Insights on the endogenous labile iron pool binding properties

Condeles, André Luís; da Silva, Gabriel Simonetti; Hernandes, Maria Beatriz Braghetto; Toledo Junior, José Carlos

doi:10.1007/s10534-024-00591-4

Biometals

2024

DOI: 10.1007/s10534-024-00591-4

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Insights on the endogenous labile iron pool binding properties

André Luís Condeles,

Gabriel Simonetti da Silva,

Maria Beatriz Braghetto Hernandes

et al.

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The Ubiquity of the Reaction of the Labile Iron Pool That Attenuates Peroxynitrite-Dependent Oxidation Intracellularly

da Silva,

Hernandes,

Toledo Junior

2024

Biomolecules

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Although the labile iron pool (LIP) biochemical identity remains a topic of debate, it serves as a universal homeostatically regulated and essential cellular iron source. The LIP plays crucial cellular roles, being the source of iron that is loaded into nascent apo-iron proteins, a process akin to protein post-translational modification, and implicated in the programmed cell death mechanism known as ferroptosis. The LIP is also recognized for its reactivity with chelators, nitric oxide, and peroxides. Our recent investigations in a macrophage cell line revealed a reaction of the LIP with the oxidant peroxynitrite. In contrast to the LIP’s pro-oxidant interaction with hydrogen peroxide, this reaction is rapid and attenuates the peroxynitrite oxidative impact. In this study, we demonstrate the existence and antioxidant characteristic of the LIP and peroxynitrite reaction in various cell types. Beyond its potential role as a ubiquitous complementary or substitute protection system against peroxynitrite for cells, the LIP and peroxynitrite reaction may influence cellular iron homeostasis and ferroptosis by changing the LIP redox state and LIP binding properties and reactivity.

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The Ubiquity of the Reaction of the Labile Iron Pool That Attenuates Peroxynitrite-Dependent Oxidation Intracellularly

da Silva,

Hernandes,

Toledo Junior

2024

Biomolecules

View full text Add to dashboard Cite

show abstract

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Insights on the endogenous labile iron pool binding properties

Cited by 1 publication

References 55 publications

The Ubiquity of the Reaction of the Labile Iron Pool That Attenuates Peroxynitrite-Dependent Oxidation Intracellularly

The Ubiquity of the Reaction of the Labile Iron Pool That Attenuates Peroxynitrite-Dependent Oxidation Intracellularly

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