Insights on the Potential Mechanisms of Action of Functional Electrical Stimulation Therapy in Combination With Task-Specific Training: A Scoping Review

Furlan, Julio C.; Pakosh, Maureen; Craven, B. Catharine; Popović, Miloš R.

doi:10.1111/ner.13403

Cited by 11 publications

(8 citation statements)

References 66 publications

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“…Passive movement therapies are mainly aimed at promoting plasticity by acting on the sensory drive to produce changes in synaptic efficacy between afferents and alpha motoneurons ( 34 ). Sophisticated body-weight supported treadmill training ( 82 , 83 ), passive cycling ( 84 ), functional electrical stimulation ( 85 ) or direct strengthening and stretching exercises ( 86 ) are employed to exercise the hindlimb. Arm- and hand-function passive exercises are, by contrast, based on the use of assisted robotics alone or in combination with neuromuscular electrical stimulation ( 87 ).…”

Section: Rehabilitative Training: An Engine For Neuroplasticitymentioning

confidence: 99%

When Spinal Neuromodulation Meets Sensorimotor Rehabilitation: Lessons Learned From Animal Models to Regain Manual Dexterity After a Spinal Cord Injury

Flores

López-Santos

García-Alías

2021

Front. Rehabilit. Sci.

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Electrical neuromodulation has strongly hit the foundations of spinal cord injury and repair. Clinical and experimental studies have demonstrated the ability to neuromodulate and engage spinal cord circuits to recover volitional motor functions lost after the injury. Although the science and technology behind electrical neuromodulation has attracted much of the attention, it cannot be obviated that electrical stimulation must be applied concomitantly to sensorimotor rehabilitation, and one would be very difficult to understand without the other, as both need to be finely tuned to efficiently execute movements. The present review explores the difficulties faced by experimental and clinical neuroscientists when attempting to neuromodulate and rehabilitate manual dexterity in spinal cord injured subjects. From a translational point of view, we will describe the major rehabilitation interventions employed in animal research to promote recovery of forelimb motor function. On the other hand, we will outline some of the state-of-the-art findings when applying electrical neuromodulation to the spinal cord in animal models and human patients, highlighting how evidences from lumbar stimulation are paving the path to cervical neuromodulation.

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Section: Rehabilitative Training: An Engine For Neuroplasticitymentioning

confidence: 99%

When Spinal Neuromodulation Meets Sensorimotor Rehabilitation: Lessons Learned From Animal Models to Regain Manual Dexterity After a Spinal Cord Injury

Flores

López-Santos

García-Alías

2021

Front. Rehabilit. Sci.

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“…9 Nowadays, functional electrical stimulation therapy protocols are used to enhance functional outcomes of physical and occupational therapy in many rehabilitation facilities across the world, even though their mechanism of action remains incompletely understood. 6,9,10 There are many other promising neuromodulation techniques being investigated for their role in motor restoration after SCI/D, including transmagnetic stimulation, transcranial direct current stimulation, brain-machine interface technology, epidural cord stimulation, and deep brain stimulation. 6,9 The potentials of assistive technology to improve individuals' independence and reduce the burden of chronic conditions (including spinal cord impairments) are the purposes of few registered studies, but those purposes are not fulfilled in many cases as assistive technology has abandonment rates between 20% and 70%.…”

Section: Maximizing Recovery After Sci or Diseasementioning

confidence: 99%

A progress report on the spinal cord rehabilitation research initiatives based on registered clinical from 2000 to 2022

Furlan

Márquez-Chin

2023

Am J Phys Med Rehabil

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The current rehabilitation therapy protocols for management of individuals with spinal cord injury or disease aim to maximize restoration of remaining function and minimize secondary health conditions. In addition, several novel rehabilitation therapies for management of spinal cord injury or disease have been reshaping the field over the past two decades. This scoping review analyzes the trends and features of the recently completed and ongoing clinical studies on the rehabilitation of individuals with spinal cord injury or disease that were registered in the ClinicalTrials.gov Website. Furthermore, this in-depth review synthesizes and appraises what was learned and what will potentially be discovered in the near future from the clinical studies on the rehabilitation after spinal cord injury or disease. To Claim CME Credits Complete the self-assessment activity and evaluation online at http://www.physiatry.org/JournalCME CME Objectives Upon completion of this article, the reader should be able to: (1) Identify the most common trends and features of research studies on spinal cord rehabilitation, which were registered in the ClinicalTrials.gov Website between 2000 and 2022; (2) Discuss the main limitations of research on spinal cord rehabilitation, based on the protocols published on the ClinicalTrials.gov Website; and (3) Recognize important knowledge gaps in clinical studies on spinal cord rehabilitation that were registered in the ClinicalTrials.gov Website. Level Advanced Accreditation The Association of Academic Physiatrists is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The Association of Academic Physiatrists designates this Journal-based CME activity for a maximum of 1.0 AMA PRA Category 1 Credit(s)™. Physicians should only claim credit commensurate with the extent of their participation in the activity.

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“…Modulation of the central nervous system is believed to play a role when applying FES for motor rehabilitation in conditions such as stroke and spinal cord injury ( 55 , 56 ). Changes in diffusion tension imaging measured with MRI, functional MRI and EEG measurements have been associated with neurological improvement after FES, when used alone or in combination with task specific training in patients with stroke ( 57 , 58 ).…”

Section: Non-invasive Peripheral Electrical Stimulationmentioning

confidence: 99%

Use of non-invasive neurostimulation for rehabilitation in functional movement disorders

Grippe

Desai

Arora

et al. 2022

Front. Rehabilit. Sci.

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Functional movement disorders (FMD) are a subtype of functional neurological disorders which involve abnormal movements and include multiple phenomenologies. There is a growing interest in the mechanism, diagnosis, and treatment of these disorders. Most of the current therapeutic approaches rely on psychotherapy and physiotherapy conducted by a multidisciplinary team. Although this approach has shown good results in some cases, FMD cause a great burden on the health system and other treatment strategies are urgently needed. In this review, we summarize past studies that have applied non-invasive neurostimulation techniques, such as transcranial magnetic stimulation (TMS), transcranial direct current stimulation (tDCS) and peripheral nerve stimulation as a treatment for FMD. There is an increasing number of studies related to TMS including randomized controlled trials; however, the protocols amongst studies are not standardized. There is only preliminary evidence for the efficacy of non-invasive neuromodulation in reducing FMD symptoms, and further studies are needed. There is insufficient evidence to allow implementation of these techniques in clinical practice.

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Insights on the Potential Mechanisms of Action of Functional Electrical Stimulation Therapy in Combination With Task-Specific Training: A Scoping Review

Cited by 11 publications

References 66 publications

When Spinal Neuromodulation Meets Sensorimotor Rehabilitation: Lessons Learned From Animal Models to Regain Manual Dexterity After a Spinal Cord Injury

When Spinal Neuromodulation Meets Sensorimotor Rehabilitation: Lessons Learned From Animal Models to Regain Manual Dexterity After a Spinal Cord Injury

A progress report on the spinal cord rehabilitation research initiatives based on registered clinical from 2000 to 2022

Use of non-invasive neurostimulation for rehabilitation in functional movement disorders

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