Instrumented measurements of laxity in patients who have a Gore-Tex anterior cruciate-ligament substitute.

Markolf, Keith L.; Pattee, Gary A.; Strum, G M; Gallick, G S; Sherman, Orrin H.; Nuys, V; Dorey, Fred

doi:10.2106/00004623-198971060-00013

Cited by 30 publications

(6 citation statements)

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“…Lateral subluxations were consequently rare. Our results agree with Markolf et al who concluded that anterior tibial displacement alone is not a good indicator of the quality of anterior cruciate reconstruction [11].…”

Section: Discussionsupporting

confidence: 93%

The MacIntosh lateral substitution reconstruction for anterior cruciate deficiency

Osterman

Kivimaki²,

Österman

1993

International Orthopaedics

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Twenty-five patients who had anterior cruciate deficient knees treated by the MacIntosh reconstruction operation were reviewed after 5 years, with particular reference to any changes occurring over time. Subjectively, the knees were improved and the results were even better after 5 years than after one year. This was considered to be due to a decrease in the restriction of flexion, and to the psychological and functional adaptation to the injured knee. In the knees operated on, the anterolateral instability increased significantly during the follow up from one year (mean 1.9 mm) to 5 years (3.0 mm), but the numerical value was still as good as in the intact knees (3.5 mm).

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Section: Discussionsupporting

confidence: 93%

The MacIntosh lateral substitution reconstruction for anterior cruciate deficiency

Osterman

Kivimaki²,

Österman

1993

International Orthopaedics

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“…Our results concerning improved stability for Goretex-reconstructed knees are in agreement with, or even better than, other reports (Indelicato et al 1989, Markolf et al 1989. The lower functional and activity scores among Goretex patients were due to pain and effusion.…”

Section: Discussionsupporting

confidence: 92%

Cruciate ligament prosthesis vs. augmentation: A randomized, prospective 5-year follow-up of 41 cases

Dahlstedt

Dalén

Jönsson

et al. 1993

Acta Orthopaedica Scandinavica

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“…Their biocompatibility, biodegradability and extraordinary material properties make them exceptional candidates for biomedical applications. The success of tissue engineering relies on achieving synchronized rates of scaffold degradation and new tissue formation (Langer and Vacanti, 1993), where the degradation of biomaterials should match the functional needs and ensure optimum mechanical and physiological integration of the scaffold (Bonnarens and Drez, 1987;Dunn et al, 1993;Dürselen et al, 2001;Kumar and Maffulli, 1999;Lu et al, 2000;Markolf et al, 1989;Richmond et al, 1992;Vepari and Kaplan, 2007). The rate and extent of degradation of natural polymers is variable, depending on structural and morphological features of the polymers (e.g., crystallinity, roughness), processing conditions and location of implantation (Arai et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Predicting rates of in vivo degradation of recombinant spider silk proteins

Dinjaski

Ebrahimi

Qin

et al. 2017

J Tissue Eng Regen Med

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Developing fundamental tools and insight into biomaterial designs for predictive functional outcomes remains critical for the field. Silk is a promising candidate as a biomaterial for tissue engineering scaffolds, particularly where high mechanical loads or slow rates of degradation are desirable. Although bioinspired synthetic spider silks are feasible biomaterials for this purpose, insight into how well the degradation rate can be programmed by fine tuning the sequence remains to be determined. Here we integrated experimental approaches and computational modelling to investigate the degradation of two bioengineered spider silk block copolymers, H(AB) 2 and H(AB) 12 , which were designed based on the consensus domains of Nephila clavipes dragline silk. The effect of protein chain length and secondary structure on degradation was analysed in vivo. The degradation rate of H(AB) 12 , the silk with longer chain length/higher molecular weight, and higher crystallinity, was slower when compared to H(AB) 2 . Using full atomistic modelling, it was determined that the faster degradation of H(AB) 2 was due to the lower folded molecular structure of the silk and the greater accessibility to solvent. Comparison of the specific surface areas of proteins via modelling showed that higher exposure of random coil and lower exposure of ordered domains in H(AB) 2 led to the more reactive silk with a higher degradation rate when compared with H(AB) 12 , as validated by the experimental results. The study, based on two simple silk designs demonstrated that the control of sequence can lead to programmable degradation rates for these biomaterials, providing a suitable model system with which to study variables in protein polymer design to predict degradation rates in vivo. This approach should reduce the use of animal screening, while also accelerating translation of such biomaterials for repair and regenerative systems.

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Instrumented measurements of laxity in patients who have a Gore-Tex anterior cruciate-ligament substitute.

Cited by 30 publications

References 0 publications

The MacIntosh lateral substitution reconstruction for anterior cruciate deficiency

The MacIntosh lateral substitution reconstruction for anterior cruciate deficiency

Cruciate ligament prosthesis vs. augmentation: A randomized, prospective 5-year follow-up of 41 cases

Predicting rates of in vivo degradation of recombinant spider silk proteins

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