Insights into the processability and performance of adhesive blends of inhalable jet-milled and spray dried salbutamol sulphate at different drug loads

Pinto, Joana T.; Stranzinger, Sandra; Kruschitz, Andreas; Faulhammer, Eva; Stegemann, Sven; Roblegg, Eva; Paudel, Amrit

doi:10.1016/j.jddst.2018.10.014

Cited by 10 publications

(6 citation statements)

References 47 publications

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“…39 A similar WAXS pattern was also observed for the spray-dried sample used as a reference for the predominantly amorphous state of SS. 46 Quantification of the AmC in the samples via WAXS is reported in Table 4 and overall found to be consistent with the ATR-FTIR method used for quantification.…”

Section: Resultssupporting

confidence: 93%

“…The disappearance of Bragg peaks and incoherent scattering that results in an amorphous halo indicates significant disorder in the sample ball-milled for 120 min . A similar WAXS pattern was also observed for the spray-dried sample used as a reference for the predominantly amorphous state of SS . Quantification of the AmC in the samples via WAXS is reported in Table and overall found to be consistent with the ATR-FTIR method used for quantification.…”

Section: Resultsmentioning

confidence: 99%

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Insights into the Impact of Nanostructural Properties on Powder Tribocharging: The Case of Milled Salbutamol Sulfate

et al. 2022

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The impact of the crystallinity of organic solid materials on their tribocharging propensity is well reported. However, no unequivocal explanation about the potential underlying mechanism(s) could be found so far in the literature. This study reports the effect that different degrees of crystalline disorder has on the tribocharging propensity of a small molecular organic material, salbutamol sulfate (SS). Ball-milling was used to induce structural transformations in the crystalline structure of SS. Particles with different nanostructures were produced and analyzed for their solid-state, particle properties, and tribocharging. It was found that differences in the amorphous content among the processed particles and related moisture levels had an impact on powder tribocharging. A correlation between the latter and the nanostructural properties of the particles was also established. The presence of interfaces between nanodomains of different densities and shorter average lengths within the phases seems to lead to a mitigation of charge. This suggests that undetected, subtle nanostructural differences of materials can affect powder handling and processability by altering their tribocharging. The present findings demonstrate the nanostructural implications of powder triboelectrification, which can help toward the rational design of a wide variety of organic solids.

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Section: Resultssupporting

confidence: 93%

Section: Resultsmentioning

confidence: 99%

Insights into the Impact of Nanostructural Properties on Powder Tribocharging: The Case of Milled Salbutamol Sulfate

et al. 2022

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“…From our previous works, we know that SBS SD is more cohesive than SBS JM. The latter, in turn, showed a higher tendency to attach to the surface of lactose monohydrate and D-mannitol ( 13 , 40 ). As such, SBS JM surface physicochemical interactions with MAN will be more favourable, promoting the adherence of fine particles to the coarse MAN carrier surfaces and contacts will be dominated by the fine particles and the blends will charge to a lower extent (fines showed to charge to a lower extent that the coarse material).…”

Section: Discussionmentioning

confidence: 99%

Tribo-Charging Behaviour of Inhalable Mannitol Blends with Salbutamol Sulphate

et al. 2019

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Purpose The performance of carrier-based dry powder inhaler (DPI) formulations can be critically impacted by interfacial interactions driven by tribo-electrification. Therefore, the aim of the present work was to understand how distinct API particle characteristics affect the charging behaviour of blends intended for DPI delivery. Methods Salbutamol sulphate (SBS) particles engineered via spray-drying and jet milling were used as model APIs. D-mannitol was selected as a model carrier. The materials were characterized concerning their different particle properties and their charge was analysed alone and in blends before and after flow over a stainless-steel pipe. Results The spray-dried SBS (amorphous and spherical) charged positively and to a higher extent than jet milled SBS (crystalline and acicular) that charged negatively and to a lower extent. D-mannitol charged positively and to a higher extent than the APIs. All drug-excipient blends charged negatively and differences were found between the spray-dried and jet milled SBS blends at 2% and 5% drug loads. Conclusions It was demonstrated how distinct solid-states, particle shape, size and morphology as well as different water contents of the different materials can affect tribo-charging. For their binary blends, the amount and nature of fines seem to govern inter-particle contacts critically impacting charge evolution. Electronic supplementary material The online version of this article (10.1007/s11095-019-2612-9) contains supplementary material, which is available to authorized users.

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“…Salbutamol had among the three APIs the lowest upper concentration level for S1, generating the lowest SPV ( Table 4 ), and the lowest concentration at which self-agglomerates were formed (S3). It is previously reported that nearly spherical spray-dried salbutamol had a higher tendency to pack into open pores of a carrier ( Mönckedieck et al 2017 ) and a lower tendency to attach to the outer surface of the carriers ( Pinto et al 2018 ) than more irregular milled salbutamol particles. Thus, the low amount of particles adsorbed into open surface pores of the carrier may, at least partly, be explained by the needle-like shape of the salbutamol particles making packing into open pores of the carrier difficult.…”

Section: Discussionmentioning

confidence: 99%

On the relationship between blend state and dispersibility of adhesive mixtures containing active pharmaceutical ingredients

Rudén

Frenning

Bramer

et al. 2021

International Journal of Pharmaceutics: X

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Insights into the processability and performance of adhesive blends of inhalable jet-milled and spray dried salbutamol sulphate at different drug loads

Cited by 10 publications

References 47 publications

Insights into the Impact of Nanostructural Properties on Powder Tribocharging: The Case of Milled Salbutamol Sulfate

Insights into the Impact of Nanostructural Properties on Powder Tribocharging: The Case of Milled Salbutamol Sulfate

Tribo-Charging Behaviour of Inhalable Mannitol Blends with Salbutamol Sulphate

On the relationship between blend state and dispersibility of adhesive mixtures containing active pharmaceutical ingredients

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