2000
DOI: 10.1590/s1415-47572000000400056
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Insights into the structure of the subtelomeric chromosome segments

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Cited by 4 publications
(3 citation statements)
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“…Summarizing, even though the information presently available on the molecular analysis of the telomeric/subtelomeric DNA and associated protein complexes is considerable, a clear picture of the eukaryotic metaphase chromosome at the high level organization is still missing (Drets, 2000). The metaphase subtelomeric segments proved not to be a simple association of DNA and protein molecules linearly aligned but an intricate and compact structure with functional roles not completely understood and awaiting definition.…”
Section: Cytogenetic and Molecular Perspectivesmentioning
confidence: 99%
“…Summarizing, even though the information presently available on the molecular analysis of the telomeric/subtelomeric DNA and associated protein complexes is considerable, a clear picture of the eukaryotic metaphase chromosome at the high level organization is still missing (Drets, 2000). The metaphase subtelomeric segments proved not to be a simple association of DNA and protein molecules linearly aligned but an intricate and compact structure with functional roles not completely understood and awaiting definition.…”
Section: Cytogenetic and Molecular Perspectivesmentioning
confidence: 99%
“…The detection of similar patterns in endoreduplicated T-banded CHO chromosomes through microdensitometric scanning and computer graphic image analysis indicated that the differential distribution of HD chromatin was not due to a methodological artifact since it replicated in the same manner in the terminal region of both sister chromosomes (Drets, 2000). Moreover, T-banded segments of human and CHO chromosomes sometimes exhibited HD chromatin areas distributed like minute sister chromatid exchanges (Drets et al, 1992), what we recently called ter-SCE (Drets et al, 2006).…”
mentioning
confidence: 99%
“…Particularly, human chromosomes termini display elevated rates of mitotic recombination (Cornforth and Eberle, 2001). ter SCE as well as subtelomeric cryptic aberrations associated with severe clinical conditions could reflect a high functional activity of this chromosome region (Obe et al, 2002;Drets 2000 and2004).…”
mentioning
confidence: 99%