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Thiede, Hans-Michael; Walper, Andreas

doi:10.1177/089198879400700114

Cited by 64 publications

(5 citation statements)

References 7 publications

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“…MAO-A inhibitor drugs have been accepted in the treatment of depressive states . It has been suggested that the antidepressive-like activity of natural flavonoids such as quercetin was due, at least partially, to their MAO-inhibitory properties, , though only a few studies compare their neurochemical effects obtained in vitro with the behavioral profile displayed in animal models.…”

Section: Resultsmentioning

confidence: 99%

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Quercetin as the Active Principle ofHypericumhircinumExerts a Selective Inhibitory Activity against MAO-A: Extraction, Biological Analysis, and Computational Study

et al. 2006

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The methanol extract from Hypericum hircinum leaves exhibited in vitro inhibition of monoamine oxidases (MAO). Bioassay-guided fractionation led to the isolation of quercetin and five compounds identified for the first time from H. hircinum. Quercetin was the only compound with a selective inhibitory activity against MAO-A, with an IC50 value of 0.010 microM. To explain MAO selective inhibition at the molecular level, a computational study was carried out by conformational search and docking techniques using recently determined crystallographic models of both enzymatic isoforms. An in vivo study in mice was carried out using the forced swimming test in order to elucidate the behavioral effects of quercetin.

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Section: Resultsmentioning

confidence: 99%

“…Various studies have shown that quercetin has wide-ranging pharmacological actions − and acts as a COMPT/MAO inhibitor …”

mentioning

confidence: 99%

Quercetin as the Active Principle ofHypericumhircinumExerts a Selective Inhibitory Activity against MAO-A: Extraction, Biological Analysis, and Computational Study

et al. 2006

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“…The mechanism underlying the antidepressant activity of St. John's wort is still not fully understood, but several compounds belonging to different structural classes and having different mechanisms of action seem to be responsible for the observed activity. − Thus, on the basis of recent results, it seems likely that phloroglucinols, naphtodianthrones, and flavonoids contribute to the antidepressant activity of St. John's wort. The phloroglucinol hyperforin has been shown to inhibit the reuptake of dopamine, serotonin, noradrenaline, γ-aminobutyric acid, and l -glutamate. − While initial studies showed that hypericin inhibits the monoamine oxidases (MAO) type A and B, this result has been a matter of debate, and several studies have shown that the MAO-A and MAO-B inhibitory effects are attributable to flavonoids. − Furthermore, flavonoids were recently shown to be opioid receptor ligands . The activity of St. John's wort flavonoids, as well as of solubilized hypericin and pseudohypericin, has been demonstrated in the forced swimming test. , Clinical studies support the antidepressant activity of hyperforin. , …”

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confidence: 99%

Combining PARAFAC Analysis of HPLC-PDA Profiles and Structural Characterization Using HPLC-PDA-SPE-NMR-MS Experiments: Commercial Preparations of St. John's Wort

et al. 2008

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Herbal preparations represent very complex mixtures, potentially containing multiple pharmacologically active entities. Methods for global characterization of the composition of such mixtures are therefore of pertinent interest. In this work, chemometric analysis of high-performance liquid chromatography with photodiode-array detection (HPLC-PDA) data from extracts of commercial preparations of Hypericum perforatum (St. John's wort) that originate from several continents is described. The spectral HPLC profiles were aligned in the elution mode using correlation optimized warping in order to remove peak misalignment caused by retention time shifts due to matrix effects. Furthermore, the warping was assisted by HPLC-PDA-SPE-NMR-MS (SPE = solid-phase extraction) experiments that yielded 1H NMR and 13C NMR data (from 1H-detected heteronuclear correlations), as well as ESI-MS and HRMS data, which enabled the identification of all major mixture constituents. The preprocessed HPLC-PDA data were subjected to parallel factor analysis (PARAFAC), a chemometric method that is a generalization of principal component analysis (PCA) to multi-way data arrays. PCA of the peak areas obtained from the PARAFAC analysis was used to facilitate sample comparison and allowed straightforward interpretation of constituents responsible for the differences in composition between individual preparations. In addition, loadings from the PARAFAC analysis provided pure elution profiles and pure UV spectra even for coeluting peaks, thus enabling the identification of chromatographically unresolved components. In conclusion, PARAFAC analysis of the readily accessible HPLC-PDA data provides the means for unsupervised and unbiased assessment of the composition of herbal preparations, of interest for assessment of their pharmacological activity and clinical efficacy.

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“…Biomedical research, focusing on singular mechanisms of actions, showed antidepressant effects in SJW due to the hypericin constituent (Bladt & Wagner, 1994; Thiede & Walper, 1994). This finding resulted in multiple clinical trials and the standardization of SJW products to hypericin with the identification of SJW as the herbal antidepressant.…”

Section: Current Challenge For Herbal Medicinementioning

confidence: 99%

Traditional knowledge of Western herbal medicine and complex systems science

Niemeyer

Bell

Koithan

2013

Journal of Herbal Medicine

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Traditional knowledge of Western herbal medicine (WHM) supports experiential approaches to healing that have evolved over time. This is evident in the use of polyherb formulations comprised of crude plant parts, individually tailored to treat the cause of dysfunction and imbalance by addressing the whole person holistically. The challenge for WHM is to integrate science with traditional knowledge that is a foundation of the practice of WHM. The purpose of this paper is to provide a plausible theoretical hypothesis by applying complex systems science to WHM, illustrating how medicinal plants are complex, adaptive, environmentally interactive systems exhibiting synergy and nonlinear healing causality. This paper explores the conceptual congruence between medicinal plants and humans as complex systems coherently coupled through recurrent interaction. Complex systems science provides the theoretical tenets that explain traditional knowledge of medicinal plants while supporting clinical practice and expanding research and documentation of WHM.

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Instructions for Authors

Cited by 64 publications

References 7 publications

Quercetin as the Active Principle ofHypericumhircinumExerts a Selective Inhibitory Activity against MAO-A: Extraction, Biological Analysis, and Computational Study

Quercetin as the Active Principle ofHypericumhircinumExerts a Selective Inhibitory Activity against MAO-A: Extraction, Biological Analysis, and Computational Study

Combining PARAFAC Analysis of HPLC-PDA Profiles and Structural Characterization Using HPLC-PDA-SPE-NMR-MS Experiments: Commercial Preparations of St. John's Wort

Traditional knowledge of Western herbal medicine and complex systems science

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