Insights into Transcriptional Regulation of Hepatic Glucose Production

Anyamaneeratch, Komsan; Rojvirat, Pinnara; Sukjoi, Witchuda; Jitrapakdee, Sarawut

doi:10.1016/bs.ircmb.2015.05.004

Cited by 18 publications

(22 citation statements)

References 289 publications

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“…FOXO1 control the glycometabolism through mediating the expression of metabolic enzymes which catalyze key steps [26]. Mutation or deregulation of FOXO1 can result in pathophysiological conditions, such as DM [27].…”

Section: Discussionmentioning

confidence: 99%

RETRACTED ARTICLE: Association of the polymorphisms in FOXO1 gene and diabetic nephropathy risk

Pei

Xue

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

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Purpose: This study was aimed to study the hypothesis that forkhead box O1 (FOXO1) gene rs17446614 and rs17592236 single nucleotide polymorphisms (SNPs) influenced the development of diabetic nephropathy (DN). Methods: This study included 138 DN patients and 149 healthy controls. Controls were matched with the patients in age and gender. The method of polymerase chain reaction-restriction fragment length polymorphisms (PCR-RFLP) was used to detect FOXO1 gene polymorphisms. Haploview software was conducted to analyze the linkage disequilibrium and haplotypes of FOXO1 gene polymorphisms. Relative risk of DN was expressed by odds ratios (ORs) and 95% confidence intervals (95% CIs), then the results were adjusted by clinical characteristics of the study subjects using logistic regression analysis. Subgroup analysis was performed according to gender. Results: AA genotype of rs17446614 SNPs was significantly associated with the risk of DN (P ¼ .037, adjusted OR ¼ 5.412, 95% CI ¼ 1.103-26.559), especially in female (OR ¼ 8.700, 95% CI ¼ 1.008-75.062, P ¼ .021). FOXO1 rs17446614 A allele positively associated with the development of DN (P ¼ .027, adjusted OR ¼ 1.680, 95% CI ¼ 1.060-2.662), particularly in women (OR ¼ 2.003, 95% CI ¼ 1.070-3.749, P ¼ .028). A-C haplotype formed by FOXO1 gene rs17446614 and rs17592236 SNPs was significantly associated with the increased risk of DN (P ¼ .011, OR ¼ 1.850, 95% CI ¼ 1.146-2.986). Conclusion: FOXO1 gene rs17446614 SNP, and the A-C haplotype of rs17446614 and rs17592236 polymorphisms were risk factors for the development of DN.

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Section: Discussionmentioning

confidence: 99%

RETRACTED ARTICLE: Association of the polymorphisms in FOXO1 gene and diabetic nephropathy risk

Pei

Xue

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

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“…PGC1α plays a central role in glucose and lipid metabolism regulation . The mRNA levels of PGC1α were examined.…”

Section: Resultsmentioning

confidence: 99%

“…Therefore, we have used repeated oral administration of DNLA to adult mice to investigate the effects of DNLA on the expression of genes/proteins mainly related to glucose metabolism: Peroxisome proliferator‐activated receptor‐α (PPARα) and PPAR‐γ coactivator 1α (PGC1α), glucose transports (GLUT2, GLUT4) and Forkhead transcription factor O1 (FoxO1); the expression of genes mainly related to lipid metabolism: Acox1 (acyl‐CoA oxidase 1), Cpt1a (carnitine palmitoyltransferase 1a), Srebp1 (sterol regulatory element‐binding protein 1) and Adipose triglyceride lipase (ATGL/Pnpla2); and the expression of genes/proteins mainly related to antioxidant components: MT‐1 (metallothionein‐1) and Nqo1 (NADPH quinone oxidoreductase‐1) . The results revealed that repeated DNLA administration produces beneficial effects to the liver.…”

Section: Introductionmentioning

confidence: 99%

Dendrobium nobile Lindl. alkaloids regulate metabolism gene expression in livers of mice

Wang

et al. 2017

Journal of Pharmacy and Pharmacology

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“…Indeed, the regulation of hepatic glucose production, along with glucose utilization by peripheral tissues like muscle and fat, are key regulators of systemic glycaemia [17, 26]. We first compared effects of crude preparations of control and fermented blueberry juice.…”

Section: Discussionmentioning

confidence: 99%

“…Insulin regulates hepatic glucose production and storage. It inhibits some transcription factors like the forkhead family and the Peroxisome proliferator-activated receptor-gamma coactivator-1α (PGC-1α) leading to a decrease in the activity of Glucose-6-phosphatase (G6Pase), a key enzyme implicated in hepatic glucose production [16, 17]. On the other hand, insulin signaling phosphorylates glycogen synthase kinase-3 (GSK-3) leading to the activation of glycogen synthase (GS), a key enzyme implicated in glucose storage [18].…”

Section: Introductionmentioning

confidence: 99%

Phenolic compounds isolated from fermented blueberry juice decrease hepatocellular glucose output and enhance muscle glucose uptake in cultured murine and human cells

Nachar

Eid

Vinqvist‐Tymchuk

et al. 2017

BMC Complement Altern Med

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BackgroundWe recently reported that blueberry juice fermented (FJ) with Serratia vaccinii bacterium has antidiabetic activities both in vivo and in vitro. The purpose of this project was to elucidate the effect of FJ on glucose homeostasis in liver and skeletal muscle cells and to identify active fractions/compounds responsible for this effect.MethodsFJ was fractionated using standard chromatography procedures. Hepatic (H4IIE, HepG2) and skeletal muscle cells (C2C12) were treated with maximum non-toxic concentrations of FJ, fractions and isolated compounds thereof. Glucose-6-phosphatase (G6Pase) activity was measured using glucose oxidase method. To measure glucose uptake and glycogen synthase (GS) activity, radioactive assays were used.ResultsFractionation of FJ yielded seven fractions. FJ and its phenolic fractions F2, F3-1 and F3-2 respectively inhibited G-6Pase by 31, 45, 51 and 26%; activated GS by 2.3-, 2.3-, 2.2- and 2-fold; and stimulated glucose uptake by 19, 25, 18 and 15%, as compared to DMSO vehicle control. Subfractionation of the active fractions yielded 4 compounds (catechol, chlorogenic, gallic and protocatechuic acid). Catechol, yielding the greatest bioactivity in G6Pase and glucose uptake assays, decreased G6Pase activity by 54%, increased GS by 2-fold and stimulated glucose uptake by 44% at 45.5 μM.ConclusionsThis study identifies novel potential antidiabetic compounds that can help standardize FJ.Electronic supplementary materialThe online version of this article (doi:10.1186/s12906-017-1650-2) contains supplementary material, which is available to authorized users.

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Insights into Transcriptional Regulation of Hepatic Glucose Production

Cited by 18 publications

References 289 publications

RETRACTED ARTICLE: Association of the polymorphisms in FOXO1 gene and diabetic nephropathy risk

RETRACTED ARTICLE: Association of the polymorphisms in FOXO1 gene and diabetic nephropathy risk

Dendrobium nobile Lindl. alkaloids regulate metabolism gene expression in livers of mice

Phenolic compounds isolated from fermented blueberry juice decrease hepatocellular glucose output and enhance muscle glucose uptake in cultured murine and human cells

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