Insights on the Critical Parameters Affecting the Probiotic Viability During Stabilization Process and Formulation Development

Gurram, Sharda; Jha, Durgesh K.; Shah, Devanshi S.; Kshirsagar, Madhuri; Amin, Purnima D.

doi:10.1208/s12249-021-02024-8

Cited by 13 publications

(7 citation statements)

References 132 publications

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“…Microparticle characteristics such as size, morphology, and structure are important features for loading of bioactive agents. [ 34 ] The fabrication methods that are commonly used for designing multilayer particles include co‐extrusion, emulsion, and coating techniques ( Figure a). In this section, the benefits and limitations of each technique is described as briefly outlined in Figure 2b.…”

Section: Methods For Multilayer Microencapsulation: Operating Paramet...mentioning

confidence: 99%

Biopolymer‐Based Multilayer Microparticles for Probiotic Delivery to Colon

Talebian

Schofield

Valtchev

et al. 2022

Adv Healthcare Materials

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The potential health benefits of probiotics may not be realized because of the substantial reduction in their viability during food storage and gastrointestinal transit. Microencapsulation has been successfully utilized to improve the resistance of probiotics to critical conditions. Owing to the unique properties of biopolymers, they have been prevalently used for microencapsulation of probiotics. However, majority of microencapsulated products only contain a single layer of protection around probiotics, which is likely to be inferior to more sophisticated approaches. This review discusses emerging methods for the multilayer encapsulation of probiotic using biopolymers. Correlations are drawn between fabrication techniques and the resultant microparticle properties. Subsequently, multilayer microparticles are categorized based on their layer designs. Recent reports of specific biopolymeric formulations are examined regarding their physical and biological properties. In particular, animal models of gastrointestinal transit and disease are highlighted, with respect to trials of multilayer microencapsulated probiotics. To conclude, novel materials and approaches for fabrication of multilayer structures are highlighted.

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Section: Methods For Multilayer Microencapsulation: Operating Paramet...mentioning

confidence: 99%

Biopolymer‐Based Multilayer Microparticles for Probiotic Delivery to Colon

Talebian

Schofield

Valtchev

et al. 2022

Adv Healthcare Materials

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“…In vitro data suggested that the probiotic formulation SLAB51 can reduce nitric oxide synthesis in intestinal cells ( Ceccarelli et al, 2021 ). Studies have shown that 10 8 –10 9 CFU/g is an ideal probiotic dose for health benefits ( Gurram et al, 2021 ). Certain strains of lactic acid bacteria modulate both innate and acquired immunity when administered at an adjusted dose of 10 9 colony forming units (CFU)/day ( Roobab et al, 2020 ).…”

Section: Probiotics and Covid-19mentioning

confidence: 99%

Effective Regulation of Gut Microbiota With Probiotics and Prebiotics May Prevent or Alleviate COVID-19 Through the Gut-Lung Axis

Yang

Liu

et al. 2022

Front. Pharmacol.

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Coronavirus disease 2019 (COVID-19) can disrupt the gut microbiota balance, and patients usually have intestinal disorders. The intestine is the largest immune organ of the human body, and gut microbes can affect the immune function of the lungs through the gut-lung axis. Many lines of evidence support the role of beneficial bacteria in enhancing human immunity, preventing pathogen colonization, and thereby reducing the incidence and severity of infection. In this article, we review the possible approach of modulating microbiota to help prevent and treat respiratory tract infections, including COVID-19, and discuss the possibility of using probiotics and prebiotics for this purpose. We also discuss the mechanism by which intestinal micro-flora regulate immunity and the effects of probiotics on the intestinal micro-ecological balance. Based on this understanding, we propose the use of probiotics and prebiotics to modulate gut microbiota for the prevention or alleviation of COVID-19 through the gut-lung axis.

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“…Reproduced from ( Bodzen et al, 2020 ), C) Extrusion. Reproduced from ( Gurram et al, 2021 ), D) Electrospraying. Reproduced from ( Mendes and Chronakis, 2021 ), and E) Emulsification.…”

Section: Current Strategies For Probiotic Encapsulation and Deliverymentioning

confidence: 99%