Insights into the Relationship of the Immune System with Neurodevelopmental and Psychiatric Disorders

Gottfried, Carmem; Bambini-Júnior, Victorio

doi:10.1159/000496180

Cited by 5 publications

(4 citation statements)

References 6 publications

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“…A decrease in neurogenesis markers in the offspring's hippocampus was also found, evidencing the involvement of the gut-brain axis in this context (Val-Laillet et al, 2017). Also, altered microbiota during gestation can trigger maternal immune activation, which leads to conditions in the offspring that also have anxiety as a feature, e.g., autism spectrum disorder (Careaga et al, 2017;Gottfried and Bambini-Junior, 2018). Important to mention, gut microbiota changes impact the synthesis of neurotransmitters such as serotonin, dopamine, and norepinephrine [for review see (Huang and Wu, 2021)], which also might influence the development of mood disorders.…”

Section: The Gut-brain Axis During Fetal Developmentmentioning

confidence: 88%

Mood Disorders Induced by Maternal Overnutrition: The Role of the Gut-Brain Axis on the Development of Depression and Anxiety

Jantsch

Tassinari

Giovenardi

et al. 2022

Front. Cell Dev. Biol.

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Since the first evidence suggesting that maternal nutrition can impact the development of diseases in the offspring, much has been elucidated about its effects on the offspring’s nervous system. Animal studies demonstrated that maternal obesity can predispose the offspring to greater chances of metabolic and neurodevelopmental diseases. However, the mechanisms underlying these responses are not well established. In recent years, the role of the gut-brain axis in the development of anxiety and depression in people with obesity has emerged. Studies investigating changes in the maternal microbiota during pregnancy and also in the offspring demonstrate that conditions such as maternal obesity can modulate the microbiota, leading to long-term outcomes in the offspring. Considering that maternal obesity has also been linked to the development of psychiatric conditions (anxiety and depression), the gut-brain axis is a promising target to be further explored in these neuropsychiatric contexts. In the present study, we review the relationship between maternal obesity and anxious and depressive features, exploring the gut-brain axis as a potential mechanism underlying this relationship.

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Section: The Gut-brain Axis During Fetal Developmentmentioning

confidence: 88%

Mood Disorders Induced by Maternal Overnutrition: The Role of the Gut-Brain Axis on the Development of Depression and Anxiety

Jantsch

Tassinari

Giovenardi

et al. 2022

Front. Cell Dev. Biol.

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“…Neurodevelopmental disorders such as autism and schizophrenia [45][46][47][48], as well as mood disorders [43,49,50], have been shown to exhibit a disruption of neuroimmune functions. Thus, it is particularly tempting to repurpose PPAR agonists for neurological and psychiatric disorders, as detailed in the following sections.…”

Section: The Pleiotropic Mechanism Of Action Of Ppars: Transcriptional Effects and Rapid Synaptic Regulationmentioning

confidence: 99%

Repurposing Peroxisome Proliferator-Activated Receptor Agonists in Neurological and Psychiatric Disorders

et al. 2021

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Common pathophysiological mechanisms have emerged for different neurological and neuropsychiatric conditions. In particular, mechanisms of oxidative stress, immuno-inflammation, and altered metabolic pathways converge and cause neuronal and non-neuronal maladaptative phenomena, which underlie multifaceted brain disorders. The peroxisome proliferator-activated receptors (PPARs) are nuclear receptors modulating, among others, anti-inflammatory and neuroprotective genes in diverse tissues. Both endogenous and synthetic PPAR agonists are approved treatments for metabolic and systemic disorders, such as diabetes, fatty liver disease, and dyslipidemia(s), showing high tolerability and safety profiles. Considering that some PPAR-acting drugs permeate through the blood–brain barrier, the possibility to extend their scope from the periphery to central nervous system has gained interest in recent years. Here, we review preclinical and clinical evidence that PPARs possibly exert a neuroprotective role, thereby providing a rationale for repurposing PPAR-targeting drugs to counteract several diseases affecting the central nervous system.

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“…Though much is still unknown, the role of the immune system in neurodevelopmental disorders is becoming increasingly appreciated [e.g. ( Garay and McAllister, 2010 ; Gottfried and Bambini-Junior, 2018 ; Mossink et al., 2021 ; Solek et al., 2018 ; Zengeler and Lukens, 2021 ),]. We suggest that this concept of signaling similarities be construed in the framework of the differences in perturbation levels, which depend on cell type, and timing, with chromatin structure playing a decisive role in both.…”

Section: Introductionmentioning

confidence: 99%

Neurodevelopmental disorders, immunity, and cancer are connected

2022

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Insights into the Relationship of the Immune System with Neurodevelopmental and Psychiatric Disorders

Cited by 5 publications

References 6 publications

Mood Disorders Induced by Maternal Overnutrition: The Role of the Gut-Brain Axis on the Development of Depression and Anxiety

Mood Disorders Induced by Maternal Overnutrition: The Role of the Gut-Brain Axis on the Development of Depression and Anxiety

Repurposing Peroxisome Proliferator-Activated Receptor Agonists in Neurological and Psychiatric Disorders

Neurodevelopmental disorders, immunity, and cancer are connected

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