Insights into the potential carcinogenicity of micro- and nano-plastics

Journey of micronanoplastics with blood components

“…177 Researchers have revealed that exposure to polystyrene microplastics signicantly harmed human white blood cells, peripheral blood mononuclear cells, and human hematopoietic cells, resulting in cytotoxicity, oxidative stress, immunomodulatory and inammatory reactions, and further genotoxic potential, leading to a considerable increase in the levels of DNA damage and mutations. 45,[178][179][180] Understanding how nanoparticles interact with blood components is a crucial rst step in evaluating their true hazard potential.…”

Elucidating the effects of naturally weathered aged-polypropylene microplastics and newly procured polypropylene microplastics on raw 264.7 macrophages

“…31 These interactions may result in inflammation or autoimmune interference, or they may increase the host's susceptibility to infection and cancer. 32 Moreover, microplastics (MPs) have consistently demonstrated their ability to move mucosa tissues (intestinal and bronchial epithelial barriers) to the blood and lymphatic circulation. 33 However, PP microparticles have been used in biomedicine as a paradigm in pharmaceutical research, which has added more knowledge about their related biological effects.…”

Role of Microplastics in Chronic Rhinosinusitis Without Nasal Polyps

“…15 The potential of micro-nanoplastics to induce genotoxicity has been recognized as a strong predictor of carcinogenicity. 16 It has been reported that a relationship between the ability of MPs to accumulate in cells and tissues and carcinogenic potential can be demonstrated. 16 Studies on MPs are generally related to the gastrointestinal tract and lower respiratory tract.…”

“…16 It has been reported that a relationship between the ability of MPs to accumulate in cells and tissues and carcinogenic potential can be demonstrated. 16 Studies on MPs are generally related to the gastrointestinal tract and lower respiratory tract. Considering that we have been exposed to MPs for a long time, it makes sense that MPs may be involved in the pathophysiology of diseases such as chronic sinusitis.…”

“…Micro‐nanoplastics have been shown to induce mechanisms necessary for cancer development 15 . The potential of micro‐nanoplastics to induce genotoxicity has been recognized as a strong predictor of carcinogenicity 16 . It has been reported that a relationship between the ability of MPs to accumulate in cells and tissues and carcinogenic potential can be demonstrated 16 …”