Instrumental and transcriptome analysis reveals the chemotherapeutic effects of doxorubicin-loaded black phosphate nanosheets on abiraterone-resistant prostate cancer

Xu, Haoyang; Liu, Jiaqi; Li, Xiangkai; Li, Jiawei; Lin, Xiao; Li, Zhuowei; Dou, Tong; Li, Rong; Lai, Keng Po

doi:10.1016/j.bioorg.2023.106583

Cited by 1 publication

(1 citation statement)

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“…According to the findings, black phosphorus nanosheets inhibited the migration and proliferation of cancer cells that are resistant to abiraterone. Gene ontology, enrichment analysis, and ingenious pathway analysis of the differentially expressed genes revealed that black phosphorus nanosheet treatment regulated the growth and metastasis of cancer cells as well as oncogenic signaling pathways [ 136 ]. Nanosheets have been found to be advantageous in the treatment of abiraterone-resistant cancer, which shows their potential in the treatment of prostate cancer.…”

Section: Prostate Cancer Treatment By Novel Drug Delivery Systemmentioning

confidence: 99%

Emerging Trends of Nanomedicines in the Management of Prostate Cancer: Perspectives and Potential Applications

Deshmukh,

Singh,

Harwansh

et al. 2024

Pharmaceutics

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Prostate cancer is one of the most life-threatening disorders that occur in males. It has now become the third most common disease all over the world, and emerging cases and spiking mortality rates are becoming more challenging day by day. Several approaches have been used to treat prostate cancer, including surgery, radiation therapy, chemotherapy, etc. These are painful and invasive ways of treatment. Primarily, chemotherapy has been associated with numerous drawbacks restricting its further application. The majority of prostate cancers have the potential to become castration-resistant. Prostate cancer cells exhibit resistance to chemotherapy, resistance to radiation, ADT (androgen-deprivation therapy) resistance, and immune stiffness as a result of activating tumor-promoting signaling pathways and developing resistance to various treatment modalities. Nanomedicines such as liposomes, nanoparticles, branched dendrimers, carbon nanotubes, and quantum dots are promising disease management techniques in this context. Nanomedicines can target the drugs to the target site and enhance the drug’s action for a prolonged period. They may also increase the solubility and bioavailability of poorly soluble drugs. This review summarizes the current data on nanomedicines for the prevention and treatment of prostate cancer. Thus, nanomedicine is pioneering in disease management.

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Section: Prostate Cancer Treatment By Novel Drug Delivery Systemmentioning

confidence: 99%