Insights on the NF-κB system in polycystic ovary syndrome, attractive therapeutic targets

Tan, Wei; Zhang, Jie; Dai, Fangfang; Yang, Dongyong; Gu, Ran; Tang, Lina; Liu, Hua; Cheng, Yanxiang

doi:10.1007/s11010-023-04736-w

Cited by 4 publications

(2 citation statements)

References 187 publications

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“…Blockade of TNF‐α activity decreases Th2 cytokines production, inflammatory cell infiltration and serum IgE levels 6 . TNF‐α activates the canonical (classical) pathway for nuclear factor kappa B (NF‐κB) activation 7 …”

Section: Introductionmentioning

confidence: 99%

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Immunomodulatory effect of glabridin in ovalbumin induced allergic asthma and its comparison with methylprednisolone in a preclinical rodent model

Muhammad

Salahuddin

Akhtar

et al. 2023

J of Cellular Biochemistry

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Glabridin, a polyphenolic flavonoid derived from Glycyrrhiza glabra (licorice) roots, has shown anti‐inflammatory and antioxidant properties. The current study sought to investigate glabridin's immunomodulatory effect in ovalbumin induced allergic asthma. Healthy male Wistar rats were divided into five groups. Group I served as a control group. Asthma was induced in groups II– IV. Groups III and IV were treated with glabridin (40 mg/kg) and methylprednisolone (15 mg/kg), respectively. Inflammatory cells counts were determined in blood and bronchoalveolar lavage fluid (BALF). Serum IgE levels and levels of catalase, superoxide dismutase and glutathione peroxidase in lung homogenate were measured. The levels of mRNA expression of pro‐inflammatory, anti‐inflammatory and oxidative stress markers were analysed. Delayed type hypersensitivity (DTH) and acute toxicity of glabridin were also checked. Glabridin significantly decreased inflammatory cells in the blood and BALF. It increased the concentration of antioxidant enzymes catalase, superoxide dismutase and glutathione peroxidase. Glabridin markedly decreased serum IgE levels and DTH when compared to asthmatic rats. It significantly alleviated the expression of TNF‐α, IL‐4, IL‐5, CXCL1, iNOS, and NF‐κB. Administering 10 times the therapeutic dose of glabridin did not show any signs of acute toxicity. Findings suggest that glabridin has the potential to ameliorate allergic asthma and its effects are comparable to those of methylprednisolone. The immunomodulatory effect of glabridin might be contributed by the suppression of pro‐inflammatory cytokines, oxidative stress markers, IgE antibodies, and elevation of antioxidant enzymes, suggesting future study and clinical trials to propose it as a candidate to treat allergic asthma.

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Section: Introductionmentioning

confidence: 99%

“…6 TNF-α activates the canonical (classical) pathway for nuclear factor kappa B (NF-κB) activation. 7 Inducible nitric oxide synthase (iNOS) is induced by many cytokines like IL-1β, interferon gamma (IFN-γ), IL-4, IL-13, TNF-α, and NF-κB. Severe asthma is correlated with high iNOS mRNA expression and protein levels.…”

Section: Introductionmentioning

confidence: 99%

Immunomodulatory effect of glabridin in ovalbumin induced allergic asthma and its comparison with methylprednisolone in a preclinical rodent model

Muhammad

Salahuddin

Akhtar

et al. 2023

J of Cellular Biochemistry

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Beyond defence: Immune architects of ovarian health and disease

Bazzano,

Köninger,

Solano

2024

Semin Immunopathol

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Throughout the individual’s reproductive period of life the ovary undergoes continues changes, including cyclic processes of cell death, tissue regeneration, proliferation, and vascularization. Tissue-resident leucocytes particularly macrophages, play a crucial role in shaping ovarian function and maintaining homeostasis. Macrophages crucially promote angiogenesis in the follicles and corpora lutea, thereby supporting steroidogenesis. Recent research on macrophage origins and early tissue seeding has unveiled significant insights into their role in early organogenesis, e.g. in the testis. Here, we review evidence about the prenatal ovarian seeding of leucocytes, primarily macrophages with angiogenic profiles, and its connection to gametogenesis. In the prenatal ovary, germ cells proliferate, form cysts, and undergo changes that, following waves of apoptosis, give rice to the oocytes contained in primordial follicles. These follicles constitute the ovarian reserve that lasts throughout the female’s reproductive life. Simultaneously, yolk-sac-derived primitive macrophages colonizing the early ovary are gradually replaced or outnumbered by monocyte-derived fetal macrophages. However, the cues indicating how macrophage colonization and follicle assembly are related are elusive. Macrophages may contribute to organogenesis by promoting early vasculogenesis. Whether macrophages contribute to ovarian lymphangiogenesis or innervation is still unknown. Ovarian organogenesis and gametogenesis are vulnerable to prenatal insults, potentially programming dysfunction in later life, as observed in polycystic ovary syndrome. Experimental and, more sparsely, epidemiological evidence suggest that adverse stimuli during pregnancy can program defective folliculogenesis or a diminished follicle reserve in the offspring. While the ovary is highly sensitive to inflammation, the involvement of local immune responses in programming ovarian health and disease remains to be thoroughly investigated.

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SFRP4 contributes to insulin resistance-induced polycystic ovary syndrome by triggering ovarian granulosa cell hyperandrogenism and apoptosis through the nuclear β-catenin/IL-6 signaling axis

Wang,

Gui,

et al. 2024

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

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Insights on the NF-κB system in polycystic ovary syndrome, attractive therapeutic targets

Cited by 4 publications

References 187 publications

Immunomodulatory effect of glabridin in ovalbumin induced allergic asthma and its comparison with methylprednisolone in a preclinical rodent model

Immunomodulatory effect of glabridin in ovalbumin induced allergic asthma and its comparison with methylprednisolone in a preclinical rodent model

Beyond defence: Immune architects of ovarian health and disease

SFRP4 contributes to insulin resistance-induced polycystic ovary syndrome by triggering ovarian granulosa cell hyperandrogenism and apoptosis through the nuclear β-catenin/IL-6 signaling axis

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