Inspiratory‐cycle Instillation of Endotracheal Epinephrine in Porcine Arrest

Jasani, Melinda; Finkelstein, Mark; Hofmann, W; Salzman, Steven K.

doi:10.1111/j.1553-2712.1994.tb02640.x

Cited by 14 publications

(4 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One study in children, 246 5 studies in adults, [247][248][249][250][251] and multiple animal studies [252][253][254] have shown that lidocaine, 248,255 epinephrine, 256 atropine, 257 naloxone, and vasopressin 254 are absorbed via the trachea. There are no data regarding endotracheal administration of amiodarone.…”

Section: Endotracheal Drug Deliverymentioning

confidence: 99%

Part 8: Adult Advanced Cardiovascular Life Support

Neumar¹,

Otto²,

Link³

et al. 2010

Circulation

1,326

872

View full text Add to dashboard Cite

Section: Endotracheal Drug Deliverymentioning

confidence: 99%

Part 8: Adult Advanced Cardiovascular Life Support

Neumar¹,

Otto²,

Link³

et al. 2010

Circulation

1,326

872

View full text Add to dashboard Cite

“…They studied pulmonary epinephrine distribution, plasma epinephrine levels, return of spontaneous circulation, and post-resuscitation hemodynamics. 18 During their study they found improved bilateral epinephrine distribution in the inspiratory-cycle-timed group; however, administration by this method caused increased epinephrine adherence to the endotracheal tube. They also showed that plasma epinephrine levels rose following inspiratory-cycle-timed instillation, but there was no difference compared with the apnea group.…”

mentioning

confidence: 94%

Endotracheal Epinephrine Administration

DeBehnke

1994

Academic Emergency Medicine

View full text Add to dashboard Cite

“…Expense is another concern. There are pediatric piglet models [219,[238][239][240][241][242][243][244][245]. More work has been done in pediatric than adult ACA models likely related to the importance of ACA in children.…”

Section: Pig Aca Modelsmentioning

confidence: 99%

“…Once again, piglet CPR-related physiology mimics many aspects of the human condition. Use of piglet ACA models to optimize CPR has had excellent success for direct translation to the clinical condition [219,[238][239][240][241][242][243][244][245]. However, neuropathological targets are less defined than in rodent models and behavioral testing of piglets limited.…”

Section: Pig Aca Modelsmentioning

confidence: 99%

Brain Resuscitation in the Drowning Victim

Warner

Knape

2006

Handbook on Drowning

View full text Add to dashboard Cite

. This manuscript is dedicated to the memory of Peter Safar, M.D. Peter Safar combined genius, incredible purpose, elegance, and humanism to move the collective fields of acute medicine to a new level. His work in resuscitation medicine, critical care, anesthesiology, emergency medicine, and disaster medicine saved countless lives. As a mentor he taught us a great deal. Peter left us with an important message-in both clinical care and research: namely, to always ask, "what is your intervention or research doing for the patient?" Whether physician or scientist, it is a critical message never to forget.Portions of this manuscript are being reproduced in the Handbook of Drowning. Bierens JJ (ed.). Springer, 2nd Edition. NIH Public Access AbstractDrowning is a leading cause of accidental death. Survivors may sustain severe neurologic morbidity. There is negligible research specific to brain injury in drowning making current clinical management non-specific to this disorder. This review represents an evidence-based consensus effort to provide recommendations for management and investigation of the drowning victim. Epidemiology, brain-oriented prehospital and intensive care, therapeutic hypothermia, neuroimaging/monitoring, biomarkers, and neuroresuscitative pharmacology are addressed. When cardiac arrest is present, chest compressions with rescue breathing are recommended due to the asphyxial insult. In the comatose patient with restoration of spontaneous circulation, hypoxemia and hyperoxemia should be avoided, hyperthermia treated, and induced hypothermia (32-34 °C) considered. Arterial hypotension/hypertension should be recognized and treated. Prevent hypoglycemia and treat hyperglycemia. Treat clinical seizures and consider treating nonconvulsive status epilepticus. Serial neurologic examinations should be provided. Brain imaging and serial biomarker measurement may aid prognostication. Continuous electroencephalography and N20 somatosensory evoked potential monitoring may be considered. Serial biomarker measurement (e.g., neuron specific enolase) may aid prognostication. There is insufficient evidence to recommend use of any specific brain-oriented neuroresuscitative pharmacologic therapy other than that required to restore and maintain normal physiology. Following initial stabilization, victims should be transferred to centers with expertise in age-specific postresuscitation neurocritical care. Care should be documented, reviewed, and quality improvement assessment performed. Preclinical research should focus on models of asphyxial cardiac arrest. Clinical research should focus on improved cardiopulmonary resuscitation, re-oxygenation/ reperfusion strategies, therapeutic hypothermia, neuroprotection, neurorehabilitation, and consideration of drowning in advances made in treatment of other central nervous system disorders.

show abstract

Inspiratory‐cycle Instillation of Endotracheal Epinephrine in Porcine Arrest

Cited by 14 publications

References 20 publications

Part 8: Adult Advanced Cardiovascular Life Support

Part 8: Adult Advanced Cardiovascular Life Support

Endotracheal Epinephrine Administration

Brain Resuscitation in the Drowning Victim

Contact Info

Product

Resources

About