies were conducted in Turkey [8,19,61,62,[64][65][66][67][68][69][70]72,74,[76][77][78][82][83][84][85]…”

Section: Mpv 321 Characteristics Of the Included Studiesmentioning

confidence: 99%

“…Twenty-two studies were conducted in Turkey [8,19,61,62,[64][65][66][67][68][69][70]72,74,[76][77][78][82][83][84][85]87,88], two in Egypt [71,81], two in China [80,89], two in Greece [63,79], one in South Korea [75], and one in Romania [86]. Nineteen studies had a retrospective design [8,62,[65][66][67]71,72,[74][75][76][77][78]80,84,85,[87][88][89], whilst the remaining 11 were prospective [19,61,…”

Section: Mpv 321 Characteristics Of the Included Studiesmentioning

confidence: 99%

“…Eighteen studies [19,[63][64][65][66]69,70,[74][75][76][77][78]80,81,84,86,88,89] reported MPV values for mild disease, 19 for moderate disease [19,[63][64][65][66]69,70,[74][75][76][77][78]80,81,83,84,86,88,89], and 24 for severe disease [8,19,[61][62][63][64][65][66]69,70,[74][75][76][77][78]…”

Section: Mpv and Disease Severitymentioning

confidence: 99%

“…Five studies [8,62,82,83,86] also reported MPV values before and after CPAP treatment. Notably, a significant reduction was observed after treatment (SMD = −0.59, 95% CI: −1.02 to −0.16, p = 0.007; I 2 = 78.5%, p = 0.001, Supplemental Figure S10).…”

Section: Mpv and Cpap Treatmentmentioning

confidence: 99%

“…Fifteen studies with a total of 4899 OSAS patients (mean age: 50 years, 74% males) and 1132 healthy controls (mean age: 46 years, 60% males) from 15 studies were included in the evaluation of the PDW SMDs [8,63,66,[68][69][70][71][72][73][74]79,80,83,88,89] (Table 2). Nine studies were conducted in Turkey [8,66,[68][69][70]72,74,83,88], two in China [80,89], two in Greece [63,79], one in Egypt [71], and one in South Korea [73].…”

Section: Pdw 331 Characteristics Of the Included Studiesmentioning

confidence: 99%

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A Systematic Review and Meta-Analysis of Mean Platelet Volume and Platelet Distribution Width in Patients with Obstructive Sleep Apnoea Syndrome

Di Lorenzo,

Scala,

Mangoni

et al. 2024

Biomedicines

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Obstructive sleep apnoea syndrome (OSAS) is a highly prevalent yet underestimated disorder caused by the complete or partial obstruction of the upper airways. Although polysomnography is the gold standard for OSAS diagnosis, there is an active search for easily accessible biomarkers of disease presence and severity, particularly those reflecting morphological changes in specific blood cells. We investigated the associations between the presence and severity of OSAS, continuous positive airway pressure (CPAP) treatment, mean platelet volume (MPV), and platelet distribution width (PDW), routinely assessed as part of the complete blood count. From 262 retrieved records from PubMed, the Web of Science, Scopus, and Google Scholar, 31 manuscripts were selected for a final analysis, 30 investigating MPV and 15 investigating PDW. MPV was not statistically different between OSAS patients and healthy controls; however, it progressively increased with disease severity. By contrast, OSAS patients had significantly higher PDW values than controls (SMD = 0.40, 95% CI: 0.25 to 0.56; p ˂ 0.001), and the difference increased with disease severity. In a univariate meta-regression, there were significant associations between the MPV and publication year, the apnoea–hypopnea index, and diabetes mellitus, while no associations were observed with the PDW. No significant between-group differences were observed in the subgroup analyses. These data suggest that PDW, and to a lesser extent, MPV, are potential biomarkers of OSAS and require further research to ascertain their pathophysiological significance (PROSPERO, CRD42023459413).

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Section: Mpv 321 Characteristics Of the Included Studiesmentioning

confidence: 99%

Section: Mpv 321 Characteristics Of the Included Studiesmentioning

confidence: 99%

Section: Mpv and Disease Severitymentioning

confidence: 99%

Section: Mpv and Cpap Treatmentmentioning

confidence: 99%

Section: Pdw 331 Characteristics Of the Included Studiesmentioning

confidence: 99%

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A Systematic Review and Meta-Analysis of Mean Platelet Volume and Platelet Distribution Width in Patients with Obstructive Sleep Apnoea Syndrome

Di Lorenzo,

Scala,

Mangoni

et al. 2024

Biomedicines

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Association between mean platelet volume and obstructive sleep apnea-hypopnea syndrome: A systemic review and meta-analysis

Zeng,

He,

Chen

et al. 2024

PLoS ONE

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Background Despite polysomnography (PSG) being acknowledged being considered the gold standard for diagnosing obstructive sleep apnea-hypopnea syndrome (OSAHS), researchers have been seeking a biomarker that is less invasive, more practical in detection, and cost-effective for diagnosing and assessing the severity of the disease. To address this concern, the values of mean platelet volume (MPV) between patients with OSAHS and healthy controls were compared, and the relationship between MPV and multiple sleep monitoring parameters was analyzed in this study. Methods A comprehensive search was conducted across medical databases, including PubMed, Web of Science, EMBASE, CNKI, and Wanfang, up until August 2, 2023, to identify published articles related to OSAHS. This study reviewed the literature regarding the values of MPV in individuals with OSAHS and control groups, the Pearson/Spearman correlation coefficients between MPV and sleep monitoring parameters, and the odds ratios (OR) of MPV concerning the occurrence of cardiovascular diseases (CVDs) in patients with OSAHS. Meta-analyses were performed using standardized mean difference (SMD), Fisher’s z values correlation coefficients (ZCOR) and odds ratio (OR) as effect variables. A fixed-effect model was used if the heterogeneity was not significant (I2<50%); otherwise, a random-effect model was applied. We will also combine the treatment effect estimates of individual trials using fixed‐effect and random‐effects models. Statistical analysis was carried out by employing STATA 11.0 and R 4.1.3. Results In total, 31 articles were selected for the final analysis. The study involved 3604 patients and 1165 control individuals. The MPV in the OSAHS group was considerably elevated in comparison to the healthy controls (SMD = 0.37, 95%CI = 0.21–0.53, P < 0.001), particularly among individuals with severe OSAHS (SMD = 0.57, 95%CI = 0.23–0.90, P = 0.001). Subgroup analysis based on ethnicity, mean body mass index (BMI), and study design type also revealed a considerably higher MPV in the OSAHS category in comparison to the healthy controls. Furthermore, MPV showed correlations with various sleep monitoring parameters. The elevation of MPV may be one of the risk factors for CVDs in individuals with OSAHS (adjusted OR = 1.72, 95%CI = 1.08–2.73, P = 0.022). Conclusion MPV is a relatively simple, cost-effective, and practical indicator of the severity of OSAHS, with its values being linked to the risk of CVDs in individuals with OSAHS.

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Obstrüktif Uyku Apnede (OUA) Ortalama Trombosit Hacmi (OTH) ve OUA'da Sürekli Pozitif Hava Yolu Basıncı (CPAP) Tedavisinin OTH Üzerine Etkisi

ÇAKIROĞLU,

ANNAKKAYA,

ÖZMEN SÜNER

et al. 2024

Konuralp Tıp Dergisi

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Aims: In this study, our objective was to evaluate mean platelet volume (MPV), an indirect marker of platelet activation, in patients with obstructive sleep apnea (OSA), and assess the effect of OSA treatment with continuous positive airway pressure (CPAP) on MPV Methods: In this study, records of consecutive patients who underwent polysomnographic evaluation for OSA symptoms in the Sleep Disorders Laboratory during a one-year period were reviewed retrospectively. Patients who had both complete blood count and MPV measurements were included in the study. Results: A total of 158 patients, including 51 females (32.3%) and 107 males (67.7%), were included in the study. The mean age of the patients was 51±13 (min-18, max-82) years. OSA was detected in 74.1% (117/158) of the patients. It was determined that as the severity of OSA increased, hemoglobin and hematocrit values increased significantly. There was no significant difference in platelet count according to the presence and severity of OSA. The MPV was significantly lower in severe OSA cases compared to those without OSA and mild OSA cases. A negative correlation was observed between MPV and the apnea-hypopnea index, desaturation index, and the amount of oxygen saturation below 90% during sleep. There was no significant difference in median erythrocyte and thrombocyte counts, hematocrit percentage and hemoglobin values before and after treatment in OSA patients who used CPAP therapy. However, a significant decrease in MPV was observed after OSA treatment compared to pre-treatment. (p=0.021). Conclusions: The results of the study do not support an increase in MPV and hence platelet activation in severe OSA patients compared with those without OSA. However, the results suggest that one month of CPAP treatment reduces MPV and thus platelet activation in severe OSA patients. Further controlled, prospective studies including treatment outcomes are needed on this subject.

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Insufficiency of positive airway pressure treatment on increased mean platelet volume: a prospective controlled study in patients with obstructive sleep apnea syndrome

Cited by 3 publications

References 25 publications

A Systematic Review and Meta-Analysis of Mean Platelet Volume and Platelet Distribution Width in Patients with Obstructive Sleep Apnoea Syndrome

A Systematic Review and Meta-Analysis of Mean Platelet Volume and Platelet Distribution Width in Patients with Obstructive Sleep Apnoea Syndrome

Association between mean platelet volume and obstructive sleep apnea-hypopnea syndrome: A systemic review and meta-analysis

Obstrüktif Uyku Apnede (OUA) Ortalama Trombosit Hacmi (OTH) ve OUA'da Sürekli Pozitif Hava Yolu Basıncı (CPAP) Tedavisinin OTH Üzerine Etkisi

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