Insights into the roles of histone chaperones in nucleosome assembly and disassembly in virus infection

Sultana, Shirin; Zarreen, Fauzia; Chakraborty, Supriya

doi:10.1016/j.virusres.2021.198395

Cited by 10 publications

(5 citation statements)

References 189 publications

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“…In the present study, most HPV8 E7 overexpression-induced genes could be clustered into protein heterodimerization activity and DNA binding (molecular function), nucleosomes (cellular component), and nucleosome assembly (biological process). Our results support the hypothesis that viral proteins interact and manipulate not only cytoplasmic components but also nuclear factors for their survival and propagation [ 30 , 31 ]. The KEGG pathway database is a reference knowledge base that helps reconstruct molecular network systems [ 32 ].…”

Section: Discussionsupporting

confidence: 88%

Gene Expression Profile Analysis of Human Epidermal Keratinocytes Expressing Human Papillomavirus Type 8 E7

Chen

Tang

et al. 2022

Pathol. Oncol. Res.

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Background: Human papillomavirus type 8 (HPV8) has been implicated in the progress of non-melanoma skin cancers and their precursor lesions. The HPV8 E7 oncoprotein plays a key role in the tumorigenesis of HPV-associated cutaneous tumors. However, the exact role of HPV8 E7 in human epidermal carcinogenesis has not been fully elucidated.Methods: To investigate the potential carcinogenic effects of HPV8 E7 on epithelial cells, we used RNA-sequencing technology to analyze the gene expression profile of HPV8 E7-overexpressed normal human epidermal keratinocytes (NHEKs).Results: RNA-sequencing revealed 831 differentially expressed genes (DEGs) between HPV8 E7-expressing NHEKs and control cells, among which, 631 genes were significantly upregulated, and 200 were downregulated. Gene ontology annotation enrichment analysis showed that HPV8 E7 mainly affected the expression of genes associated with protein heterodimerization activity, DNA binding, nucleosomes, and nucleosome assembly. Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis revealed that overexpression of HPV8 E7 affected the expression of gene clusters associated with viral carcinogenesis and transcriptional misregulation in cancer and necroptosis signaling pathways that reportedly play crucial roles in HPV infection promotion and cancer progression. We also found the DEGs, such as HKDC1 and TNFAIP3, were associated with epigenetic modifications, immune regulation, and metabolic pathways.Conclusion: Our results demonstrate that the pro-carcinogenic effect of HPV8 expression in epithelial cells may be attributed to the regulatory effect of oncogene E7 on gene expression associated with epigenetic modifications and immune and metabolic status-associated gene expression. Although our data are based on an in vitro experiment, it provides the theoretical evidence that the development of squamous cell carcinoma can be caused by HPV.

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Section: Discussionsupporting

confidence: 88%

Gene Expression Profile Analysis of Human Epidermal Keratinocytes Expressing Human Papillomavirus Type 8 E7

Chen

Tang

et al. 2022

Pathol. Oncol. Res.

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“…It has been demonstrated that the viral histone mimicry influences host epigenetic processes and enables phase separation, thereby impacting chromatin-mediated control of gene expression. These topics have been thoroughly reviewed elsewhere [ 8 , 9 ].…”

Section: Mainmentioning

confidence: 99%

The interplay between viral molecular mimicry and host chromatin dynamics

Xiao

Wang

Shan

et al. 2023

Nucleus

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Molecular mimicry is a commonly used mechanism by viruses to manipulate host cellular machinery and coordinate their life cycles. While histone mimicry is well studied, viruses also employ other mimicry strategies to affect chromatin dynamics. However, the relationship between viral molecular mimicry and host chromatin regulation is not well understood. This review summarizes recent advances in histone mimicry and explores how viral molecular mimicry influences chromatin dynamics. We also discuss how viral proteins interact with both intact and partially unfolded nucleosomes and compare the distinct mechanisms governing chromatin tethering. Finally, we address the role of viral molecular mimicry in regulating chromatin dynamics. This review provides new insights into viral molecular mimicry and its impact on host chromatin dynamics, paving the way for the development of novel antiviral strategies.

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“…Nevertheless, their transcriptional, transpositional and retrotranspositional activity can also lead to detrimental genome instability, events of mutagenesis or cancerous transformations ( Maksakova et al, 2008 ; Robberecht et al, 2013 ). Importantly, the transposons or viruses that enter or are activated, temporarily or permanently, in the nucleus often interact with the cellular chromatin machinery and can be subjected to the process of chromatin formation ( Sultana et al, 2021 ). In the case of mammals, the major mechanism for TEs silencing is DNA methylation ( Hatanaka et al, 2015 ).…”

Section: Histone Chaperones Help In the Regulation And Silencing Of T...mentioning

confidence: 99%

Histones and their chaperones: Adaptive remodelers of an ever-changing chromatinic landscape

et al. 2022

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Chromatin maintenance and remodeling are processes that take place alongside DNA repair, replication, or transcription to ensure the survival and adaptability of a cell. The environment and the needs of the cell dictate how chromatin is remodeled; particularly where and which histones are deposited, thus changing the canonical histone array to regulate chromatin structure and gene expression. Chromatin is highly dynamic, and histone variants and their chaperones play a crucial role in maintaining the epigenetic regulation at different genomic regions. Despite the large number of histone variants reported to date, studies on their roles in physiological processes and pathologies are emerging but continue to be scarce. Here, we present recent advances in the research on histone variants and their chaperones, with a focus on their importance in molecular mechanisms such as replication, transcription, and DNA damage repair. Additionally, we discuss the emerging role they have in transposable element regulation, aging, and chromatin remodeling syndromes. Finally, we describe currently used methods and their limitations in the study of these proteins and highlight the importance of improving the experimental approaches to further understand this epigenetic machinery.

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Insights into the roles of histone chaperones in nucleosome assembly and disassembly in virus infection

Cited by 10 publications

References 189 publications

Gene Expression Profile Analysis of Human Epidermal Keratinocytes Expressing Human Papillomavirus Type 8 E7

Gene Expression Profile Analysis of Human Epidermal Keratinocytes Expressing Human Papillomavirus Type 8 E7

The interplay between viral molecular mimicry and host chromatin dynamics

Histones and their chaperones: Adaptive remodelers of an ever-changing chromatinic landscape

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