Insights into the production and characterization of electrospun fibers from regenerated silk fibroin

Solanas, Concepción; Herrero, Sara; Dasari, Aravind; Plaza, Gustavo R.; LLorca, J.; Pérez‐Rigueiro, José; Calafat, Manuel Elices; Guinea, Gustavo V.

doi:10.1016/j.eurpolymj.2014.08.030

Cited by 10 publications

(9 citation statements)

References 78 publications

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“…It has been approved that promoting β-sheet crystallization reduces the hydrodynamic radius of the protein chains and increases intra-molecular hydrogen bonding between them. 29,30 For ratio of 1:1, the conformational change from random coil to β-sheet structure resulted in shrinking of nanoparticles and reduction in their size.…”

Section: Resultsmentioning

confidence: 99%

Preparation and Characterization of Silk Fibroin Nanoparticles as a Potential Drug Delivery System for 5-Fluorouracil

et al. 2019

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Purpose: The aim of this study is to prepare 5-fluorouracil (5-FU) loaded silk fibroin nanoparticles (SFNPs) and to achieve a controlled release delivery system with the high loading capacity. Methods: SFNPs with 1:1, 1:3, and 1:10 ratios of 5-FU to silk fibroin were prepared. SFNPs were characterized by Fourier-transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD) analysis, Scanning electron microscope (SEM), and Transmission electron microscope (TEM). Loading efficiency, in vitro release, and cell viability were studied for optimal SFNPs. Results: The ratio of 1:1 was optimal formulation with the size and polydispersity index (PDI) of 221.03 nm and 0.093 before freeze drying, and 286.7 nm and 0.154 after freeze drying by lactose, respectively. The loading efficiency and loading content of this ratio were 52.32% and 34.35%, respectively. FT-IR and XRD analysis indicated the conformational change (from random coil to β-sheet) in the structure of nanoparticles by increasing amount of the drug, which caused the smaller size, the higher loading efficiency, and the slower release pattern. The drugloaded nanoparticles reached to the half maximal inhibitory concentration (IC50) that were comparable with free drug on MCF7 (human breast cancer) cell line. Conclusion: This study was planned to achieve a promising controlled release drug delivery system for carrying 5-FU, as a potent anticancer drug. SFNPs were found proper candidates for delivery of a hydrophilic drug such as 5-FU.

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Section: Resultsmentioning

confidence: 99%

Preparation and Characterization of Silk Fibroin Nanoparticles as a Potential Drug Delivery System for 5-Fluorouracil

et al. 2019

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“…30 The electrospinning of regenerated silk fibers allows the efficient spinning of non-wovens and mats, although the tensile properties of the individual electrospun fibers tend to be poorer than those of their wet spun counterparts. [31][32][33][34] In addition to the conventional wet spinning and electrospinning processes, an enhanced understanding of the principles on which the natural spinning process is based has led to the development of a number of biomimetic techniques, many of which rely on the dependence of self-assembly of the silk proteins on the pH variations of the surrounding medium. [35][36][37][38][39] These techniques have allowed reaching values of tensile strength as high as s u $ 600 MPa 35 and values of strain at breaking as high as 40%.…”

mentioning

confidence: 99%

Production of regenerated silkworm silk fibers from aqueous dopes through straining flow spinning

Madurga

Gañán‐Calvo

Mariscal

et al. 2019

Textile Research Journal

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The possibility of spinning regenerated silkworm ( Bombyx mori) fibers from a range of aqueous dopes by using a biomimetic approach based on straining flow spinning is explored in this work. It is found that spinning conditions can be established that allow fibers to be produced from environmentally friendly dopes with fibroin concentrations even one order of magnitude lower than that of the natural system. However, it is also found that the spinning process is favored and that the mechanical properties of the fibers are improved when dopes with higher fibroin concentration are employed. Since highly concentrated fibroin solutions in water are unstable, a stabilizing agent is required in order to obtain a spinnable dope at such large protein concentrations. CaCl2 is found to be an adequate stabilizing agent compatible with the straining flow spinning process. The optimization of the spinning parameters leads to the production of high-performance fibers with a work to fracture comparable to that of the natural material.

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“…Meanwhile, the breathability of R/Z-PET/ nano-PLA mat decreases from 98.95 to 39.17 mm s −1 . The increasing basis weight of the nano-PLA membrane enhanced the entanglement percentage between fibers in per unit area [40,41]. At the same basis weight, the average pore size of R/Z-PET/nano-PLA mat decreases comparing with that of the nano-PLA membrane, and this is the result of modification of R/Z-PET web on the pore structure of mat.…”

Section: Filtration Properties Of R/z-pet/nano-pla Mats With Differenmentioning

confidence: 93%

High filtration efficiency fluffy material: nano-fiber constructing gradient structure on recycled curved PET micro-fibers web

Deng

Zhang²,

Zhang

et al. 2019

SN Appl. Sci.

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High efficiency filtration materials focus on electreted melt-blown polypropylene nonwoven and nano-scale fibers membrane in industry. However, the charge decay and the balance of efficiency and resistance are still facing challenges on research and practical applications. In this research, combined with traditional electrospinning and carding process, a simple and new fluffy gradient filtration material was designed by constructing nano-scale poly(lactic acid) (nano-PLA) fiber membranes on recycled three-dimensional curved poly(ethylene terephthalate) (R-PET) micro-fibers webs. Influences of basis weights of nano-PLA membranes and curved types of R-PET fibers on the filtration performance and the dust-holding capacity of R-PET/nano-PLA mats were investigated. Besides, the filtration mechanism of R-PET/nano-PLA mats was systemically studied. Results show that R-PET with zigzag curve (R/Z-PET) possesses the highest filtration efficiency of 99.992% comparing with 99.517% of linear R-PET, the pressure drop fall to 201.11 Pa, and a quality factor level up from 0.024 to 0.047 Pa −1. The pressure raising rate of the R/Z-PET/nano-PLA mat is the slowest. R/Z-PET fibers with a folding angle of 90° benefit to decrease the friction between fiber and particles when the location angle of zigzag fiber is 45° along the airflow direction, which decrease the pressure drop at high filtration efficiency. Surface residual charges contribute some effect on the overall filtration performance of the R-PET/nano-PLA mat. A new way of simple curved micro-PET fiber combining with nano-scale fibers provides an industrial available path to mass production of high efficiency filtration material serving for air pollution control without electret process.

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Insights into the production and characterization of electrospun fibers from regenerated silk fibroin

Cited by 10 publications

References 78 publications

Preparation and Characterization of Silk Fibroin Nanoparticles as a Potential Drug Delivery System for 5-Fluorouracil

Preparation and Characterization of Silk Fibroin Nanoparticles as a Potential Drug Delivery System for 5-Fluorouracil

Production of regenerated silkworm silk fibers from aqueous dopes through straining flow spinning

High filtration efficiency fluffy material: nano-fiber constructing gradient structure on recycled curved PET micro-fibers web

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