Insomnia and excessive daytime sleepiness in obstructive sleep apnea: only different clinical phenotypes?

Mermigkis, Charalampos; Bouloukaki, Izolde; Schiza, Sophia

doi:10.1007/s11325-015-1170-6

Cited by 4 publications

(2 citation statements)

References 20 publications

(19 reference statements)

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“…However, this study has some limitations: the absence of sleep diagnostic tools in our context prevented us from investigating sleep apnoea itself. Nevertheless, EDS has been reported to be positively associated with obstructive sleep apnoea, 26 thus serving as a surrogate in this study. The male sex might have been underappreciated in the study as 31 of the 38 subjects who did not give their consent were males.…”

Section: Discussionmentioning

confidence: 79%

Prevalence and determinants of excessive daytime sleepiness in hypertensive patients: a cross-sectional study in Douala, Cameroon

et al. 2015

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ObjectiveTo determine the prevalence and determinants of excessive daytime sleepiness (EDS) among a group of sub-Saharan Africans living with hypertension.DesignA cross-sectional study.SettingCardiology outpatient unit of the Douala General Hospital in Cameroon.ParticipantsPatients aged 15 years and over, being followed for hypertension between 1st January and 31st July 2013. Patients with unstable heart failure, stroke and head trauma were excluded.Main outcome measureEDS was the outcome of interest. It was defined as an Epworth sleeping scale greater or equal to 10. Logistic regression was used to identify factors associated with EDS.ResultsA total of 411 patients participated in this study, with a sex ratio (male/female) of 0.58 and a mean age of 55.56 years. No patient was underweight and the mean body mass index was 30 kg/m2. Controlled blood pressure was found in 92 (22.4%) patients. The prevalence of EDS was 62.78% (95% CI 58.08 to 67.47). The factors independently associated with EDS were: type 2 diabetes (OR 2.51; 95% CI 1 to 6.29), obesity (OR 2.75; 95% CI 1.52 to 4.97), snoring (OR 7.92; 95% CI 4.43 to 14.15) and uncontrolled blood pressure (OR 4.34; 95% CI 2.24 to 8.40).ConclusionsA significant proportion of hypertensive patients suffer from EDS and present a high risk of sleep apnoea. Preventive measures targeted on weight loss, type 2 diabetes and snoring should be considered among these patients.

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Section: Discussionmentioning

confidence: 79%

Prevalence and determinants of excessive daytime sleepiness in hypertensive patients: a cross-sectional study in Douala, Cameroon

et al. 2015

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“…Além disso, o principal fator associado à SDE em indivíduos com excesso de peso seria a elevada frequência de distúrbios do sono entre indivíduos obesos [47], o que inclui, principalmente, a apneia do sono -definida por ciclos intermitentes de colapsos das vias aéreas superiores, associados a hipóxia e despertares durante o sono [44]. A apneia, por si, é uma das principais causas de SDE [48,49], o que poderia justificar os resultados do presente estudo. É importante ressaltar que, segundo estudo realizado na Noruega [32], a sonolência diurna é reportada por cerca de 30% dos profissionais da área da enfermagem.…”

Section: Discussionunclassified

Associação entre excesso de peso e sonolência diurna excessiva em trabalhadores em turnos

Santana¹

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Introduction: Studies have shown that shift workers are more likely to develop various chronic and metabolic diseases such as overweight and obesity, which one has been associated with excessive daytime sleepiness (EDS) in several studies. Objective: The aim of this study was to investigate the association between nutritional profile and excessive daytime sleepiness. Methods: We invited 258 nursing professionals from the clinical Hospital of the Federal University of Uberlandia; they were classified into three work shifts (day, night, and both shifts). Those professionals were submitted to anthropometric analysis. The Epworth Sleepiness Scale was also performed to classify the EDS of those workers. The Epworth Sleepiness Scale scores equal or greater to 10 were considered as EDS. Results: It was identified excessive daytime sleepiness in 93 (36,04%) of the workers. It was also found that individuals with excessive weight (BMI ≥ 25kg/m²) had a higher odds ratio (OR) for EDS in relation to eutrophic individuals: [OR=2,26; confidence interval (CI): 1,22-4,21; p=0,007]. Conclusion: Excessive weight nursing shift workers are more likely to have EDS. These results demonstrate the necessity for educational intervention programs to promote healthy eating and good sleep quality for these workers.

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Lack of association between MAOA-uVNTR variants and excessive daytime sleepiness

et al. 2017

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Sleep disorders are highly prevalent in the population and have dramatic health, social, and economic impacts. However, their treatments may remain symptomatic due to ignorance of molecular factors which may provide fundamental insights into the neurological bases of sleep. Excessive daytime sleepiness (EDS) is a common complaint encountered in neurological practice with significant effects both on individuals and on society. We aimed to investigate the role of monoamine oxidase A (MAOA) as a candidate gene in EDS. Epworth sleepiness scale (ESS) was applied to 221 subjects who were also genotyped for MAOA upstream variable number of tandem repeats (MAOA-uVNTR). Patient group displayed higher ESS values (mean 12.67) when compared with the control group (mean 6.38). However, MAOA-uVNTR genotypes did not show a significant association with ESS scores neither on women nor on men. Finally, these data suggest further replications in different populations. Moreover, the investigation of some other genes together with MAOA and/or some possible regulatory molecular mechanisms may offer a more comprehensive approach in the role of genetic factors contributing to EDS.

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Insomnia and excessive daytime sleepiness in obstructive sleep apnea: only different clinical phenotypes?

Cited by 4 publications

References 20 publications

Prevalence and determinants of excessive daytime sleepiness in hypertensive patients: a cross-sectional study in Douala, Cameroon

Prevalence and determinants of excessive daytime sleepiness in hypertensive patients: a cross-sectional study in Douala, Cameroon

Associação entre excesso de peso e sonolência diurna excessiva em trabalhadores em turnos

Lack of association between MAOA-uVNTR variants and excessive daytime sleepiness

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