Instrumental Evaluation of the Depigmenting Efficacy of an Oral Supplementation Containing Peptides and Chrysanthemum Extract for the Treatment of Melasma

Abstract

Abstract:The aim of this study was to assess the efficacy of an oral supplement (CP) containing collagen peptide, soy peptide, and chrysanthemum extract in Chinese female adult volunteers with melasma. The approval of the Institutional Ethics Committee of the third affiliated hospital, Sun-Yat Sen University, was obtained before the study. A signed consent was obtained from each volunteer prior to study to enable the volunteer to appreciate the aim of the study and the consequences of her consent. Sixty-two female volunteers aged 30-60 years were included in the study, and were randomized into a treatment group or a placebo group. The skin tone of the pigmented spots was evaluated using Chromameter, and pigment density was evaluated using Mexameter before and after the treatment. Significant changes in skin tone parameters of L value and ITA • (individual typology angle) were detected in the lesion area after the treatment (P < 0.01). When compared with placebo group, the treatment group achieved significant improvement in the brightness of the pigmented spots at the 45 and 60-day time points. A significant decrease in the level of melanin was observed in the treatment group when compared with the placebo group (p < 0.01). All data demonstrated through non-invasive in vivo instrumental measurement that daily oral intake of CP had clinical efficacy of reducing melasma severity.

Formulation of Liquid Soap Contains Cow's Milk from Middle Small Enterprise in Cimahi

“…9 Uji efektivitas dengan alat kromameter bertujuan untuk mengamati daya pembersihan dari sediaan sabun susu sapi. 10 Pengujian ini dilakukan terhadap 3 orang responden. Sebelum responden menggunakan sediaan sabun cair, tiap responden menggunakan alas bedak atau lipstik terlebih dahulu pada kulit lengan bagian bawah.…”

Collagen Hydrolysates for Skin Protection: Oral Administration and Topical Formulation

“…Continuous exposition to UV-B results in an aged skin with wrinkle formation [113]. The benefits of a novel oral supplement (CP) prepared with fish skin HC combined with soy peptides and aqueous extract of Flos Chrysanthemi Alba were investigated in a clinical study to evaluate the safety and efficacy of CP to treat melasma [114]. Sixty-two healthy female volunteers who were diagnosed with melasma by a dermatologist were included in the study.…”

Collagen and soy peptides attenuate contractile loss from UVA damage and enhance the antioxidant capacity of dermal fibroblasts

“…Soy peptides and collagen peptides have been used as important active components in medicinal and food industries because of their excellent bioactivity, good biocompatibility, and penetrability. Previously, enzymatic hydrolysates of soy peptide (SP) and collagen peptide (CP) have been administrated as antioxidants to protect skin from UV 16‐29 . The combination of SP and CP has been shown to improve skin function 19,27 .…”

“…19,27 Furthermore, two articles we published disclosed that oral administration of the combination of SP and CP either in mice or female adult volunteers enhanced the antimelanogenic and antioxidative activities for skin. 28,29 Collagen is made up of glycine (33%), proline (12%-13%), hydroxyproline (9%-10%), and alanine (12%-13%). Recent studies have shown that oral collagen intake resulted in an increase of skin elasticity and skin moisture.…”

“…Previously, enzymatic hydrolysates of soy peptide (SP) and collagen peptide (CP) have been administrated as antioxidants to protect skin from UV. [16][17][18][19][20][21][22][23][24][25][26][27][28][29] The combination of SP and CP has been shown to improve skin function. 19,27 Furthermore, two articles we published disclosed that oral administration of the combination of SP and CP either in mice or female adult volunteers enhanced the antimelanogenic and antioxidative activities for skin.…”