Instrumental Activities of Daily Living as a Screening Tool for Cognitive Impairment and Dementia in Elderly Community Dwellers

Barberger‐Gateau, Pascale; Commenges, Daniel; Gagnon, Marc‐André; Letenneur, Luc; Sauvel, C.; Dartigues, Jean‐François

doi:10.1111/j.1532-5415.1992.tb01802.x

Cited by 373 publications

(266 citation statements)

References 32 publications

Supporting

Mentioning

249

Contrasting

Unclassified

Order By: Relevance

“…Functional ability was evaluated using Barthel's basic activities of daily living (ADL) index and Lawton and Brody's instrumental ADL (iADL) index (Mahoney and Barthel 1965;Barberger-Gateau et al 1992). Physical activity level was captured using the Frenchay activity scale (Wade et al 1985).…”

Section: Clinical Assessmentsmentioning

confidence: 99%

Sex-specific differences in risk factors for sarcopenia amongst community-dwelling older adults

Tay

Ding

Leung

et al. 2015

AGE

134

View full text Add to dashboard Cite

With considerable variation including potential sex-specific differential rate of skeletal muscle loss, identifying modifiable factors for sarcopenia will be pivotal to guide targeted interventions. This study seeks to identify clinical and biological correlates of sarcopenia in community-dwelling older adults, with emphasis on the role of anabolic and catabolic stimuli, and special reference to gender specificity. In this crosssectional study involving 200 community-dwelling and functionally independent older adults aged ≥50 years, sarcopenia was defined using the Asian Working Group for Sarcopenia criteria. Comorbidities, cognitive and functional performance, physical activity and nutritional status were routinely assessed. Biochemical parameters included haematological indices, lipid panel, vitamin D level, anabolic hormones [insulin-like growth factor-1 (IGF-1), free testosterone (males only)] and catabolic markers [inflammatory markers (interleukin-6, Creactive protein) and myostatin]. Multiple logistic regression was performed to identify independent predictors for sarcopenia. Age was associated with sarcopenia in both genders. Malnutrition conferred significantly higher odds for sarcopenia in women (OR=5.71, 95 % CI 1.13-28.84.44, p=0.035) while higher but acceptable range serum triglyceride was protective in men (OR=0.05, 95 % CI 0.00-0.52, p=0.012). Higher serum myostatin independently associated with higher odds for sarcopenia in men (OR=1.11, 95 % CI 1.00-1.24, p=0.041). Serum IGF-1 was significantly lower amongst female sarcopenic subjects, with demonstrable trend for protective effect against sarcopenia in multiple regression models, such that each 1 ng/ml increase in IGF-1 was associated with 1 % decline in odds of sarcopenia in women (p=0.095). Our findings support differential pathophysiological mechanisms for sarcopenia that, if corroborated, may have clinical utility in guiding sex-specific targeted interventions for community-dwelling older adults.

show abstract

Section: Clinical Assessmentsmentioning

confidence: 99%

Sex-specific differences in risk factors for sarcopenia amongst community-dwelling older adults

Tay

Ding

Leung

et al. 2015

AGE

134

View full text Add to dashboard Cite

show abstract

“…We included 24 elderly individuals (mean age 68.8 ± 4.0 years, range 62-80 years, 17 females, 8-11 years of education). All participants were screened with the Mini Mental State Examination (Folstein et al, 1975), the Lawton's Instrumental Activities of Daily Living (Barberger-Gateau et al, 1992), and the Hospital Anxiety and Depression Scale (Zigmond and Snaith, 1983). Cognitive evaluation was performed as follows: attention (Code, Trail Making Test A), WM (verbal: Digit Span Forward (Wechsler, 1955), visuo-spatial: Corsi Block Tapping (Milner, 1971)), episodic memory (verbal: Buschke Double Memory 48 items (Buschke et al, 1997), visual: Shapes (Baddley et al, 1994)), executive functions (Trail Making Test B (Reitan, 1958)), language (Boston Naming (Kaplan et al, 1983)), visual gnosis (Ghent Overlapping Figures).…”

Section: Experimental Procedures Participantsmentioning

confidence: 99%

Acute caffeine administration impact on working memory-related brain activation and functional connectivity in the elderly: A BOLD and perfusion MRI study

et al. 2013

View full text Add to dashboard Cite

Abstract-In young individuals, caffeine-mediated blockade of adenosine receptors and vasoconstriction has direct repercussions on task-related activations, changes in functional connectivity, as well as global vascular effects. To date, no study has explored the effect of caffeine on brain activation patterns during highly demanding cognitive tasks in the elderly. This prospective, placebo-controlled crossover design comprises 24 healthy elderly individuals (mean age 68.8 ± 4.0 years, 17 females) performing a 2-back working memory (WM) task in functional magnetic resonance imaging (fMRI). Analyses include complimentary assessment of task-related activations (general linear model, GLM), functional connectivity (tensorial independent component analysis, TICA), and baseline perfusion (arterial spin labeling). Despite a reduction in whole-brain global perfusion (À22.7%), caffeine-enhanced task-related GLM activation in a local and distributed network is most pronounced in the bilateral striatum and to a lesser degree in the right middle and inferior frontal gyrus, bilateral insula, left superior and inferior parietal lobule as well as in the cerebellum bilaterally. TICA was significantly enhanced (+8.2%) in caffeine versus placebo in a distributed and task-relevant network including the pre-frontal cortex, the supplementary motor area, the ventral premotor cortex and the parietal cortex as well as the occipital cortex (visual stimuli) and basal ganglia. The inverse comparison of placebo versus caffeine had no significant difference. Activation strength of the task-relevant-network component correlated with response accuracy for caffeine yet not for placebo, indicating a selective cognitive effect of caffeine. The present findings suggest that acute caffeine intake enhances WM-related brain activation as well as functional connectivity of blood oxygen level-dependent fMRI in elderly individuals. Ó

show abstract

“…The education level was defined according to the Swiss scholar system, where level 1 ϭ less than 9 years (primary school), level 2 ϭ between 9 and 12 years (high school), and level 3 ϭ more than 12 years (university). All subjects were screened with the Mini-Mental State Examination, 46 the Lawton Instrumental Activities of Daily Living, 47 and the Hospital Anxiety and Depression Scale. 48 In addition, 65 These patients were reviewed independently by 2 highly experienced clinicians, blinded to each other's findings, and were included in the respective MCI groups only if both clinicians con-curred on the diagnosis.…”

Section: Participantsmentioning

confidence: 99%

Individual Classification of Mild Cognitive Impairment Subtypes by Support Vector Machine Analysis of White Matter DTI

Haller¹,

Missonnier²,

Herrmann

et al. 2012

AJNR Am J Neuroradiol

View full text Add to dashboard Cite

show abstract

Instrumental Activities of Daily Living as a Screening Tool for Cognitive Impairment and Dementia in Elderly Community Dwellers

Abstract: The four IADL score could be incorporated into the screening procedure for dementia in elderly community dwellers.

Cited by 373 publications

References 32 publications

Sex-specific differences in risk factors for sarcopenia amongst community-dwelling older adults

Sex-specific differences in risk factors for sarcopenia amongst community-dwelling older adults

Acute caffeine administration impact on working memory-related brain activation and functional connectivity in the elderly: A BOLD and perfusion MRI study

Individual Classification of Mild Cognitive Impairment Subtypes by Support Vector Machine Analysis of White Matter DTI

Contact Info

Product

Resources

About