Insomnia mediates the longitudinal relationship between anxiety and depressive symptoms in a nationally representative sample of adolescents

Li, Y. Irina; Starr, Lisa R.; Wray‐Lake, Laura

doi:10.1002/da.22764

Cited by 30 publications

(16 citation statements)

References 83 publications

(102 reference statements)

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“…Likewise, other bridge mental states or symptoms need to be investigated as well. Currently, only two bridge mental states were assessed, while there are many other symptoms (e.g., insomnia [84]), behaviors (e.g., avoidance behaviors [85]), or cognitive processes (e.g., attributional styles [86]) that have previously been identified as shared features of depressive and anxiety disorders. Ideally, complex constructs like avoidance behavior or repetitive negative thinking would be measured using multiple items.…”

Section: Discussionmentioning

confidence: 99%

Comorbidity between depression and anxiety: assessing the role of bridge mental states in dynamic psychological networks

Groen

Ryan

Wigman

et al. 2020

BMC Med

116

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Background Comorbidity between depressive and anxiety disorders is common. A hypothesis of the network perspective on psychopathology is that comorbidity arises due to the interplay of symptoms shared by both disorders, with overlapping symptoms acting as so-called bridges, funneling symptom activation between symptom clusters of each disorder. This study investigated this hypothesis by testing whether (i) two overlapping mental states “worrying” and “feeling irritated” functioned as bridges in dynamic mental state networks of individuals with both depression and anxiety as compared to individuals with either disorder alone, and (ii) overlapping or non-overlapping mental states functioned as stronger bridges. Methods Data come from the Netherlands Study of Depression and Anxiety (NESDA). A total of 143 participants met criteria for comorbid depression and anxiety (65%), 40 participants for depression-only (18.2%), and 37 for anxiety-only (16.8%) during any NESDA wave. Participants completed momentary assessments of symptoms (i.e., mental states) of depression and anxiety, five times a day, for 2 weeks (14,185 assessments). First, dynamics between mental states were modeled with a multilevel vector autoregressive model, using Bayesian estimation. Summed average lagged indirect effects through the hypothesized bridge mental states were compared between groups. Second, we evaluated the role of all mental states as potential bridge mental states. Results While the summed indirect effect for the bridge mental state “worrying” was larger in the comorbid group compared to the single disorder groups, differences between groups were not statistically significant. The difference between groups became more pronounced when only examining individuals with recent diagnoses (< 6 months). However, the credible intervals of the difference scores remained wide. In the second analysis, a non-overlapping item (“feeling down”) acted as the strongest bridge mental state in both the comorbid and anxiety-only groups. Conclusions This study empirically examined a prominent network-approach hypothesis for the first time using longitudinal data. No support was found for overlapping mental states “worrying” and “feeling irritable” functioning as bridge mental states in individuals vulnerable for comorbid depression and anxiety. Potentially, bridge mental state activity can only be observed during acute symptomatology. If so, these may present as interesting targets in treatment, but not prevention. This requires further investigation.

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Section: Discussionmentioning

confidence: 99%

Comorbidity between depression and anxiety: assessing the role of bridge mental states in dynamic psychological networks

Groen

Ryan

Wigman

et al. 2020

BMC Med

116

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“…Additionally, meta-analytic research on adolescent insomnia suggests that insomnia is a precursor to depressive symptoms, and not vice versa (Lovato and Gradisar, 2014). Recent research on adolescents has confirmed a pathway from anxiety to depression through insomnia (Li et al, 2018b), although this study grouped types of insomnia together. Longitudinal research that examines the mechanistic progression of these disorders would greatly increase understanding of why certain sleep problems are associated with symptoms of depression and anxiety.…”

Section: Discussionmentioning

confidence: 84%

What types of insomnia relate to anxiety and depressive symptoms in late life?

Bolstad

Nadorff

2020

Heliyon

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Background: Symptoms of insomnia are associated with symptoms of depression and anxiety in older adults, yet less is known about the relation of specific forms of insomnia (i.e., onset, maintenance, and terminal insomnia) with these symptoms. This study explored how insomnia types related to symptoms of anxiety and depression in older adults. It was hypothesized that onset and maintenance insomnia would have stronger relations to anxiety and depressive symptoms than terminal insomnia. Methods: One-hundred thirty-three older adults (mean age 69, age range 65-89) were recruited using Amazon's Mechanical Turk. Participants completed the Insomnia Severity Index, Geriatric Depression Scale-Short Form, and Geriatric Anxiety Inventory-Short Form. Results: Regression analyses that controlled for the comorbidity between anxiety and depressive symptoms indicated that onset insomnia was the only independent predictor of anxiety symptoms, and maintenance insomnia was the only independent predictor of depressive symptoms, each of which had medium to large effect sizes. Limitations: Our findings are limited by an online, primarily Caucasian, and non-clinical sample as well as the cross-sectional design of the study. Conclusions: Our findings suggest that despite overlap between symptoms of depression and anxiety, insomnia may have different mechanisms of affecting each disorder. Thus, the type of insomnia is clinically relevant and should be assessed when symptoms of anxiety, depression, and/or sleep difficulties are reported.

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“…[ 7 ] When the body is in a state of tension and anxiety for a long time, the sensory function of the nervous system will be extremely sensitive, causing difficulty in falling asleep, easy to wake up, aggravating sleep disorders, forming a vicious circle. [ 8 , 9 ] Research using resting-state functional magnetic resonance imaging (rs-fMRI) suggests that insomnia is related to arousal, emotion, reward, and abnormal functional activities in cognitive brain regions. [ 10 , 11 ] It is not only related to functional abnormalities in local brain regions, but also related to abnormal internal connections of default network, prominence network, and emotional network.…”

Section: Introductionmentioning

confidence: 99%

Study on acupuncture improving insomnia comorbid with depression and anxiety based on rs-fMRI

Yao

Li²,

Cao³

et al. 2021

Medicine

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Background: Long term insomnia and low sleep quality often lead to depression, anxiety and other negative emotions, and often interact with each other. Many studies have confirmed the effectiveness of acupuncture in the treatment of insomnia comorbid with emotional disorders, but its specific mechanism needs to be further explored. Resting-state functional magnetic resonance (rsfMRI) is an important means to study the changes of brain activity. However, the results are inconsistent and lack of systematic evaluation and analysis. Methods: Nine databases will be searched, including PubMed, EMBASE, EBSCOhost-medline, Web of Science, Cochrane Library, China National Knowledge Infrastructure, VIP Database and Wan-Fang Database, Chinese Biomedical Literature Database from inception to January 2021. And screening clinical registration platform related research, in order to obtain more relevant studies. The outcomes include the change of rs-fMRI, sleep quality, depression, and anxiety. Quality assessment of the included studies will be performed according to the Cochrane Risk of Bias tool. Evidence quality will be assessed by using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) method. RevMan software (Version 5.3) and stata13.1will be used for statistical analyses. Subgroup analysis will be performed if necessary. If the data is insufficient, qualitative synthesis will be conducted instead of quantitative synthesis. Results: This study will analyze the effect of acupuncture on the brain activity changes, improvement of sleep quality and clinical symptoms of anxiety and depression with insomnia comorbid with emotional disorders. Conclusion: This study used meta-analysis method to explore the characteristics of acupuncture on brain activity changes in insomnia comorbid with emotional disorders, so as to provide effective evidence for clarifying its pathogenesis.

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Insomnia mediates the longitudinal relationship between anxiety and depressive symptoms in a nationally representative sample of adolescents

Abstract: Findings suggest that anxiety may increase risk for the development of later depression through insomnia.

Cited by 30 publications

References 83 publications

Comorbidity between depression and anxiety: assessing the role of bridge mental states in dynamic psychological networks

Comorbidity between depression and anxiety: assessing the role of bridge mental states in dynamic psychological networks

What types of insomnia relate to anxiety and depressive symptoms in late life?

Study on acupuncture improving insomnia comorbid with depression and anxiety based on rs-fMRI

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