Insights of lyotropic liquid crystals in topical drug delivery for targeting various skin disorders

Rapalli, Vamshi Krishna; Waghule, Tejashree; Hans, Neha; Mahmood, Arisha; Gorantla, Srividya; Dubey, Sunil Kumar; Singhvi, Gautam

doi:10.1016/j.molliq.2020.113771

Cited by 61 publications

(32 citation statements)

References 62 publications

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“…Hence delivery of miRNAs through topical route can be used for treating several skin diseases. Topical delivery of miRNA can be brought about by using different techniques and carriers such as cell‐penetrating peptides, spherical nucleic acid‐gold nanoparticles, deformable liposomes, liquid crystalline nanoparticles, and so on 36,37 . The schematic representation of miRNA permeation through psoriasis skin condition is represented in Figure 2.…”

Section: Topical Delivery Of Mirna For Psoriasismentioning

confidence: 99%

Insightful exploring of microRNAs in psoriasis and its targeted topical delivery

Pradyuth

Rapalli

Gorantla

et al. 2020

Dermatologic Therapy

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Psoriasis is a common immune-mediated inflammatory skin disease. It includes multifaceted interaction between the immune system and the keratinocytes. Recent studies depicted the role of microRNAs (miRNAs) in hyperproliferation of keratinocytes and inflammatory cytokine production, which serve as biomarkers for diagnosis, monitoring treatment response, and prognosis. miRNAs are small nucleotide sequenced noncoding RNAs. Deregulation of miRNAs was found to be the most common factor in the studies pertaining to psoriasis. Hence, miRNA-based targeting for psoriasis treatment became the primary field of current research. miRNA due to its spatial and chemical properties offer different challenges in the process of its delivery. The topical delivery of different siRNAs and genes has paved a way to similar delivery of miRNA. The topical delivery of miRNAs to the skin can bring a revolutionary change in the field of psoriasis treatment.

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Section: Topical Delivery Of Mirna For Psoriasismentioning

confidence: 99%

Insightful exploring of microRNAs in psoriasis and its targeted topical delivery

Pradyuth

Rapalli

Gorantla

et al. 2020

Dermatologic Therapy

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“…Lyotropic LCs (or lyomesophases) consisting of amphiphiles have a tendency to form self-assembled structures depending on their concentration in solution. The physicochemical properties of lyotropic LCs and their intrinsic structures, including lamellar, hexagonal, and cubic phases, make them suitable as drug delivery agents in pharmaceutical sciences in a wide range of applications [ 11 , 12 , 13 , 14 , 15 , 16 ]. In particular, the hexagonal and cubic phases are of high interest in the field of drug delivery agents owing to their ability to control or maintain the release of hydrophilic and hydrophobic drug molecules with a wide range of molecular weights [ 17 , 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Vertical Alignment of Liquid Crystal on Sustainable 2,4-Di-tert-butylphenoxymethyl-Substituted Polystyrene Films

2022

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We synthesized sustainable 2,4-di-tert-butylphenoxymethyl-substituted polystyrenes (PDtBP#, # = 88, 68, 35, and 19, where # is molar percent contents of 2,4-di-tert-butylphenoxymethyl moiety), using post-polymerization modification reactions in order to study their liquid crystal (LC) alignment behaviors. In general, LC cells fabricated using polymer film with higher molar content of 2,4-di-tert-butylphenoxymethyl side groups showed vertical LC alignment behavior. LC alignment behavior in LC cell was related to the surface energy of the polymer alignment layer. For example, when the total surface energy value of the polymer layer was smaller than about 29.4 mJ/m2, vertical alignment behaviors were observed, generated by the nonpolar 2,4-di-tert-butylphenoxymethyl moiety with long and bulky carbon groups. Orientation stability was observed at 200 °C in the LC cells fabricated using PDtBP88 as the LC alignment layer. Therefore, as a natural compound modified polymer, PDtBP# can be used as a candidate LC alignment layer for environmentally friendly applications.

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“…In addition to the traditional emulsion system, in which droplets of oil are emulsified by a surfactant and dispersed in water or droplets of water are emulsified by surfactant and dispersed in an oil phase, liquid crystal emulsion is a recent type of emulsion in which the surfactant and oil molecules are in an ordered array at the oil–water interface 17 . Lamellar liquid crystals (LLCs) are also known as layered envelopes of uneven disc-like micelles where the surfactant molecules are attached tail to tail and manipulated in flat layers encountering the water layers 18 . LLCs have presented preferable application performance, including greater effectiveness in the skin whitening effect and higher skin retention of active compounds 18 .…”

Section: Introductionmentioning

confidence: 99%

“…Lamellar liquid crystals (LLCs) are also known as layered envelopes of uneven disc-like micelles where the surfactant molecules are attached tail to tail and manipulated in flat layers encountering the water layers 18 . LLCs have presented preferable application performance, including greater effectiveness in the skin whitening effect and higher skin retention of active compounds 18 . The structure of LLCs is arranged similarly to lipids in the cell membrane and intercellular space of the stratum corneum; hence, the enhanced efficacy of LLCs is due to the improved permeability of the active compounds because of the interaction between intercellular lipids in the stratum corneum and LLC emulsifier 18 , 19 .…”

Section: Introductionmentioning

confidence: 99%

Potential cosmeceutical lamellar liquid crystals containing black longan (Dimocarpus longan Lour.) seed extract for MMP-1 and hyaluronidase inhibition

Hong-in

Chaiyana

2022

Sci Rep

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The aims of this study were to evaluate the biological activities of black Dimocarpus longan Lour. seed extracts and develop a lamellar liquid crystal (LLC). Different solvents, including petroleum ether, ethyl acetate, and 95% v/v ethanol, were used in the maceration of black D. longan seeds. The inhibitory activities on matrix metalloproteinase-1 (MMP-1) and hyaluronidase were evaluated. The irritating potency of D. longan seed extracts was determined using the hen's egg chorioallantoic membrane test. The extract with the strongest anti-ageing activities and no irritant impact was examined for its chemical contents using high-performance liquid chromatography and incorporated into the LLC. Various factors affecting the LLC formulations, including surfactant types and amounts, thickening agent types and amounts, and various oil types, were investigated. The results demonstrated that the ethyl acetate extract (EtOAc) was the most potent inhibitor of MMP-1 (IC50 = 21.7 ± 5.4 µg/mL) and hyaluronidase (oleanolic acid equivalent = 0.44 ± 0.03 g per g extract). Interestingly, its MMP-1 inhibition was equivalent to that of oleanolic acid, corilagin, and gallic acid. Furthermore, its hyaluronidase inhibition was equivalent to that of gallic acid and ellagic acid. Gallic acid, which was the most abundant compound (15.6% ± 0.06% w/w) was suggested as the compound responsible for the biological activities of EtOAc extract. Considering its potential anti-skin ageing properties with no irritation of EtOAc extract, it was incorporated into the most suitable LLC, which was composed of 5% w/w Lexfeel® D5 oil, 0.5% w/w Carbopol® U21, 2% w/w Liquid Crystal Cream Maker, and 92.5% w/w DI water. The LLC containing EtOAc extract presented birefringence under a polarizing light microscope, indicating its crystallinity. The formulation had good stability after heating–cooling cycles in terms of external appearance, crystallinity, viscosity, and pH (5.5). As a result, it is recommended as a potential cosmeceutical formulation for anti-skin wrinkling. It is proposed that more research be conducted on the safety and efficacy of the treatment on human volunteers.

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Insights of lyotropic liquid crystals in topical drug delivery for targeting various skin disorders

Cited by 61 publications

References 62 publications

Insightful exploring of microRNAs in psoriasis and its targeted topical delivery

Insightful exploring of microRNAs in psoriasis and its targeted topical delivery

Vertical Alignment of Liquid Crystal on Sustainable 2,4-Di-tert-butylphenoxymethyl-Substituted Polystyrene Films

Potential cosmeceutical lamellar liquid crystals containing black longan (Dimocarpus longan Lour.) seed extract for MMP-1 and hyaluronidase inhibition

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