Insomnia and Sleep Duration in a Large Cohort of Patients With Major Depressive Disorder and Anxiety Disorders

Mill, Josine G. van; Hoogendijk, Witte J.G.; Vogelzangs, Nicole; Dyck, Richard van; Penninx, Brenda W. J. H.

doi:10.4088/jcp.09m05218gry

Cited by 215 publications

(146 citation statements)

References 47 publications

(34 reference statements)

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“…The frequent co-occurrence of subjective sleep complaints and depression among kTx recipients 16 suggests that the relationship between the two conditions may be similar to the association described in the general population. [24][25][26] This highlights the clinical significance of sleep problems among kTx recipients, because they are potentially modifiable and interventions focusing on enhancing sleep may help to improve depressive symptoms. 27 Despite the significance of depression among kTx recipients and its well-known associations with sleep problems in the general population, there is a lack of information regarding the connection of depression and sleep parameters assessed by PSG among kTx recipients.…”

Section: Introductionmentioning

confidence: 99%

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Depressive Symptoms Are Associated With Objectively Measured Sleep Parameters in Kidney Transplant Recipients

Rónai

Szentkirályi

Lázár

et al. 2017

Journal of Clinical Sleep Medicine

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Study Objectives: Both depression and sleep complaints are very prevalent among kidney transplant (kTx) recipients. However, details of the complex relationship between sleep and depression in this population are not well documented. Thus, we investigated the association between depressive symptoms and sleep macrostructure parameters among prevalent kTx recipients. Methods: Ninety-five kTx recipients participated in the study (54 males, mean ± standard devation age 51 ± 13 years, body mass index 26 ± 4 kg/m 2 , estimated glomerular filtration rate 53 ± 19 ml/min/1.73 m 2 ). Symptoms of depression were assessed by the Center for Epidemiologic Studies -Depression Scale (CES-D). After 1-night polysomnography each recording was visually scored and sleep macrostructure was analyzed. Results: The CES-D score was significantly associated with the amount of stage 2 sleep (r = 0.20, P < .05), rapid eye movement (REM) latency (r = 0.21, P < .05) and REM percentage (r = −0.24, P < .05), but not with the amount of slow wave sleep (r = −0.12, P > .05). In multivariable linear regression models the CES-D score was independently associated with the amount of stage 2 sleep (β: 0.205; confidence interval: 0.001-0.409; P = .05) and REM latency (β: 0.234; confidence interval: 0.001-0.468; P = .05) after adjustment for potential confounders. I NTRO DUCTI O NDepression is one of the most prevalent mental health conditions in patients with chronic kidney disease (CKD) [1][2][3][4] ; furthermore, it is an important determinant of impaired quality of life. 5,6 Among kidney transplant (kTx) recipients, depression is associated with reduced adherence and also with increased morbidity, graft loss, and mortality. [7][8][9][10][11][12][13] Poor sleep and various sleep problems are also frequent complaints among kTx recipients.14,15 Earlier we reported that chronic insomnia was independently associated with the presence of depression in kTx recipients. 16 In the general population there is a strong and bidirectional relationship between depression and sleep.17 This is also reflected in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition definition of major depression (MD), 18 as sleep complaints are core symptoms of MD. Several objective sleep parameters are different in patients with MD than in healthy control patients. Patients with MD have decreased amounts of slow wave sleep (SWS) and shortened rapid eye movement (REM) latency with increased amounts of REM sleep. The exact mechanisms and factors that may link depression to poor clinical outcomes among kTx recipients are not yet well defined. In a recent review focusing on kTx and depression, 23 sleep is not mentioned. This may be due to the complete lack of polysomnography (PSG) studies that assess the association between sleep and depression in this population. The frequent co-occurrence of subjective sleep complaints and depression among kTx recipients 16 suggests that the relationship between the two conditions may be similar to the association described in the g...

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Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

Depressive Symptoms Are Associated With Objectively Measured Sleep Parameters in Kidney Transplant Recipients

Rónai

Szentkirályi

Lázár

et al. 2017

Journal of Clinical Sleep Medicine

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“…A primeira é o fato de a população ocupada em cargos burocráticos, possivelmente composta por indivíduos fisicamente inativos no trabalho, tender a relatar mais problemas de ansiedade e depressão associados à diminuição do sono médio. 26,27 Esses agravos também podem levar ao maior consumo de antidepressivos, aumentando o padrão do sono longo nesses indivíduos. 27 Outra hipótese seria a de que a realização de funções dependentes de esforços físicos propicia um tempo de sono mais padronizado, como consequência da AF realizada no trabalho.…”

Section: Resultsunclassified

“…26,27 Esses agravos também podem levar ao maior consumo de antidepressivos, aumentando o padrão do sono longo nesses indivíduos. 27 Outra hipótese seria a de que a realização de funções dependentes de esforços físicos propicia um tempo de sono mais padronizado, como consequência da AF realizada no trabalho. O presente estudo chama a atenção para o problema do padrão do sono longo observado nos indivíduos fisicamente inativos no trabalho, justificada pelas pesquisas que apresentam forte associação da duração do sono à presença de morbidades como diabetes, hipertensão e doenças cardíacas, 26 Estudos avaliativos da AF em seus diferentes domínios apresentam formas de mensuração, definição e nomenclatura diversas, o que dificulta comparações entre eles, indicando a necessidade de padronização dos instrumentos e critérios em estudos epidemiológicos.…”

Section: Resultsunclassified

Nível de inatividade física em diferentes domínios e fatores associados em adultos: Inquérito de Saúde no Município de Campinas (ISACamp, 2008/2009), São Paulo, Brasil

Souza

Francisco

Lima

2014

Epidemiol. Serv. Saúde

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“…6 It is also more common in patients with underlying cardiopulmonary disease. The incidence of insomnia increases with increasing age and is two to three times more prevalent in persons over the age of 65.…”

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confidence: 99%

Eszopiclone in the Management of Insomnia Among Elderly Patients

2011

Clinical Medicine Insights: Geriatrics

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Abstract:Insomnia is an increasingly common disorder in the elderly and can have a profound, negative impact on both health and quality of life. Effective management can mitigate the adverse effects on morbidity and mortality. When possible, treatment of insomnia in the elderly should focus on conservative, non-pharmaceutical strategies and control of any potential co-morbid medical or psychiatric conditions. When needed, pharmacologic agents can be both safe and effective. Several classes are available for the treatment of insomnia. However, given their efficacy, relative safety and tolerability, non-benzodiazepines such as eszopiclone should be considered the mainstay of therapy. Eszopiclone can be a safe and effective agent for the long-term treatment of insomnia in the elderly.

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Insomnia and Sleep Duration in a Large Cohort of Patients With Major Depressive Disorder and Anxiety Disorders

Cited by 215 publications

References 47 publications

Depressive Symptoms Are Associated With Objectively Measured Sleep Parameters in Kidney Transplant Recipients

Depressive Symptoms Are Associated With Objectively Measured Sleep Parameters in Kidney Transplant Recipients

Nível de inatividade física em diferentes domínios e fatores associados em adultos: Inquérito de Saúde no Município de Campinas (ISACamp, 2008/2009), São Paulo, Brasil

Eszopiclone in the Management of Insomnia Among Elderly Patients

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