Insights on limits of detection, precision and accuracy in TXRF analysis of trace and major elements in environmental solid suspensions

Espinoza‐Quiñones, Fernando Rodolfo; Módenes, Aparecido Nivaldo; Santos, Joelmir dos; Obregón, Phallcha Luízar; Pauli, Aline Roberta de

doi:10.1016/j.apradiso.2018.03.016

Cited by 15 publications

(3 citation statements)

References 34 publications

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“…Two different types of sample preparation methodologies (e.g., suspension of powdered materials and touchstone technique) were employed for the direct solid analysis of the MOX fuel pellets. 2,17 We have developed a methodology that allows for the use of the universal calibration/ relative sensitivity for elemental quantication of various samples, without the need for matrix-matched standards. Moreover, this methodology allows us to avoid the cumbersome dissolution steps, along with avoiding handling of corrosive chemicals like HF or HNO 3 2 .…”

Section: Introductionmentioning

confidence: 99%

A green analytical approach for the direct non-destructive compositional analysis of (Th, U)O₂ fuel pellets by the X-Ray Fluorescence technique using single universal calibration

Kanrar

Sanyal

Pai

2022

J. Anal. At. Spectrom.

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Section: Introductionmentioning

confidence: 99%

A green analytical approach for the direct non-destructive compositional analysis of (Th, U)O₂ fuel pellets by the X-Ray Fluorescence technique using single universal calibration

Kanrar

Sanyal

Pai

2022

J. Anal. At. Spectrom.

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“…The feasibility of such approach has recently been confirmed by Espinoza-Quiñones et al [38] who investigated several matrix reference materials applying solid suspensions prepared by using pure water. Agreeable precision and accuracy, as well as sufficient limits of detection for trace and major elements, were obtained by TXRF analysis, whereas Marguí et al [21] found minor recoveries in comparison with ICP-OES analysis of digests when suspending dried and grinded human placenta in surfactant-containing water for TXRF analysis.…”

Section: Optimization Of Sample Preparationmentioning

confidence: 91%

Total reflection X-ray fluorescence spectrometry for trace determination of iron and some additional elements in biological samples

et al. 2020

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Trace elements are essential for life and their concentration in cells and tissues must be tightly maintained and controlled to avoid pathological conditions. Established methods to measure the concentration of trace elements in biological matrices often provide only single element information, are time-consuming, and require special sample preparation. Therefore, the development of straightforward and rapid analytical methods for enhanced, multi-trace element determination in biological samples is an important and raising field of trace element analysis. Herein, we report on the development and validation of a reliable method based on total reflection X-ray fluorescence (TXRF) analysis to precisely quantify iron and other trace metals in a variety of biological samples, such as the liver, parenchymal and non-parenchymal liver cells, and bone marrow-derived macrophages. We show that TXRF allows fast and simple one-point calibration by addition of an internal standard and has the potential of multi-element analysis in minute sample amounts. The method was validated for iron by recovery experiments in homogenates in a wide concentration range from 1 to 1600 μg/L applying well-established graphite furnace atomic absorption spectrometry (GFAAS) as a reference method. The recovery rate of 99.93 ± 0.14% reveals the absence of systematic errors. Furthermore, the standard reference material "bovine liver" (SRM 1577c, NIST) was investigated in order to validate the method for further biometals. Quantitative recoveries (92-106%) of copper, iron, zinc, and manganese prove the suitability of the developed method. The limits of detection for the minute sample amounts are in the low picogram range. Keywords Total reflection X-ray fluorescence spectrometry. Iron trace analysis. Biometal trace analysis. Bone marrow-derived macrophages. Liver cells. Liver tissues Published in the topical collection featuring Female Role Models in Analytical Chemistry.

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“…frequently appearing validation parameters for quantitative elemental analyses are the accuracy and precision of the measurement as well as the detection limit of the determined elements [10][11][12][13] .…”

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The assessment of the usability of selected instrumental techniques for the elemental analysis of biomedical samples

Planeta

Kubala‐Kukuś

Dróżdż

et al. 2021

Sci Rep

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The fundamental role of major, minor and trace elements in different physiological and pathological processes occurring in living organism makes that elemental analysis of biomedical samples becomes more and more popular issue. The most often used tools for analysis of the elemental composition of biological samples include Flame and Graphite Furnace Atomic Absorption Spectroscopy (F-AAS and GF-AAS), Inductively Coupled Plasma Optical Emission Spectroscopy (ICP-OES) and Inductively Coupled Plasma Mass Spectrometry (ICP-MS). Each of these techniques has many advantages and limitations that should be considered in the first stage of planning the measurement procedure. Their reliability can be checked in the validation process and the precision, trueness and detection limits of elements belong to the most frequently determined validation parameters. The main purpose of this paper was the discussion of selected instrumental techniques (F-AAS, GF-AAS, ICP-OES and ICP-MS) in term of the achieved validation parameters and the usefulness in the analysis of biological samples. The focus in the detailed literature studies was also put on the methods of preparation of the biomedical samples. What is more based on the own data the usefulness of the total reflection X-ray fluorescence spectroscopy for the elemental analysis of animal tissues was examined. The detection limits of elements, precision and trueness for the technique were determined and compared with the literature data concerning other of the discussed techniques of elemental analysis. Reassuming, the following paper is to serve as a guide and comprehensive source of information concerning the validation parameters achievable in different instrumental techniques used for the elemental analysis of biomedical samples.

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Insights on limits of detection, precision and accuracy in TXRF analysis of trace and major elements in environmental solid suspensions

Cited by 15 publications

References 34 publications

A green analytical approach for the direct non-destructive compositional analysis of (Th, U)O₂ fuel pellets by the X-Ray Fluorescence technique using single universal calibration

A green analytical approach for the direct non-destructive compositional analysis of (Th, U)O₂ fuel pellets by the X-Ray Fluorescence technique using single universal calibration

Total reflection X-ray fluorescence spectrometry for trace determination of iron and some additional elements in biological samples

The assessment of the usability of selected instrumental techniques for the elemental analysis of biomedical samples

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Insights on limits of detection, precision and accuracy in TXRF analysis of trace and major elements in environmental solid suspensions

Cited by 15 publications

References 34 publications

A green analytical approach for the direct non-destructive compositional analysis of (Th, U)O2 fuel pellets by the X-Ray Fluorescence technique using single universal calibration

A green analytical approach for the direct non-destructive compositional analysis of (Th, U)O2 fuel pellets by the X-Ray Fluorescence technique using single universal calibration

Total reflection X-ray fluorescence spectrometry for trace determination of iron and some additional elements in biological samples

The assessment of the usability of selected instrumental techniques for the elemental analysis of biomedical samples

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A green analytical approach for the direct non-destructive compositional analysis of (Th, U)O₂ fuel pellets by the X-Ray Fluorescence technique using single universal calibration

A green analytical approach for the direct non-destructive compositional analysis of (Th, U)O₂ fuel pellets by the X-Ray Fluorescence technique using single universal calibration