Insilico Modeling Of FabH Of Bacillus Cereus And Conformational Study With CoA

Abstract

Pathogenic bacteria are sometimes very dangerous to humans. One among them is Bacillus cereus that causes food poisoning in human. Bacillus cereus is gram-positive bacteria that infect food items like rice, fish, raw meat and improperly cooked food. This bacterium is highly heat resistant.The fatty acid biosynthesis pathway is an attractive but still largely unexploited target for the development of new antibacterial agents. FabH, an essential enzyme for bacterial viability, catalyzes the initiation of fatty acid elongation by condensing malonyl-ACP with acetyl-CoA. Inhibitors of the condensation step of fatty acid biosynthesis represent new classes of compounds with antibiotic potential.The characteristics and the biochemical activity of FabH have been analyzed. FabH in Bacillus cereus has been studied and its structure is modeled using insilico methods. Structural analysis and comparative study is done between homologous proteins and the active site of the protein is predicted. This could be a key drug target in Bacillus cereus. FabH has been proved to be a novel drug target in various bacteriae. Similarly, in Bacillus cereus too, it could be a highly potential drug target. In future, studies on drug discovery of this particular target will be of greater use to mankind to overcome the diseases caused by Bacillus cereus.