Insights into the prognostic value of DJ-1 and MIB-1 in astrocytic tumors

Atti, Rasha M. Abd El; Gabal, Hoda H. Abou; Osman, Wesam M.; Saad, Amr S

doi:10.1186/1746-1596-8-126

Cited by 11 publications

(7 citation statements)

References 32 publications

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“…Glioma 34/40 (85%) [27] Medulloblastomas 32/66 (48.5%) [28] Breast cancer 22/28 (79%) [29] Non-small cell lung carcinoma 6/7 (86%) 13/18 (72.2%) [30,31] Thyroid cancer 70/74 (94.6%) [32] Prostate cancer 66/76 (86%) [33] Pancreatic neuroendocrine tumors 21/40 (52.5%) [34] Hepatocellular carcinoma Hepatitis C virus-infected hepatocellular carcinoma (HCC) 32/46 (69.6%) 30/32 (93.75%) [35] [36] Ovarian cancer 63/72 (87%) [37] Esophageal squamous cell carcinoma 11/21 (46%) [38] Cholangiocarcinoma 5/6 (83.3%) [39] Laryngeal squamous cell cancer 51/60 (85%) [40] The expression of PARK7 is associated with brain tumors. PARK7 is highly expressed in 92.8% of patients with astrocytoma, and this is directly correlated with the aggressiveness of the disease and the poor survival of patients with astrocytoma [26]. Additionally, the expression of PARK7 is upregulated in 85% of patients with glioblastoma [28] and 48.5% of patients with medulloblastoma [28].…”

Section: Role Of Park7 In Cancer Progressionmentioning

confidence: 99%

Novel Insights into PARK7 (DJ-1), a Potential Anti-Cancer Therapeutic Target, and Implications for Cancer Progression

Jin

2020

JCM

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The expression of PARK7 is upregulated in various types of cancer, suggesting its potential role as a critical regulator of the pathogenesis of cancer and in the treatment of cancer and neurodegenerative diseases, including Parkinson’s disease, Alzheimer’s disease, and Huntington disease. PARK7 activates various intracellular signaling pathways that have been implicated in the induction of tumor progression, which subsequently enhances tumor initiation, continued proliferation, metastasis, recurrence, and resistance to chemotherapy. Additionally, secreted PARK7 has been identified as a high-risk factor for the pathogenesis and survival of various cancers. This review summarizes the current understanding of the correlation between the expression of PARK7 and tumor progression.

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Section: Role Of Park7 In Cancer Progressionmentioning

confidence: 99%

Novel Insights into PARK7 (DJ-1), a Potential Anti-Cancer Therapeutic Target, and Implications for Cancer Progression

Jin

2020

JCM

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“…Many reports showed similar statistically significant differences in the Ki-67 proliferation index between high-grade and low-grade astrocytomas (44,45). The association between Ki-67 proliferation and ADC is important because it predicts the behavior of brain malignancies.…”

Section: Discussionmentioning

confidence: 75%

Apparent diffusion coefficient values and non-homogeneity of diffusion in brain tumors in diffusion-weighted MRI

et al. 2019

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Background The values that have been received from apparent diffusion coefficient (ADC) maps of diffusion-weighted magnetic resonance imaging (DW-MRI) might play a vital role in evaluating tumors and their grading scale. Purpose To investigate the predictive role of this heterogeneity in brain tumor pathologies and its correlation with Ki-67. Material and Methods A total of 124 patients with brain tumors underwent brain MRI with gadolinium injection. ADC and standard deviation of each lesion have been obtained from manual localization of the region of interest on the ADC map. A receiver operating characteristic analysis was conducted to determine the minimum cut-off values of the mean ADC and mean standard deviation of ADC maps having the highest sensitivity and specificity to differentiate high-grade and low-grade tumors. Results Mean ADC values in the region of interest were significantly lower for malignant tumors (grade IV and metastasis) than grade I brain tumors, while a higher mean standard deviation was observed. In a more detailed comparison of tumor groups, the mean standard deviation of the ADC for glioblastoma multiform was significantly higher than meningioma grade I ( P < 0.001) and metastasis was significantly higher than grade III and IV astrocytic tumors ( P = 0.004). The analysis of Ki-67 proliferation index and mean ADC values in gliomas showed a significant inverse correlation between the parameters (r = –0.0429, P < 0.001) and direct correlation between Ki-67 and mean standard deviation of the ADC (r = 0.551, P < 0.001). As an index for the ADC to differentiate high-grade and low-grade tumors, the cut-off values of 1.40*10−3 mm2/s for mean ADC and 45*10−3 mm2/s for mean standard deviation have the highest combination of sensitivity, specificity, and area under the curve. Conclusion The mean value and standard deviation of the ADC could be considered for differentiating between low-grade and high-grade brain tumors, as two available non-invasive methods.

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“…PARK7 expression appears to be differently altered according to diseases conditions, and/or cell types (37,38). For instance, PARK7 is highly expressed in lipopolysaccharides-induced acute lung injury (39), while decreased in heavy smoking-induced lung disease (40).…”

Section: Discussionmentioning

confidence: 99%

PARK7 Protects Against Chronic Kidney Injury and Renal Fibrosis by Inducing SOD2 to Reduce Oxidative Stress

Yin

Liu

et al. 2021

Front. Immunol.

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Renal fibrosis is the final common pathway to chronic kidney diseases regardless of etiology. Parkinson disease protein 7 (PARK7) is a multifunctional protein involved in various cellular processes, but its pathophysiological role in kidneys remain largely unknown. Here, we have determined the role of PARK7 in renal fibrosis and have further elucidated the underlying mechanisms by using the in vivo mouse model of unilateral ureteric obstruction (UUO) and the in vitro model of transforming growth factor-b (TGFB1) treatment of cultured kidney proximal tubular cells. PARK7 decreased markedly in atrophic kidney tubules in UUO mice, and Park7 deficiency aggravated UUO-induced renal fibrosis, tubular cell apoptosis, ROS production and inflammation. In vitro, TGFB1 treatment induced fibrotic changes in renal tubular cells, which was accompanied by alterations of PARK7. Park7 knockdown exacerbated TGFB1-induced fibrotic changes, cell apoptosis and ROS production, whereas Park7 overexpression or treatment with ND-13 (a PARK7-derived peptide) attenuated these TGFB1-induced changes. Mechanistically, PARK7 translocated into the nucleus of renal tubular cells following TGFB1 treatment or UUO, where it induced the expression of SOD2, an antioxidant enzyme. Taken together, these results indicate that PARK7 protects against chronic kidney injury and renal fibrosis by inducing SOD2 to reduce oxidative stress in tubular cells.

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Insights into the prognostic value of DJ-1 and MIB-1 in astrocytic tumors

Cited by 11 publications

References 32 publications

Novel Insights into PARK7 (DJ-1), a Potential Anti-Cancer Therapeutic Target, and Implications for Cancer Progression

Novel Insights into PARK7 (DJ-1), a Potential Anti-Cancer Therapeutic Target, and Implications for Cancer Progression

Apparent diffusion coefficient values and non-homogeneity of diffusion in brain tumors in diffusion-weighted MRI

PARK7 Protects Against Chronic Kidney Injury and Renal Fibrosis by Inducing SOD2 to Reduce Oxidative Stress

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