Instability in the faecal flora of a patient suffering from food-related irritable bowel syndrome

Bradley, H K; Wyatt, G. M.; Bayliss, Catherine E.; Hunter, JO

doi:10.1099/00222615-23-1-29

Cited by 59 publications

(29 citation statements)

References 10 publications

(5 reference statements)

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“…Alternately, could this low-grade inflammation represent either an abnormal reaction to the normal flora or a contained response to qualitative or quantitative changes in the intrinsic flora? Whether IBS is accompanied by quantitative or qualitative changes in the bacterial flora of the small or large intestine remains a contentious issue; while some have described bacterial overgrowth in the small intestine [39,40] and qualitative alterations in the fecal flora [41,43] and increased bacterial fermentation [44] , in IBS, others have failed to replicate these findings [45] . The description of efficacy for certain probiotics, and bifidobacterium, in particular, in IBS [37] could also support a role of gut flora-mucosal interaction in IBS [46] .…”

Section: Infection Inflammation Immunity and Ibsmentioning

confidence: 88%

Changing face of irritable bowel syndrome

Quigley¹

2006

WJG

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Recent years have witnessed tremendous progress in our understanding of irritable bowel syndrome (IBS). It is evident that this is a truly global disease associated with significant symptoms and impairments in personal and social functioning for afflicted individuals. Advances in our understanding of gut flora-mucosal interactions, the enteric nervous system and the brain-gut axis have led to substantial progress in the pathogenesis of symptoms in IBS and have provided some hints towards the basic etiology of this disorder, in some subpopulations, at the very least. We look forward to a time when therapy will be addressed to pathophysiology and perhaps, even to primary etiology. In the meantime, a model based on a primary role for intestinal inflammation serves to integrate the various strands, which contribute to the presentation of IBS

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Section: Infection Inflammation Immunity and Ibsmentioning

confidence: 88%

Changing face of irritable bowel syndrome

Quigley¹

2006

WJG

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“…There is a marked interindividual difference in bacterial species (40) and indeed the fecal flora in IBS subjects appears to be unstable and constantly changing (10). Other products of bacterial metabolism may be directly toxic to the gut mucosa.…”

Section: Discussionmentioning

confidence: 99%

“…(9). Long-term follow-up of the flora of IBS patients suggests that the flora is unstable, with alteration in the rank order of species (10) in contrast to healthy individuals (11a). Many IBS patients report exacerbation of symptoms by specific foods, and restrictive diets avoiding such foods may lead to improvement of their symptoms (12)(13)(14).…”

mentioning

confidence: 98%

Do Interventions Which Reduce Colonic Bacterial Fermentation Improve Symptoms of Irritable Bowel Syndrome?

2005

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Abnormal fermentation may be an important factor in irritable bowel syndrome (IBS). Gastroenteritis or antibiotic therapy may damage the colonic microflora, leading to increased fermentation and the accumulation of gas. Gas excretion may be measured by whole-body calorimetry but there has only been one such study on IBS to date. We aimed to assess the relationship between IBS symptoms and fermentation rates in IBS. A purpose-built, 1.4-m3, whole-body calorimeter was used to assess excretion of H2 and CH4 in IBS subjects while consuming a standard diet and, again, after open randomization on either the standard diet together with the antibiotic metronidazole or a fiber-free diet to reduce fermentation. Metronidazole significantly reduced the 24-hr excretion of hydrogen (median value compared to the control group, 397 vs 230 ml/24 hr) and total gas (H2 + CH4; 671 vs 422 ml/min) and the maximum rate of gas excretion (1.6 vs 0.8 ml/min), as did a no-fiber polymeric diet (hydrogen, 418 vs 176 ml/min; total gas, 564 vs 205 ml/min; maximum rate of gas excretion, 1.35 vs 0.45 ml/min), with a significant improvement in abdominal symptoms. IBS may be associated with rapid excretion of gaseous products of fermentation, whose reduction may improve symptoms.

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“…These include psychosocial factors, altered bowel motility, heightened function of the intestine, imbalance in neurotransmitters, and infection (Horwitz and Fisher, 2001). It has been suggested that symptoms of IBS could be (at least partly) attributable to disturbed intestinal microbiota (Balsari et al, 1982;Bradley et al, 1987;Borody et al, 1989;King et al, 1998). Increased colonic gas production, common in IBS subjects, has been explained by an abnormal colonic fermentation (King et al, 1998;Nobaek et al, 2000) and by excessive swallowed air (Haderstorfer et al, 1989).…”

Section: Irritable Bowel Syndrome (Ibs)mentioning

confidence: 99%

Gut bacteria and health foods—the European perspective

Saarela

Lähteenmäki

Crittenden

et al. 2002

International Journal of Food Microbiology

258

139

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Probiotics, prebiotics, and synbiotics aimed at improving intestinal health currently represent the largest segment of the functional foods market in Europe, Japan and Australia. Evidence continues to emerge demonstrating that these ingredients have the potential to improve human health in specific intestinal disorders. The European Commission, through its 5th Framework Programme, is presently focusing on a substantial effort in the science of the intestinal microbiota, its interaction with its host and methods to manipulate its composition and activity for the improvement of human health and well being. Eight multicentre and multidisciplinary research projects now cover a range of topics required for the development of efficacious probiotic foods, from understanding probiotic mechanisms at a molecular level; developing technologies to ensure delivery of stable products; and demonstrating safety and efficacy of specific probiotics in defined treatment targets. This concerted research effort promises to provide us with an enhanced understanding of the human intestinal microbiota's role in health and disease, and new approaches and products to tackle a variety of intestinal problems. D

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Instability in the faecal flora of a patient suffering from food-related irritable bowel syndrome

Cited by 59 publications

References 10 publications

Changing face of irritable bowel syndrome

Changing face of irritable bowel syndrome

Do Interventions Which Reduce Colonic Bacterial Fermentation Improve Symptoms of Irritable Bowel Syndrome?

Gut bacteria and health foods—the European perspective

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