Insights on catheter-related bloodstream infections: a prospective observational study on the catheter colonization and multidrug resistance

Pinto, Miguel; Borges, Vítor; Nascimento, Maria; Martins, Filomena; Pessanha, Maria Ana; Faria, Isabel; Rodrigues, João; Matias, Rui; Gomes, João Paulo; Jordão, Luísa

doi:10.1016/j.jhin.2022.01.025

Cited by 6 publications

(8 citation statements)

References 36 publications

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“…Several studies reported a positive correlation between the presence of icaAD genes and the ability of Staphylococcus strains to produce a biofilm [275][276][277]. However, Pinto et al [261] showed no relationship between the presence/absence of the ica operon and biofilm formation on CVCs. Another recent study showed that 4/6 S. aureus strains, that did not carry ica genes, were strong biofilm producers [278].…”

Section: Staphylococcus Aureusmentioning

confidence: 99%

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Medical Device-Associated Biofilm Infections and Multidrug-Resistant Pathogens

Bouhrour,

Nibbering,

Bendali

2024

Pathogens

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Medical devices such as venous catheters (VCs) and urinary catheters (UCs) are widely used in the hospital setting. However, the implantation of these devices is often accompanied by complications. About 60 to 70% of nosocomial infections (NIs) are linked to biofilms. The main complication is the ability of microorganisms to adhere to surfaces and form biofilms which protect them and help them to persist in the host. Indeed, by crossing the skin barrier, the insertion of VC inevitably allows skin flora or accidental environmental contaminants to access the underlying tissues and cause fatal complications like bloodstream infections (BSIs). In fact, 80,000 central venous catheters—BSIs (CVC-BSIs)—mainly occur in intensive care units (ICUs) with a death rate of 12 to 25%. Similarly, catheter-associated urinary tract infections (CA-UTIs) are the most commonlyhospital-acquired infections (HAIs) worldwide. These infections represent up to 40% of NIs.In this review, we present a summary of biofilm formation steps. We provide an overview of two main and important infections in clinical settings linked to medical devices, namely the catheter-asociated bloodstream infections (CA-BSIs) and catheter-associated urinary tract infections (CA-UTIs), and highlight also the most multidrug resistant bacteria implicated in these infections. Furthermore, we draw attention toseveral useful prevention strategies, and advanced antimicrobial and antifouling approaches developed to reduce bacterial colonization on catheter surfaces and the incidence of the catheter-related infections.

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Section: Staphylococcus Aureusmentioning

confidence: 99%

“…In the study of Bonnal et al [260], 56% of S. aureus in PVC-BSIs and 34% of S. aureus in CVC-BSIs were identified. Recently, Pinto et al [261] identified S. aureus as the main causative agent of CR-BSIs with a rate of 24.1%. Other studies [85,175,222,258,[262][263][264][265][266] also reported implication of S. aureus in CR-BSIs.…”

Section: Staphylococcus Aureusmentioning

confidence: 99%

Medical Device-Associated Biofilm Infections and Multidrug-Resistant Pathogens

Bouhrour,

Nibbering,

Bendali

2024

Pathogens

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“…Polymers play an important role in preparing medical material and are widely used in the medical field [1][2][3][4][5][6][7]. Sometimes they are not fully suitable for the clinical applications as using for interventional materials and infecting by bacteria susceptibly, resulting in catheter-related bloodstream infections (CRBSI) [8][9][10]. For instance, central venous catheter (CVC) and peripheral intravenous central catheter are made of PU and the occurring rate of CRBSI is from 3% to 8% with the increasing of retention-time extending.…”

Section: Introductionmentioning

confidence: 99%

Non-soluble antibacterial polyurethane based on cation mechanism and functionalized by chitosan and heparin azide

Li,

Zhang,

Liu

et al. 2024

Biomed. Mater.

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Nowadays, medical polyurethanes with favorable and durable antibacterial properties received more attention, because of avoiding repeated replacement of interventional materials and reducing patients’ pain. In this thesis, non-soluble antibacterial polyurethane (NAPU) based on cation antibacterial mechanism was prepared by photo-grafting chitosan azide and heparin azide into polyurethane (PU). –NH3 + of chitosan azide absorbed bacteria, inhibiting and breaking their mobility and structures. Heparin azide prevented cations from penetrating bacteria’s membranes and inhibited their growth. The results showed that chitosan azide and heparin azide were successfully grafted into PU. The highest antibacterial rate was 92.07%, cytotoxicity grade ranging from 0–1 (RGR standard) and water contact angle exhibiting 60°, attributing to cation antibacterial effect and –OH existing. Tensile strength was up to 23.91 MPa and was suitable for using as medical materials. NAPU with long-lasting coating both possessed antibacterial properties and persistence, which can solve the problem of medical catheters’ long-term using.

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“…[ 1 ]. Several studies reported the occurrence of polymicrobial CRBSI, as well as the increase in their incidence [ 4 , 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Resistance and Biofilms Underlying Catheter-Related Bloodstream Coinfection by Enterobacter cloacae Complex and Candida parapsilosis

et al. 2022

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Biofilm-associated infections are a public health concern especially in the context of healthcare-associated infections such as catheter-related bloodstream infections (CRBSIs). We evaluated the biofilm formation and antimicrobials resistance (AMR) of Enterobacter cloacae complex and Candida parapsilosis co-isolated from a CRBSI patient. Antimicrobial susceptibility of central venous catheters (CVCs) and hemoculture (HC) isolates was evaluated, including whole genome sequencing (WGS) resistome analysis and evaluation of gene expression to obtain insight into their AMR determinants. Crystal violet assay was used to assess dual biofilm biomass and microscopy was used to elucidate a microorganism’s distribution within biofilms assembled on different materials. Bacteria were multidrug-resistant including resistance to colistin and beta-lactams, likely linked to the mcr-9-like phosphoethanolamine transferase and to an ACT family cephalosporin-hydrolyzing class C beta-lactamase, respectively. The R398I and Y132F mutations in the ERG11 gene and its differential expression might account for C. parapsilosis resistance to fluconazole. The phenotype of dual biofilms assembled on glass, polystyrene and polyurethane depends on the material and how biofilms were initiated by one or both pathogens. Biofilms assembled on polyurethane were denser and richer in the extracellular polymeric matrix, and microorganisms were differently distributed on the inner/outer surface of the CVC.

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Insights on catheter-related bloodstream infections: a prospective observational study on the catheter colonization and multidrug resistance

Cited by 6 publications

References 36 publications

Medical Device-Associated Biofilm Infections and Multidrug-Resistant Pathogens

Medical Device-Associated Biofilm Infections and Multidrug-Resistant Pathogens

Non-soluble antibacterial polyurethane based on cation mechanism and functionalized by chitosan and heparin azide

Antimicrobial Resistance and Biofilms Underlying Catheter-Related Bloodstream Coinfection by Enterobacter cloacae Complex and Candida parapsilosis

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