Instrumentation for diagnostics and control of laser-accelerated proton (ion) beams

Bolton, Paul R.; Borghesi, M.; Brenner, C. M.; Carroll, D. C.; Martinis, C. De; Fiorini, F.; Flacco, Alessandro; Floquet, V.; Fuchs, Julien; Gallegos, P.; Giove, D.; Green, J S; Green, S; Jones, Bleddyn; Kirby, D.; McKenna, P.; Neely, D.; Nuesslin, F.; Prasad, R.; Reinhardt, S.; Roth, Markus; Schramm, U.; Scott, Graeme; Ter‐Avetisyan, S.; Tolley, M.; Turchetti, G.; Wilkens, Jan J.

doi:10.1016/j.ejmp.2013.09.002

Cited by 92 publications

(82 citation statements)

References 70 publications

(89 reference statements)

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“…For liquid samples, the dose rate was decreased to 4 Gy/min by adjusting the parameters of the internal ion source. In comparison with high-peak-power laser-driven proton sources (Bin et al 2012;Bolton et al 2014;Kraft et al 2010;Malka et al 2008;Yogo et al 2011;Zlobinskaya et al 2014), the dose in this study is delivered in enormous number of bunches, thus serving as a low-dose-rate reference for investigations of dose rate effects in radiation biophysics.…”

Section: Proton Irradiationmentioning

confidence: 99%

Proton-induced direct and indirect damage of plasmid DNA

Vyšín

Brabcová

Štěpán

et al. 2015

Radiat Environ Biophys

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Clustered DNA damage induced by 10, 20 and 30 MeV protons in pBR322 plasmid DNA was investigated. Besides determination of strand breaks, additional lesions were detected using base excision repair enzymes. The plasmid was irradiated in dry form, where indirect radiation effects were almost fully suppressed, and in water solution containing only minimal residual radical scavenger. Simultaneous irradiation of the plasmid DNA in the dry form and in the solution demonstrated the contribution of the indirect effect as prevalent. The damage composition slightly differed when comparing the results for liquid and dry samples. The obtained data were also subjected to analysis concerning different methodological approaches, particularly the influence of irradiation geometry, models used for calculation of strand break yields and interpretation of the strand breaks detected with the enzymes. It was shown that these parameters strongly affect the results.

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Section: Proton Irradiationmentioning

confidence: 99%

Proton-induced direct and indirect damage of plasmid DNA

Vyšín

Brabcová

Štěpán

et al. 2015

Radiat Environ Biophys

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“…3,4 Given these properties, there are two major challenges that need to be addressed: a controlled beam production and an efficient beam guidance. Other challenges like sufficient proton energy (about 250 MeV) and suitable beam diagnostics 5 for patient treatment are listed by Linz 6 but are of minor relevance for this study which focuses more on providing clinical feasibility and a future directive for laser-acceleration and gantry development.…”

Section: Introductionmentioning

confidence: 99%

A treatment planning study to assess the feasibility of laser‐driven proton therapy using a compact gantry design

et al. 2015

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Under the analyzed terms, it is feasible to achieve clinically relevant dose distributions with laser-driven proton beams. However, to keep the delivery times of the proton plans comparable to conventional proton plans for typical target volumes, a device is required which can modulate the bunch intensity from shot to shot. From the laser acceleration point of view, the proton number per bunch must be kept under control as well as the reproducibility of the bunches.

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“…Ref. [11] for a comprehensive overview of detection methods). However, in presence of a multi-species ion beam dominated by protons, as typically obtained from laser driven sources, these diagnostics mainly provide information about the protons due to their lowest stopping power amongst all ion species.…”

Section: Introductionmentioning

confidence: 99%