Insights on the Dynamic Innovative Tumor Targeted-Nanoparticles-Based Drug Delivery Systems Activation Techniques

Abstract

Anti-cancer conventional chemotherapeutic drugs novel formula progress, nowadays, uses nano technology for targeted drug delivery, specifically tailored to overcome therapeutic agents’ delivery challenges. Polymer drug delivery systems (DDS) play a crucial role in minimizing off-target side effects arising when using standard cytotoxic drugs. Using nano-formula for targeted localized action, permits using larger effective cytotoxic doses on a single special spot, that can seriously cause harm if it was administered systemically. Therefore, various nanoparticles (NPs) specifically have attached groups for targeting capabilities, not seen in bulk materials, which then need activation. In this review, we will present a simple innovative, illustrative, in a cartoon-way, enumeration of NP anti-cancer drug targeting delivery system activation-types. Area(s) covered in this review are the mechanisms of various NP activation techniques.

Iron oxide nanoparticles: a narrative review of in-depth analysis from neuroprotection to neurodegeneration

“…Therefore, there is an increased need for theranostics. 34,35 Theranostic drugs are safe, tolerable, and have both therapeutic and diagnostic potential in a single substance. Due to their distinctive characteristics and simple surface manipulation, IONPs have strong prospects for theranostic uses.…”

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“…Grade 3 and 4 neurotoxicity can be associated with somnolence, paralysis, paresthesia, spasms, ataxia, and coma. In the late 1970s, due to a lack of antiemetic drugs the chemotherapy of bleomycin, vinblastine, and cisplatin was tolerated with vomiting of even > 10 times per day as a common side effect [ 9 ]. Approved cytostatic drugs like alkylating agents, antibiotics, alkaloids, and antimetabolites were found to be associated with relatively low tumour specificity and high toxicity.…”

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