2012
DOI: 10.1016/j.ijpharm.2012.01.032
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Instrumented roll technology for the design space development of roller compaction process

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Cited by 27 publications
(17 citation statements)
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“…A similar model compared to the normal stress model from P2 only, was obtained, where hydraulic roll pressure, screw to roll speed ratio and the interaction term between them had significant effect on the average normal stress. These findings are consistent with those reported by Meyer et al (2005) and Nesarikar et al (2012b). Bindhumadhavan et al (2005) reported that the peak normal pressure decreased as the roll speed increased.…”
Section: Resultssupporting
confidence: 93%
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“…A similar model compared to the normal stress model from P2 only, was obtained, where hydraulic roll pressure, screw to roll speed ratio and the interaction term between them had significant effect on the average normal stress. These findings are consistent with those reported by Meyer et al (2005) and Nesarikar et al (2012b). Bindhumadhavan et al (2005) reported that the peak normal pressure decreased as the roll speed increased.…”
Section: Resultssupporting
confidence: 93%
“…This was attributed to heterogeneity of feeding pressure in the last flight of the feed screw and this has been previously reported in the literature (Simon and Guigon, 2003). Several researchers (Miguelez-Moran et al, 2009;Cunningham et al, 2010;Nesarikar et al, 2012b;Simon and Guigon, 2003Miguelez-Moran et al, 2009Cunningham et al, 2010Nesarikar et al, 2012b;Simon and Guigon, 2003) have shown that normal stress decreases and ribbon porosity increases near the ribbon edges due to side seal friction, resulting in variation of ribbon porosity across ribbon width. The variation of normal stress across the ribbon width leads to variation of the ribbon porosity.…”
Section: Resultsmentioning
confidence: 65%
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“…Compressibility constants between 4.5 and 5.9 were reported by Bi et al [16] in their experiments using formulations consisting of several materials, including Avicel PH-102. Nesarikar et al [22] also reported compressibility constants of between 4 and 6 in their formulations, which contained equal amounts of Avicel PH-102 and lactose as well as other components. Figure 5.4.…”
Section: Mass Correction Factormentioning
confidence: 97%