Insights into the roles of bacterial infection and antibiotics in Parkinson’s disease

Sheng, Shuo; Zhao, Shuo; Zhang, Feng

doi:10.3389/fcimb.2022.939085

Cited by 3 publications

(1 citation statement)

References 68 publications

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“…Squalamine does have antibiotic activity and could perhaps alter gut propulsive activity either directly by stimulating IPANs (as shown here) or by lessening of Parkinsonian intestinal dysbiosis 48 , 49 . However, antibiotics may have conflicting effects on gut motility: bacitracin, neomycin, and penicillin V increase colonic propulsion 50 , 51 while vancomycin or ampicillin decrease faecal output 52 .…”

Section: Discussionmentioning

confidence: 61%

Squalamine reverses age-associated changes of firing patterns of myenteric sensory neurons and vagal fibres

McVey Neufeld,

Mao,

West

et al. 2024

Commun Biol

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Vagus nerve signaling is a key component of the gut-brain axis and regulates diverse physiological processes that decline with age. Gut to brain vagus firing patterns are regulated by myenteric intrinsic primary afferent neuron (IPAN) to vagus neurotransmission. It remains unclear how IPANs or the afferent vagus age functionally. Here we identified a distinct ageing code in gut to brain neurotransmission defined by consistent differences in firing rates, burst durations, interburst and intraburst firing intervals of IPANs and the vagus, when comparing young and aged neurons. The aminosterol squalamine changed aged neurons firing patterns to a young phenotype. In contrast to young neurons, sertraline failed to increase firing rates in the aged vagus whereas squalamine was effective. These results may have implications for improved treatments involving pharmacological and electrical stimulation of the vagus for age-related mood and other disorders. For example, oral squalamine might be substituted for or added to sertraline for the aged.

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Section: Discussionmentioning

confidence: 61%

Squalamine reverses age-associated changes of firing patterns of myenteric sensory neurons and vagal fibres

McVey Neufeld,

Mao,

West

et al. 2024

Commun Biol

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Antimicrobial drugs for Parkinson’s disease: Existing therapeutic strategies and novel drugs exploration

Fu,

Wang,

Gao

et al. 2024

Ageing Research Reviews

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Exploring the causal relationship between B lymphocytes and Parkinson’s disease: a bidirectional, two-sample Mendelian randomization study

Song,

Qin,

Wang

et al. 2024

Sci Rep

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Parkinson’s disease (PD) is a neurodegenerative disorder with extensive involvement of motor symptoms, imposing a heavy economic burden on patients and society. B lymphocytes, a group of immune cells associated with humoral immunity, have been shown to be involved in the pathogenesis of PD. However, the causal relationship and potential pathogenic effects of B cell in PD remain unclear. Based on the three core hypotheses of the Mendelian randomization (MR) study, we explored causal associations between 190 B-cell immunological traits and 482,730 European individuals (Ncase = 33,674, Ncontrol = 449,056) from genome wide association studies by means of the two-sample bidirectional MR method. The inverse‑variance weighted method was selected as the main approach when conducting MR analysis. Finally, the results were verified by the heterogeneity and horizontal pleiotropy analyses. Five B-cell immunological phenotypes were nominally associated with PD at the significance threshold of P < 0.05. Concretely, IgD + CD38− B cell %lymphocyte (OR 1.052, 95% CI 1.001–1.106, P = 0.046), CD20 on IgD− CD24− B cell (OR 1.060, 95% CI 1.005–1.117, P = 0.032), CD38 on IgD+ CD24− B cell (OR 1.113, 95% CI 1.028–1.206, P = 0.009), and BAFF-R on CD20− B cell (OR 1.093, 95% CI 1.010–1.184, P = 0.027) were identified as risk factors for PD. Instead, CD38 on Plasma Blast-Plasma Cell (OR 0.894, 95% CI 0.802–0.996, P = 0.043) was proved to be protective. However, there is no statistically significant correlation between B cell and PD after Bonferroni correction. The results of reverse MR were negative, avoiding the reverse causal effects. Eventually, the association results were identified as stable across several sensitivity analyses. Briefly, our study might demonstrate the key factor of B cells in PD. Further studies are warranted to clarify the associations for early identification and immunotherapeutic development in PD patients.

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Insights into the roles of bacterial infection and antibiotics in Parkinson’s disease

Cited by 3 publications

References 68 publications

Squalamine reverses age-associated changes of firing patterns of myenteric sensory neurons and vagal fibres

Squalamine reverses age-associated changes of firing patterns of myenteric sensory neurons and vagal fibres

Antimicrobial drugs for Parkinson’s disease: Existing therapeutic strategies and novel drugs exploration

Exploring the causal relationship between B lymphocytes and Parkinson’s disease: a bidirectional, two-sample Mendelian randomization study

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