“…active pharmaceutical ingredients (APIs), remains a significant challenge – which is problematic as different solid forms can exhibit significantly different physical and biological properties. 1 The challenge in controlling which form a molecule crystallises in results from the myriad of potential and poorly understood influential factors in this highly sensitive process, including concentration, temperature and its rate of change, the presence and chemistry of surfaces and co-crystallisation agents, mixing, pH, crystal seeding, solvent(s), and the intrinsic properties of the molecules themselves. While there are numerous methods for growing crystals, such as solvent evaporation and solvent layering, 2 one of the simplest is control of the thermodynamic parameter via controlled cooling of the solution.…”