Insights into the Multifaceted Roles of Thioredoxin-1 System: Exploring Knockout Murine Models
Tetiana Shcholok,
Eftekhar Eftekharpour
Abstract:Redox balance is increasingly identified as a major player in cellular signaling. A fundamentally simple reaction of oxidation and reduction of cysteine residues in cellular proteins is the central concept in this complex regulatory mode of protein function. Oxidation of key cysteine residues occurs at the physiological levels of reactive oxygen species (ROS), but they are reduced by a supply of thiol antioxidant molecules including glutathione, glutaredoxin, and thioredoxin. While these molecules show complex… Show more
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