Insights on β-cell regeneration from the zebrafish shoal: from generation of cells to functional integration

Chawla, Prateek; Silva, Luis F. Delgadillo; Ninov, Nikolay

doi:10.1016/j.cophys.2019.11.009

Cited by 1 publication

(1 citation statement)

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“…This highlights the complexity of pancreatic development across species, emphasizing the importance of understanding both similarities and differences to unravel the underlying molecular mechanisms. [4] Zebra Fish -An important model for regeneration studies Zebrafish have been widely utilized to study human diseases and the biology of vertebrates. This is a result of the model's numerous experimental advantages.…”

Section: Pancreatic Developmentmentioning

confidence: 99%

Interplay of Transcriptional Factors In Beta Cells Development and Maturation

Pillewan,

Nikam

2024

JAZ

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Diabetes is a group of metabolic disorders resulting from defects in insulin secretion, insulin action, or both. It is characterized by high blood sugar levels over a prolonged period of time with disturbances of carbohydrate, protein, and fat metabolism. It is a global disorder affecting about half a billion or 536.6 million people worldwide, which is said to rise to 783.2 million by 2045. To maintain normoglycemia, pancreatic β-cells release insulin in proportion to the amounts of nutrients in the blood. Through a process of postnatal development, β-cells learn to connect insulin release to food cues. The insulin secretory response in mature β-cells adjusts to alterations in nutritional status. The interaction between transcriptional programs specific to each cell type and external stimuli is necessary for both β-cell maturation and functional adaptation. In this review, we examine the growing data that suggests lineage-determining and signal-dependent transcription factors (LDTFs and SDTFs, respectively) work together to regulate β-cell activity during development and homeostasis. In-depth knowledge of β-cell SDTFs and their corresponding signals would clarify the processes involved in β-cell maturation and functional adaptation, directly affecting diabetes treatments and the production of mature β-cells from stem cells.

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Section: Pancreatic Developmentmentioning

confidence: 99%