Insights on magnetic spinel ferrites for targeted drug delivery and hyperthermia applications

Maksoud, M. I. A. Abdel; El-Sayyad, Gharieb S.; Kodous, Ahmad S.; Fahim, Ramy Amer; Osman, Ahmed I.; Al-Muhtaseb, Ala’a H.; Rooney, David; Mamdouh, Mohamed A; Nady, Norhan; Ashour, Ahmed

doi:10.1515/ntrev-2022-0027

Cited by 50 publications

(21 citation statements)

References 221 publications

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“…20 Based on their crystal lattice structure, ferrites can be classified into four different types, garnet ferrites (GFs), hexaferrites (HFs), ortho -ferrites (OFs), and spinel ferrites (SFs). 21 However, based on their magnetic properties, ferrites are also classified into two categories, hard ferrites and soft ferrites. 22,23 Typically, hard ferrites (space group P 63/ mmc ) have a hexagonal crystal structure, such as HFs.…”

Section: Introductionmentioning

confidence: 99%

Green synthesis of M-type manganese-substituted strontium hexaferrite SrMn_xFe_12−xO₁₉ nanoparticles with intrinsic antibacterial activity against human pathogenic bacteria

Hamarawf,

Tofiq,

Omer

2023

New J. Chem.

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Section: Introductionmentioning

confidence: 99%

Green synthesis of M-type manganese-substituted strontium hexaferrite SrMn_xFe_12−xO₁₉ nanoparticles with intrinsic antibacterial activity against human pathogenic bacteria

Hamarawf,

Tofiq,

Omer

2023

New J. Chem.

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“…Depending on where the cancer cells are, it is divided into three categories: whole body, regional, and local hyperthermia. Due to the fact that cancer cells are more vulnerable to the effects of hyperthermia than normal cells, hyperthermia is regarded as a targeted differential treatment . The energy is absorbed by the supermagnetic SFNPs by an alternating external magnetic field and is then released as heat through a magnetic relaxation process, or hysteresis .…”

Section: Environmental Feasibilitymentioning

confidence: 99%

Ferrite-Supported Nanocomposite Polymers for Emerging Organic and Inorganic Pollutants Removal from Wastewater: A Review

Karthik,

Dhivya Dharshini,

Senthil Kumar

et al. 2023

Ind. Eng. Chem. Res.

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In recent years, organic and inorganic contaminants in wastewater (heavy metals, halides, nutrients, dyes, and pathogenrelated water pollution) have become a major global problem. There were initially fewer toxins, but as a result of fast industrialization and other human activities, they have rapidly risen. In addition to producing a host of health problems and organ system failure in people, these toxins have had a disastrous effect on the ecological balance of plants, animals, and even microbes. On the basis of nanotechnology, several methods for decontaminating water that use nanoadsorbents and/or photocatalysts are being researched. Due to their improved physical and chemical characteristics, several research studies have focused on the elimination of organic and inorganic pollutants using ferritesupported nanocomposite polymers as possible affordable substitutes for currently employed materials. In this review, the toxicity of heavy metals and the different adsorption capabilities of metal-doped ferrites, which are employed to detect the pollutants in wastewater, are discussed in detail. Also, it provides various synthesis methods to produce ferrite-supported polymer-based nanocomposites and a current review of them with a special emphasis on their exceptional ability to remove organic and inorganic pollutants from wastewater. As a result, ferrite-supported polymer-based nanocomposites, which are also less expensive and swellable, can act as effective adsorbents for the removal of both organic and inorganic pollutants. It has outstanding performance for sizes between 10 and 30 nm.

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“…The magnetic properties of the MZFs are strongly dependent on the phase purity, microstructure, morphology (size, shape and particle size distribution) and the types and amount of dopants [ 15 ]. MZFs have diverse biotechnical applications, such as cancer cell diagnosis [ 16 ], drug delivery [ 17 ], tumor imaging and the treatment of cancer cells [ 18 ]. Superparamagnetic MZF nanoparticles can increase water proton relaxation rates in tissue, which makes them promising candidates for MRI contrast agents [ 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of Europium Substitution on the Structural, Magnetic and Relaxivity Properties of Mn-Zn Ferrite Nanoparticles: A Dual-Mode MRI Contrast-Agent Candidate

et al. 2023

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Magnetic nanoparticles (MNPs) have been widely applied as magnetic resonance imaging (MRI) contrast agents. MNPs offer significant contrast improvements in MRI through their tunable relaxivities, but to apply them as clinical contrast agents effectively, they should exhibit a high saturation magnetization, good colloidal stability and sufficient biocompatibility. In this work, we present a detailed description of the synthesis and the characterizations of europium-substituted Mn–Zn ferrite (Mn0.6Zn0.4EuxFe2−xO4, x = 0.00, 0.02, 0.04, 0.06, 0.08, 0.10, and 0.15, herein named MZF for x = 0.00 and EuMZF for others). MNPs were synthesized by the coprecipitation method and subsequent hydrothermal treatment, coated with citric acid (CA) or pluronic F127 (PF-127) and finally characterized by X-Ray Diffraction (XRD), Inductively Coupled Plasma (ICP), Vibrating Sample Magnetometry (VSM), Fourier-Transform Infrared (FTIR), Dynamic Light Scattering (DLS) and MRI Relaxometry at 3T methods. The XRD studies revealed that all main diffraction peaks are matched with the spinel structure very well, so they are nearly single phase. Furthermore, XRD study showed that, although there are no significant changes in lattice constants, crystallite sizes are affected by europium substitution significantly. Room-temperature magnetometry showed that, in addition to coercivity, both saturation and remnant magnetizations decrease with increasing europium substitution and coating with pluronic F127. FTIR study confirmed the presence of citric acid and poloxamer (pluronic F127) coatings on the surface of the nanoparticles. Relaxometry measurements illustrated that, although the europium-free sample is an excellent negative contrast agent with a high r2 relaxivity, it does not show a positive contrast enhancement as the concentration of nanoparticles increases. By increasing the europium to x = 0.15, r1 relaxivity increased significantly. On the contrary, europium substitution decreased r2 relaxivity due to a reduction in saturation magnetization. The ratio of r2/r1 decreased from 152 for the europium-free sample to 11.2 for x = 0.15, which indicates that Mn0.6Zn0.4Eu0.15Fe1.85O4 is a suitable candidate for dual-mode MRI contrast agent potentially. The samples with citric acid coating had higher r1 and lower r2 relaxivities than those of pluronic F127-coated samples.

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Insights on magnetic spinel ferrites for targeted drug delivery and hyperthermia applications

Cited by 50 publications

References 221 publications

Green synthesis of M-type manganese-substituted strontium hexaferrite SrMn_xFe_12−xO₁₉ nanoparticles with intrinsic antibacterial activity against human pathogenic bacteria

Green synthesis of M-type manganese-substituted strontium hexaferrite SrMn_xFe_12−xO₁₉ nanoparticles with intrinsic antibacterial activity against human pathogenic bacteria

Ferrite-Supported Nanocomposite Polymers for Emerging Organic and Inorganic Pollutants Removal from Wastewater: A Review

Effect of Europium Substitution on the Structural, Magnetic and Relaxivity Properties of Mn-Zn Ferrite Nanoparticles: A Dual-Mode MRI Contrast-Agent Candidate

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Insights on magnetic spinel ferrites for targeted drug delivery and hyperthermia applications

Cited by 50 publications

References 221 publications

Green synthesis of M-type manganese-substituted strontium hexaferrite SrMnxFe12−xO19 nanoparticles with intrinsic antibacterial activity against human pathogenic bacteria

Green synthesis of M-type manganese-substituted strontium hexaferrite SrMnxFe12−xO19 nanoparticles with intrinsic antibacterial activity against human pathogenic bacteria

Ferrite-Supported Nanocomposite Polymers for Emerging Organic and Inorganic Pollutants Removal from Wastewater: A Review

Effect of Europium Substitution on the Structural, Magnetic and Relaxivity Properties of Mn-Zn Ferrite Nanoparticles: A Dual-Mode MRI Contrast-Agent Candidate

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Green synthesis of M-type manganese-substituted strontium hexaferrite SrMn_xFe_12−xO₁₉ nanoparticles with intrinsic antibacterial activity against human pathogenic bacteria

Green synthesis of M-type manganese-substituted strontium hexaferrite SrMn_xFe_12−xO₁₉ nanoparticles with intrinsic antibacterial activity against human pathogenic bacteria