Insights through Genetics of Halophilic Microorganisms and Their Viruses

Montalvo‐Rodríguez, Rafael; Maupin-Furlow, Julie A.

doi:10.3390/genes11040388

Cited by 4 publications

(3 citation statements)

References 13 publications

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“…Halophilic microorganisms are widely distributed in high-salt environments such as oceans, salt lakes, salt fields, and pickled foods ( Banciu et al, 2019 ; Montalvo-Rodríguez and Maupin-Furlow, 2020 ). As a microbial resource with diverse application prospects, halophils have attracted extensive attention at home and abroad because of their special physiological characteristics, metabolic capabilities, interactive community composition, and genetic resources ( Dumorné et al, 2017 ; Hasanzadeh et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Metagenomic analysis of the soil microbial composition and salt tolerance mechanism in Yuncheng Salt Lake, Shanxi Province

et al. 2022

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The soil in Yuncheng Salt Lake has serious salinization and the biogeographic environment affects the composition and distribution of special halophilic and salt-tolerant microbial communities in this area. Therefore, this study collected soils at distances of 15, 30, and 45 m from the Salt Lake and used non-saline soil (60 m) as a control to explore the microbial composition and salt tolerance mechanisms using metagenomics technology. The results showed that the dominant species and abundance of salt-tolerant microorganisms changed gradually with distance from Salt Lake. The salt-tolerant microorganisms can increase the expression of the Na+/H+ antiporter by upregulating the Na+/H+ antiporter subunit mnhA-G to respond to salt stress, simultaneously upregulating the genes in the betaine/proline transport system to promote the conversion of choline into betaine, while also upregulating the trehalose/maltose transport system encode genes to promote the synthesis of trehalose to resist a high salt environment.

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Section: Introductionmentioning

confidence: 99%

Metagenomic analysis of the soil microbial composition and salt tolerance mechanism in Yuncheng Salt Lake, Shanxi Province

et al. 2022

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“…In comparison to non-extremophilic settings, not much is known about these halophilic systems. Additional research on these viruses may eventually lead to genetic systems and a better understanding of these high-salinity microbial environments [ 65 ].…”

Section: Halophilic/alkalophilic Virusesmentioning

confidence: 99%

The Expanding Diversity of Viruses from Extreme Environments

Manuel,

Snyder

2024

IJMS

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Viruses are nonliving biological entities whose host range encompasses all known forms of life. They are deceptively simple in description (a protein shell surrounding genetic material with an occasional lipid envelope) and yet can infect all known forms of life. Recently, due to technological advancements, viruses from more extreme environments can be studied through both culture-dependent and independent means. Viruses with thermophilic, halophilic, psychrophilic, and barophilic properties are highlighted in this paper with an emphasis on the properties that allow them to exist in said environments. Unfortunately, much of this field is extremely novel and thus, not much is yet known about these viruses or the microbes they infect when compared to non-extremophilic host–virus systems. With this review, we hope to shed some light on these relatively new studies and highlight their intrinsic value.

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“…Genomic and molecular studies have revealed the differential expression of many genes involved in the biosynthesis of secondary metabolites in these organisms compared to their expression under normal conditions [ 151 , 152 ]. The obtained compounds from these fungi can potentially be used in industrial and biotechnological fields, as well as in the production of β-carotene, ectoine, and bio-rhodopsin for optical computing, and in holograms, biosensors, photoelectric devices, cosmetics, preservatives, fermented food products, the manufacturing of bioplastics and artificial retinas, bio-surfactants and exopolysaccharides, biofuels, pigments for colouring, and even bioremediation [ 153 , 154 , 155 , 156 , 157 ].…”

Section: Halophiles and Other Poly Extremophilesmentioning

confidence: 99%

The Cytotoxic Properties of Extreme Fungi’s Bioactive Components—An Updated Metabolic and Omics Overview

Kiss

Akbari

Marchev

et al. 2023

Life

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Fungi are the most diverse living organisms on planet Earth, where their ubiquitous presence in various ecosystems offers vast potential for the research and discovery of new, naturally occurring medicinal products. Concerning human health, cancer remains one of the leading causes of mortality. While extensive research is being conducted on treatments and their efficacy in various stages of cancer, finding cytotoxic drugs that target tumor cells with no/less toxicity toward normal tissue is a significant challenge. In addition, traditional cancer treatments continue to suffer from chemical resistance. Fortunately, the cytotoxic properties of several natural products derived from various microorganisms, including fungi, are now well-established. The current review aims to extract and consolidate the findings of various scientific studies that identified fungi-derived bioactive metabolites with antitumor (anticancer) properties. The antitumor secondary metabolites identified from extremophilic and extremotolerant fungi are grouped according to their biological activity and type. It became evident that the significance of these compounds, with their medicinal properties and their potential application in cancer treatment, is tremendous. Furthermore, the utilization of omics tools, analysis, and genome mining technology to identify the novel metabolites for targeted treatments is discussed. Through this review, we tried to accentuate the invaluable importance of fungi grown in extreme environments and the necessity of innovative research in discovering naturally occurring bioactive compounds for the development of novel cancer treatments.

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Insights through Genetics of Halophilic Microorganisms and Their Viruses

Cited by 4 publications

References 13 publications

Metagenomic analysis of the soil microbial composition and salt tolerance mechanism in Yuncheng Salt Lake, Shanxi Province

Metagenomic analysis of the soil microbial composition and salt tolerance mechanism in Yuncheng Salt Lake, Shanxi Province

The Expanding Diversity of Viruses from Extreme Environments

The Cytotoxic Properties of Extreme Fungi’s Bioactive Components—An Updated Metabolic and Omics Overview

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