Insights of ion mobility spectrometry and its application on food safety and authenticity: A review

Brinke, Esra te; Arrizabalaga-Larrañaga, Ane; Blokland, Marco

doi:10.1016/j.aca.2022.340039

Cited by 17 publications

(10 citation statements)

References 219 publications

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“…Further, the sample is injected into an inductively coupled plasma source which ionizes the sample and detected by MS . Ion mobility spectrometry (IMS) is another advancement in analytical techniques that relies on ion mobility that is under the influence of velocity of ions and strength electric field. , In order to take advantage, multiple MS-based approaches can be merged and operated together, which improves the efficiency of analytical techniques. Tandem mass spectrometry (TANDEM MS), also called MS/MS, is one such approach in which samples are analyzed either by multiple mass spectrometers connected to each other or with different analyzers arranged sequentially .…”

Section: Mass Spectrometry-based Detectionmentioning

confidence: 99%

Recent Advances in the Detection of Food Toxins Using Mass Spectrometry

Ahuja,

Singh,

Paul

et al. 2023

Chem. Res. Toxicol.

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Edibles are the only source of nutrients and energy for humans. However, ingredients of edibles have undergone many physicochemical changes during preparation and storage. Aging, hydrolysis, oxidation, and rancidity are some of the major changes that not only change the native flavor, texture, and taste of food but also destroy the nutritive value and jeopardize public health. The major reasons for the production of harmful metabolites, chemicals, and toxins are poor processing, inappropriate storage, and microbial spoilage, which are lethal to consumers. In addition, the emergence of new pollutants has intensified the need for advanced and rapid food analysis techniques to detect such toxins. The issue with the detection of toxins in food samples is the nonvolatile nature and absence of detectable chromophores; hence, normal conventional techniques need additional derivatization. Mass spectrometry (MS) offers high sensitivity, selectivity, and capability to handle complex mixtures, making it an ideal analytical technique for the identification and quantification of food toxins. Recent technological advancements, such as high-resolution MS and tandem mass spectrometry (MS/MS), have significantly improved sensitivity, enabling the detection of food toxins at ultralow levels. Moreover, the emergence of ambient ionization techniques has facilitated rapid in situ analysis of samples with lower time and resources. Despite numerous advantages, the widespread adoption of MS in routine food safety monitoring faces certain challenges such as instrument cost, complexity, data analysis, and standardization of methods. Nevertheless, the continuous advancements in MS-technology and its integration with complementary techniques hold promising prospects for revolutionizing food safety monitoring. This review discusses the application of MS in detecting various food toxins including mycotoxins, marine biotoxins, and plant-derived toxins. It also explores the implementation of untargeted approaches, such as metabolomics and proteomics, for the discovery of novel and emerging food toxins, enhancing our understanding of potential hazards in the food supply chain.

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Section: Mass Spectrometry-based Detectionmentioning

confidence: 99%

Recent Advances in the Detection of Food Toxins Using Mass Spectrometry

Ahuja,

Singh,

Paul

et al. 2023

Chem. Res. Toxicol.

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“…On the other hand, low-cost stand-alone (high pressure) IMS instruments are increasingly popular due to their simple usage, high sensitivity, and fast and real-time analysis. These instruments have wide-ranging applications in the detection of volatile organic compounds (VOCs), explosives, , chemical agents, abused drugs, , food ingredients, and breath analysis. , The ionization sources of these instruments are mainly based on the atmospheric pressure chemical ionization (APCI) method, with primary ion sources such as corona discharge (CD) or 63 Ni radioactive sources…”

Section: Introductionmentioning

confidence: 99%

Formic Acid as a Dopant for Atmospheric Pressure Chemical Ionization for Negative Polarity of Ion Mobility Spectrometry and Mass Spectrometry

Ilbeigi

Valadbeigi

Moravský

et al. 2023

J. Am. Soc. Mass Spectrom.

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Formic acid (FA) is introduced as a potent dopant for atmospheric pressure chemical ionization (APCI) for ion mobility spectrometry (IMS) and mass spectrometry (MS). The mechanism of chemical ionization with the FA dopant was studied in the negative polarity using a corona discharge (CD)−IMS−MS technique in air. Standard reactant ions of the negative polarity present in air are O 2 − •(CO 2 ) n •(H 2 O) m (m = 0, 1 and n = 1, 2) clusters. Introduction of the FA dopant resulted in the production of HCOO − •FA reactant ions. The effect of the FA dopant on the APCI of different classes of compounds was investigated, including plant hormones, pesticides, acidic drugs, and explosives. FA dopant APCI resulted in deprotonation and/or adduct ion formation, [M − H] − and [M + HCOO] − , respectively. Supporting density functional theory (DFT) calculations showed that the ionization mechanism depended on the gasphase acidity of the compounds. FA dopant APCI led to the improvement of detection sensitivity, suppression of fragmentation, and changes in the ion mobilities of the analyte ions for analytes with suitable molecular structures and gas acidity.

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Section: Introductionmentioning

confidence: 99%

“…14 Recently, IMS has been reported as a rapid analytical technique for qualitative analysis of trace organics without the need for special sample preparation in many application areas: quality assurance and process monitoring in the pharmaceutical industry, 15 explosive detection, 16,17 chemical warfare agent detection, 18,19 breath analysis, 20,21 pesticide analysis, 22 environmental analysis, 23,24 and food quality and safety analysis. 25,26 Chemometric techniques have contributed signicantly to reveal and analyze the precious information content of IMS. 27 For example, Ruszkiewicz and co-workers used gas chromatography-IMS (GC-IMS) to distinguish COVID-19 patients from other epidemic patients, and principal component analysis (PCA) and orthogonal partial least squares discriminant analysis (OPLS-DA) modelling were established to improve the accuracy and reliability of the data results.…”

Section: Introductionmentioning

confidence: 99%