Insights on the antitumor effects of kahweol on human breast cancer: Decreased survival and increased production of reactive oxygen species and cytotoxicity

Cárdenas, Casimiro; Quesada, Ana R.; Medina, Miguel Ángel

doi:10.1016/j.bbrc.2014.04.026

Cited by 45 publications

(33 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Coffee contains two specific diterpenes, cafestol and kahweol, which produce biologic‐effects compatible with anticarcinogenic properties, including the induction of phase II enzymes involved in carcinogen detoxification, specific inhibition of the phase I enzyme activity responsible for carcinogen activation, and stimulation of intracellular antioxidant defense mechanisms . Kahweol is an antitumor compound with inhibitory effects on tumor cell growth and survival, especially against MDA‐MB231 breast cancer cells …”

Section: Discussionmentioning

confidence: 99%

“…37 Kahweol is an antitumor compound with inhibitory effects on tumor cell growth and survival, especially against MDA-MB231 breast cancer cells. 38 In two meta-analyses, a weak or borderline inverse association was observed between coffee consumption and the risk of breast cancer overall. 8,9 Two other meta-analyses showed no association between the risk of breast cancer overall and coffee consumption, but showed statistically significant inverse associations for postmenopausal women, for BRCA1 mutation carriers, 11 and for ER2 breast cancer.…”

Section: Epidemiology Epidemiologymentioning

confidence: 99%

See 1 more Smart Citation

Prospective study of breast cancer in relation to coffee, tea and caffeine in Sweden

Sandin

Ström

et al. 2015

Intl Journal of Cancer

View full text Add to dashboard Cite

Studies of coffee and tea consumption and caffeine intake as risk factors for breast cancer are inconclusive. We assessed coffee and tea consumption, caffeine intake, and possible confounding factors among 42,099 women from the Swedish Women's Lifestyle and Health study, the participants of which were aged 30-49 years at enrollment in 1991-1992. Complete follow-up for breast cancer incidence was performed through 2012 via linkage to national registries. Poisson regression models were used to estimate relative risks (RRs) and 95% confidence intervals (CIs) for breast cancer. During follow-up 1,395 breast cancers were diagnosed. The RR was 0.97 (95% CI 0.94-0.99) for a 1-unit increase in cups of coffee/day, 1.14 (95% CI 1.05-1.24) for a 1-unit increase in cups of tea/day, and 0.97 (95% CI 0.95-1.00) for a 100 mg/day increase in caffeine intake. Although the RR for no consumption (RR 5 0.86, 95% CI 0.69-1.08), a group with a relatively small number of women, was not statistically significant, women with higher consumption had a decreased breast cancer risk (3-4 cups/day: RR 5 0.87, 95% CI 0.76-1.00; 5 cups/day: RR 5 0.81, 95% CI 0.70-0.94) compared to women consuming 1-2 cups of coffee/day. Compared to no consumption, women consuming >1 cups tea/day showed an increased breast cancer risk (RR 5 1.19, 95% CI 1.00-1.42). Similar patterns of estimates were observed for breast cancer risk overall, during pre-and postmenopausal years, and for ER1 or PR1 breast cancer, but not for ER2 and PR2 breast cancer. Our findings suggest that coffee consumption and caffeine intake is negatively associated with the risk of overall and ER1/PR2 breast cancer, and tea consumption is positively associated with the risk of overall and ER1/PR1 breast cancer.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Epidemiology Epidemiologymentioning

confidence: 99%

Prospective study of breast cancer in relation to coffee, tea and caffeine in Sweden

Sandin

Ström

et al. 2015

Intl Journal of Cancer

View full text Add to dashboard Cite

show abstract

“…Apart from human colorectal cancer, kahweol has anti-cancer properties against oral squamous cancer (Chae et al ., 2014), breast cancer (Cardenas et al ., 2014), pleural mesothelioma (Lee et al ., 2012), renal carcinoma (Um et al ., 2010) and lung cancer (Kim et al ., 2009). In mechanistic studies for apoptotic effect of kahweol, it stimulated the cleavage of caspase-3 and poly ADP-ribose polymerase (PARP) by inhibiting the phosphorylation of a signal transducer and activator of transcription 3 (STAT3) in lung adenocarcinoma cells (Kim et al ., 2009).…”

Section: Introductionmentioning

confidence: 99%

Kahweol from Coffee Induces Apoptosis by Upregulating Activating Transcription Factor 3 in Human Colorectal Cancer Cells

Park

Song

Jeong

2017

Biomolecules & Therapeutics

View full text Add to dashboard Cite

Kahweol as a coffee-specific diterpene has been reported to induce apoptosis in human cancer cells. Although some molecular targets for kahweol-mediated apoptosis have been elucidated, the further mechanism for apoptotic effect of kahweol is not known. Activating transcription factor 3 (ATF3) has been reported to be associated with apoptosis in colorectal cancer. The present study was performed to investigate the molecular mechanism by which kahweol stimulates ATF3 expression and apoptosis in human colorectal cancer cells. Kahweol increased apoptosis in human colorectal cancer cells. It also increased ATF3 expression through the transcriptional activity. The responsible cis-element for ATF3 transcriptional activation by kahweol was CREB located between −147 to −85 of ATF3 promoter. ATF3 overexpression increased kahweol-mediated cleaved PARP, while ATF3 knockdown attenuated the cleavage of PARP by kahweol. Inhibition of ERK1/2 and GSK3β blocked kahweol-mediated ATF3 expression. The results suggest that kahweol induces apoptosis through ATF3-mediated pathway in human colorectal cancer cells.

show abstract

“…The dual effects of phytoestrogens (genistein, daizein, and 8-prenylnaringenin) on OCLs and OBL are thought to be due to the inhibition of estrogen receptor-mediated events, whereas those of other flavonoids (resveratrol, quercetin, and fisetin) are mediated by antioxidant effects. Considering that kahweol inhibits tumor cell proliferation in the estrogen receptor-negative human breast cancer MDA-MB231 cells [36], the dual effects of cafestol may be mediated by antioxidants. The precise molecular target(s) of cafestol and kahweol remains unknown.…”

Section: Discussionmentioning

confidence: 99%

Cafestol has a weaker inhibitory effect on osteoclastogenesis than kahweol and promotes osteoblast differentiation

et al. 2015

View full text Add to dashboard Cite

Bone homeostasis is regulated by a balance between osteoclast (OCL)-mediated bone resorption and osteoblast (OBL)-mediated bone formation. Thus, developing a compound that simultaneously inhibits OCL function and promotes OBL function would be useful as a new medical therapy for bone diseases. Here, we examined the effects of cafestol, a coffee diterpene, on the differentiation of OCLs and OBLs. Cafestol prevented OCL formation in a dose-dependent manner and suppressed the bone-resorbing activity of OCLs. Interestingly, the viability of OCLs treated with 10-50 µM cafestol was significantly higher than that of untreated cells. At the molecular level, cafestol markedly decreased RANKL-induced phosphorylation of extracellular signal-regulated kinase (Erk) and inhibitor of nuclear factor kappa B alpha (IκBα). Compared to kahweol, another coffee-specific diterpene, the inhibitory effects of cafestol were milder on OCL differentiation, and cafestol and kahweol showed different characteristics in induction of the phase ΙΙ antioxidant enzymes and sensitivities in nuclear factor-erythroid 2-related factor 2 (Nrf2)-deficient BMMs. In addition to inhibiting OCLs, cafestol enhanced the differentiation of osteoblastic cells by increasing the mRNA levels of differentiation markers. Thus, cafestol inhibits OCL differentiation and promotes OBL differentiation, suggesting that cafestol may be a novel agent for bone diseases.

show abstract

Insights on the antitumor effects of kahweol on human breast cancer: Decreased survival and increased production of reactive oxygen species and cytotoxicity

Cited by 45 publications

References 27 publications

Prospective study of breast cancer in relation to coffee, tea and caffeine in Sweden

Prospective study of breast cancer in relation to coffee, tea and caffeine in Sweden

Kahweol from Coffee Induces Apoptosis by Upregulating Activating Transcription Factor 3 in Human Colorectal Cancer Cells

Cafestol has a weaker inhibitory effect on osteoclastogenesis than kahweol and promotes osteoblast differentiation

Contact Info

Product

Resources

About