Inspiring process innovation <i>via</i> an improved green manufacturing metric: iGAL

Roschangar, Frank; Zhou, YanYan; Constable, David J. C.; Colberg, Juan; Dickson, David P.; Dunn, Peter J.; Eastgate, Martin D.; Gallou, Fabrice; Hayler, John; Koenig, Stefan G.; Kopach, Michael E.; Leahy, David K.; Mergelsberg, Ingrid; Scholz, Ulrich; Smith, Abbie E.; Henry, Manuel; Mulder, Jason A.; Brandenburg, Jörg; Dehli, Juan R.; Fandrick, Daniel R.; Fandrick, Keith R.; Gnad-Badouin, Frieder; Zerban, Georg; Groll, Klaus; Anastas, Paul T.; Sheldon, Roger A.; Senanayake, Chris H.

doi:10.1039/c8gc00616d

Cited by 80 publications

(63 citation statements)

References 7 publications

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“…[41][42][43] They also develop tools and metrics that are published and made freely available on the website, making it easier for researchers to identify and adopt metrics that are widely accepted in industry. [44][45][46] This industrywide encouragement of research in areas of mutual interest can accelerate innovation that meets industrial needs, while allowing academia the independence needed to maintain a rigorously scientific approach.…”

Section: Recent Progressmentioning

confidence: 99%

Challenges in the development of new green solvents for polymer dissolution

Zhenova

2020

Polymer International

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As chemical legislation grows more strict and the UK moves towards a bioeconomy, acceptable solvents for industrial dissolution of polymers are growing scarce. An estimated 78% of solvent use in the EU is in sectors such as paints and coatings, printing inks and adhesives, in which polymer dissolution is a critical function. Academic research in safe, sustainable solvents is growing, but largely in the field of reaction solvents, leaving solvents for polymers underdeveloped by comparison. This challenge can be addressed through the adoption of computational tools, improved communication between industry and academia and increased research funding. Recent progress in green solvent development provides a number of models that can be adapted to the problem of polymer dissolution research. © 2020 Society of Chemical Industry

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Section: Recent Progressmentioning

confidence: 99%

Challenges in the development of new green solvents for polymer dissolution

Zhenova

2020

Polymer International

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“…This push for sustainability has emerged from the increasing global awareness of climate change and the realization of a need to shift toward processes that can sustain themselves, while keeping up with the modernization of industry and a fast-paced economy ( McElroy et al., 2015 ; Adams et al., 2013 ). This mindset comes hand-in-hand within the academic chemistry community—not only as a goal for sustainability but also as a chance for innovation and revolutionizing the way we approach and re-imagine chemical methodologies ( Roschangar et al., 2018 ). A perfect example of how green and sustainable chemistry is translating into emerging methodologies is the recent rise of new studies using organic electrosynthesis ( Yan et al., 2017 ; Yoshida et al., 2008 ).…”

Section: Introductionmentioning

confidence: 99%

Bridging Lab and Industry with Flow Electrochemistry

2020

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A revitalization of organic electrosynthesis has incited the organic chemistry community to adopt electrochemistry as a green and cost-efficient method for activating small molecules to replace highly toxic and expensive redox chemicals. However, many of the critical challenges of batch electrosynthesis, especially for organic synthesis, still remain. The combination of continuous flow technology and electrochemistry is a potent means to enable industry to implement large scale electrosynthesis. Indeed, flow electrosynthesis helps overcome problems that mainly arise from macro batch electro-organic systems, such as mass transfer, ohmic drop, and selectivity, but this is still far from being a flawless and generic applicable process. As a result, a notable increase in research on methodology and hardware sophistication has emerged, and many hitherto uncharted chemistries have been achieved. To better help the commercialization of widescale electrification of organic synthesis, we highlight in this perspective the advances made in large-scale flow electrosynthesis and its future trajectory while pointing out the main challenges and key improvements of current methodologies.

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“…Our strategy entailed determining, for each synthetic pathway, (i) waste generation (E-factor), 14,18 (ii) greenness relative to industrial benchmarks following the innovative Green Aspiration Level (iGAL™) methodology, 19,20 (iii) solvent intensity and nature according to the GSK solvent guide, 21 and (iv) score according to the Green Motion™ methodology of MANE. 22 Notwithstanding the importance of process greenness, in order to be sustainable a process must also be cost-effective and this is determined by, inter alia, the cost of raw materials and solvents and the number of unit operations.…”

Section: Introductionmentioning

confidence: 99%