Insights Into the Pathophysiology of Cellulite: A Review

Bass, Lawrence S.; Kaminer, Michael S.

doi:10.1097/dss.0000000000002388

Cited by 47 publications

(110 citation statements)

References 65 publications

Supporting

Mentioning

106

Contrasting

Unclassified

Order By: Relevance

“…Equally important as the disruption of fibrous septae is the mechanical action of the rapid acoustic pulses on the dermal extracellular matrix that leads to a number of biological effects including neocollagenesis and angiogenesis. The direct and indirect stimulation of the dermal extracellular matrix and fibroblasts results in the remodeling of the dermis 13,14 . Figure 9 provides a series of histological images of porcine subcutaneous tissue treated with acoustic subcision demonstrating increased neocollagenesis.…”

Section: Discussionmentioning

confidence: 99%

Improvement in the appearance of cellulite and skin laxity resulting from a single treatment with acoustic subcision: Findings from a multicenter pivotal clinical trial

Tanzi¹,

Capelli

Robertson

et al. 2021

Lasers Surg Med

Self Cite

View full text Add to dashboard Cite

Introduction and Objectives: Surface depressions and skin laxity together play a role in the appearance of cellulite. Cellulite depressions can be improved through disruption of the subcutaneous fibrous structures. Some currently utilized approaches accomplish this through invasive techniques requiring local anesthesia and potential down time. Skin laxity can exacerbate the appearance of cellulite, however current invasive approaches do little to improve skin laxity. The objective of this study was to evaluate a noninvasive approach to improving both cellulite depressions and skin laxity through the use of rapid acoustic pulses (acoustic subcision). Safety, efficacy, tolerability, and participant satisfaction results were measured. Methods: Women (n = 56) with moderate to severe cellulite were treated in a single acoustic subcision treatment session without anesthesia. Posttreatment adverse events (AEs) and tolerability were recorded. At 12-weeks cellulite outcomes were assessed using a 6-point simplified Cellulite Severity Scale (CSS), Global Aesthetic Improvement Scale (GAIS), and a participant satisfaction questionnaire. Additionally, laxity improvement was measured using a 4-point Laxity Score (LS) and GAIS. Results: Improvement in cellulite appearance measured at 12-weeks showed that participants (n = 56) had a mean CSS reduction of 1.01 (a 29.5% reduction from baseline). The posttreatment photograph was correctly identified by blinded independent reviewers from randomized pairs of pre/posttreatment photographs for 96.4% of participants. Cellulite was graded as improved, much improved or very much improved using the GAIS at 90.9% of treated locations. Finally, 92.9% of participants reported positive satisfaction responses. Scoring for improvement in skin laxity appearance at 12-weeks showed a mean LS reduction of 0.57 (a 27.9% reduction from baseline). GAIS for laxity was graded as improved, much improved or very much improved in 67.3% of treated areas. No unexpected or serious AEs were noted at treatment or follow-up. Overall average pain score during treatment was 2.4 (0-10 pain scale) and 0.3 immediately posttreatment. Conclusion: A single noninvasive acoustic subcision session can safely provide meaningful improvement in the appearance of cellulite in terms of depressions, as well as skin laxity, with minimal treatment pain and no posttreatment down time. Further improvement in appearance is expected with multiple treatments over time. Additional trials to verify this are planned.

show abstract

Section: Discussionmentioning

confidence: 99%

Improvement in the appearance of cellulite and skin laxity resulting from a single treatment with acoustic subcision: Findings from a multicenter pivotal clinical trial

Tanzi¹,

Capelli

Robertson

et al. 2021

Lasers Surg Med

Self Cite

View full text Add to dashboard Cite

show abstract

“…Although cellulite often affects healthy normal-weighted patients, obesity can trigger its composition. In some patients, loss of weight may worsen the grade of cellulite [ 21 , 22 ].…”

Section: Discussionmentioning

confidence: 99%

“…A stabilized retinol formulation (Retinol ActifPur®, Roche) was applied twice daily for 4 weeks on the affected area for both groups [ 21 ]. The amount to be applied was demonstrated by creating a layer of about 0.1 mm to coat the affected area, and gentle massage was applied for equal distribution of the topical treatment on the whole area [ 22 ].…”

Section: Methodsmentioning

confidence: 99%

Comparison of Extracorporeal Shock Wave Therapy versus Manual Lymphatic Drainage on Cellulite after Liposuction: A Randomized Clinical Trial

Allam

Elshorbagy

Eid

et al. 2021

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Introduction. Cellulite is associated with variations in the skin appearance with cottage cheese, mattress-like, or orange peel. The most common areas for these lesions are the posterior or upper thighs and buttocks and mainly affect females after puberty. The objective of the study was to determine whether extracorporeal shock wave therapy (ESWT) or manual lymphatic drainage (MLD) is more effective for the reduction of the grade of cellulite after liposuction. Methods. This study is a single-blinded randomized controlled clinical trial. Thirty females with grade 3 cellulite were randomly distributed into two groups equal in number (n = 15), group A was equipped to ESWT and group B was equipped to MLD. The cellulite grading scale was used to assess cellulite grade, and the skinfold caliper was used to assess the thickness of subcutaneous fat. The assessment was carried out before and four weeks after starting the treatment. Both groups received topical retinol twice daily for four weeks; in addition, group A received ESWT, while group B received MLD, two times/week for 4 weeks. Results. The mean values of the skinfold caliper in group A decreased by 24.4% and in group B by 15.38% with a significant difference between the two groups p < 0.001 . Also, the mean values of the cellulite grading scale decreased significantly after treatment in group A compared with the mean values of group B p < 0.001 . Conclusions. There was more reduction in the grade of cellulite and thickness of subcutaneous fat in the ESWT group than the MLD group after liposuction.

show abstract

“…A HLDG atinge até 90% das mulheres, praticamente em todas as fases do ciclo de vida, iniciando após a puberdade (ATAMOROS et al, 2018). Em homens saudáveis, a celulite é rara, mas pode ocorrer devido a condições médicas que resultam em deficiência de hormônios andrógenos ou requerem terapia com estrógenos (BASS; KAMINER, 2020). Embora não exista morbidade ou mortalidade associada à celulite, ou seja, não se trata de doença, ela permanece como preocupação estética frequentemente importante.…”

Section: Introductionunclassified

Celulite: uma breve revisão / Cellulite: a brief review

Hernandes¹,

Santos²,

Vila³

2022

BJDV

View full text Add to dashboard Cite

A hidrolipodistrofia ginoide (HLDG), conhecida como “celulite”, envolve alteração do relevo cutâneo e ocorre em 90% da população feminina. Dependendo da intensidade do quadro estabelecido, essa dermatose inestética pode ser responsável por importantes distúrbios psicossociais. As opções terapêuticas disponíveis para a HLDG são numerosas e complementares, podendo variar de modalidades convencionais (aplicações tópicas e massagens, luz intensa pulsada, ondas acústicas e radiofrequência) até abordagens minimamente invasivas, como subcisão, terapia a laser e injeções. Contudo, não se verificam estudos capazes de indicar, definitivamente, quais são os tratamentos melhores e mais eficazes.

show abstract

Insights Into the Pathophysiology of Cellulite: A Review

Abstract: Supplemental Digital Content is Available in the Text.

Cited by 47 publications

References 65 publications

Improvement in the appearance of cellulite and skin laxity resulting from a single treatment with acoustic subcision: Findings from a multicenter pivotal clinical trial

Improvement in the appearance of cellulite and skin laxity resulting from a single treatment with acoustic subcision: Findings from a multicenter pivotal clinical trial

Comparison of Extracorporeal Shock Wave Therapy versus Manual Lymphatic Drainage on Cellulite after Liposuction: A Randomized Clinical Trial

Celulite: uma breve revisão / Cellulite: a brief review

Contact Info

Product

Resources

About