2008
DOI: 10.1016/j.freeradbiomed.2008.05.028
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Insights into the redox biology of Trypanosoma cruzi: Trypanothione metabolism and oxidant detoxification

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Cited by 133 publications
(104 citation statements)
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“…Besides these immunological adaptations in the attempt to maximize parasitemia clearance and control the infection (36,37), the intensity of this response was not sufficient to control parasite replication and cardiac infection. On the contrary, the satisfactory effect of Bz alone against infection evolution indicated that the antiparasitic effect of Bz occurred independently of modifications in Th1 phenotype, reinforcing its direct cytotoxic action on T. cruzi (5,29,38). Our results also showed that Sur markedly increased tissue levels of IL-6, a cytokine directly implicated in acute chagasic myocarditis since it induces the expression of adhesion molecules such as intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1), prominent mediators for the migration of inflammatory cells (39,40).…”
Section: Figmentioning
confidence: 99%
“…Besides these immunological adaptations in the attempt to maximize parasitemia clearance and control the infection (36,37), the intensity of this response was not sufficient to control parasite replication and cardiac infection. On the contrary, the satisfactory effect of Bz alone against infection evolution indicated that the antiparasitic effect of Bz occurred independently of modifications in Th1 phenotype, reinforcing its direct cytotoxic action on T. cruzi (5,29,38). Our results also showed that Sur markedly increased tissue levels of IL-6, a cytokine directly implicated in acute chagasic myocarditis since it induces the expression of adhesion molecules such as intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1), prominent mediators for the migration of inflammatory cells (39,40).…”
Section: Figmentioning
confidence: 99%
“…The routes leading to oxidation and reduction of Nrx remain to be worked out. For the prototype tryparedoxin the oxidizing partner is a Prx, whereas the reduction is achieved by a typical flavin-dependent disulfide reductase mediated by the low-molecular-weight thiol trypanothione (199,349). The search for an analogous metabolic context may be helpful in finally defining the precise role of this novel redox mediator in transcriptional activation.…”
Section: Brigelius-flohé and Flohémentioning
confidence: 99%
“…Since parasites are naturally exposed to a variety of oxidative (ROS) and/or nitrosative (RNS) stresses during their life cycles, they have developed an elaborate antioxidant defense system composed of molecules and enzymes to scavenge these reactive species (14,15). These systems are primarily based on low-molecular-mass thiols, such as glutathione and trypanothione, which play central roles in the antioxidant defense mechanisms by regulating the redox homeostasis in parasites (16).…”
mentioning
confidence: 99%