Insights into the molecular pathogenesis of follicular lymphoma arising from analysis of geographic variation

Biagi, James; Seymour, John F.

doi:10.1182/blood.v99.12.4265

Cited by 125 publications

(117 citation statements)

References 114 publications

(101 reference statements)

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“…Significant differences in molecular abnormalities are common in studies conducted across different continents, even in the same cancer type. 23,24 In this study, we had examined cases from United States and Chile, while Tannapfel's work was based solely on German cases. Secondly, there could be major epidemiological differences between the two sets.…”

Section: Discussionmentioning

confidence: 99%

The V599E BRAF mutation is uncommon in biliary tract cancers

et al. 2004

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Activating point mutations of the BRAF oncogene have been identified in several solid tumors, most commonly in cutaneous melanomas and papillary carcinomas of the thyroid. A specific point mutation-V599E-accounts for the overwhelming majority of these mutational events. We explored the frequency of the V599E BRAF mutation in biliary tract cancers. In all, 62 archival biliary tract cancers, including 15 gallbladder cancers, 15 extrahepatic, and 10 intrahepatic cholangiocarcinomas from the United States, and 22 gallbladder carcinomas from Chile were analyzed for the V599E mutation of the BRAF gene using three distinct methods: direct sequencing, a primer extension method (Mutector s assay), and the highly sensitive quantitative Gap Ligase Chain Reaction. The common V599E mutation was not identified in any of the 62 biliary cancer samples using these three methods of detection. The V599E somatic mutation of the BRAF gene is absent in biliary tract cancers, at least in the two geographic populations (United States and Chile) examined. Activation of the RAS/ RAF/MAP kinase pathway in biliary tract cancers is likely to be secondary to oncogenic RAS mutations, or due to mutations of the BRAF gene at nucleotide positions not explored in the current study.

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Section: Discussionmentioning

confidence: 99%

The V599E BRAF mutation is uncommon in biliary tract cancers

et al. 2004

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“…We searched the database of the Department of Hematopathology at The University of Texas MD Anderson Cancer Center, from 1 January 2000 to 30 June 2014, for cases of follicular lymphoma that were positive for CD5 as shown by flow cytometry immunophenotypic analysis or immunohistochemistry. A group of 99 patients with CD5-negative follicular lymphoma matched for age, gender, and stage were selected as a comparison group.…”

Section: Case Selectionmentioning

confidence: 99%

CD5-positive follicular lymphoma: clinicopathologic correlations and outcome in 88 cases

Liu

Zuo

et al. 2015

Modern Pathology

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Follicular lymphoma is a low-grade B-cell lymphoma of germinal center B-cell origin that typically lacks CD5 expression. We describe the clinicopathologic features of 88 cases of CD5+ follicular lymphoma (53 men, 35 women; median age, 60 years; range, 31-86). Follicular lymphoma was diagnosed initially in lymph nodes in 66 and extranodal sites in 22 patients. Eighty-one patients had lymphadenopathy, 66 had more than one involved site, 46 had bone marrow involvement, and 7 had splenomegaly. Staging information was available for 84 patients: 52 stage IV, 18 stage III, 12 stage II, and 2 stage I. Sixty-one cases were grade 1 or 2 and 27 were grade 3. The median proliferation index (Ki-67) was 30%. CD5 expression was detected by flow cytometry in 69, immunohistochemistry in 8, and both methods in 11 cases. The presence of t(14;18)(q32;q21)/IGH-BCL2 or other BCL2 translocation was detected in 28/44 (64%) cases. A total of 38 (43%) patients also had diffuse large B-cell lymphoma, concurrent with (n = 20), subsequent to (n = 13), or developing before CD5+ follicular lymphoma (n = 5). All patients received chemotherapy; 12 also received stem-cell transplantation. With a median follow-up of 55 months (range, 0.5-207), 15 patients died, 46 were alive with disease, and 20 were in clinical remission. Compared with a matched group of patients with CD5− follicular lymphoma, patients with CD5+ follicular lymphoma more commonly had an International Prognostic Index 42 (35/80 vs 10/99, Po0.001), more often developed diffuse large B-cell lymphoma (38/88 vs 17/99; Po 0.001), and had a shorter median progression-free survival (44 vs 89 months, P = 0.0042). Higher Ki-67 and International Prognostic Index were identified as poor prognostic factors in both the groups. We conclude that CD5 expression in follicular lymphoma is associated with a higher International Prognostic Index, higher rate of transformation to diffuse large B-cell lymphoma, and shorter progression-free survival.

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“…The reported distribution of NHL subtypes in India is different with those from the rest of the world [2]. In a study from India by Naresh et al [3] which incorporated immunophenotypic studies to investigate the distribution of NHL subtypes, FL was found to constitute about 12.6 % of all NHL.…”

Section: Discussionmentioning

confidence: 99%

“…Follicular Lymphoma (FL) is one of the most common B-cell non hodgkin lymphomas (NHL) accounting for 20-40 % in the western population [1,2]. The incidence is stated to be much lower in the Asian countries and about 12 % in the Indian population [3].…”

Section: Introductionmentioning

confidence: 99%

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Nodal Follicular Lymphomas: A Clinicopathological Study from a Tertiary Care Centre in South India

Supari

Ananthamurthy

2015

Indian J Hematol Blood Transfus

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The aim of this study was to assess the distribution of nodal follicular lymphomas (FL) among various subtypes of non-Hodgkin lymphoma and to study their clinico-pathological features. Clinical details, histomorphology including grading & patterns and immunoprofile of 44 cases were studied. Majority of the cases were grade 1 (61 %) FL. BCL2 positivity was higher in low grade FLs (97 %). An associated diffuse large B cell lymphoma component was seen in 18 % and was present only in conjunction with grade 3 FL. Majority of our patients (76 %) had a high FLIPI score and belonged to the high risk group. Our study showed that the incidence of FLs is much lower in the Indian population (14.5 %) when compared to western studies and majority were of low grade. Although there was complete initial response to treatment, relapse was common and was much higher in low grade FLs with diffuse areas on histology, Ann Arbor stage III/IV and FLIPI scores of 3-5.

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Insights into the molecular pathogenesis of follicular lymphoma arising from analysis of geographic variation

Cited by 125 publications

References 114 publications

The V599E BRAF mutation is uncommon in biliary tract cancers

The V599E BRAF mutation is uncommon in biliary tract cancers

CD5-positive follicular lymphoma: clinicopathologic correlations and outcome in 88 cases

Nodal Follicular Lymphomas: A Clinicopathological Study from a Tertiary Care Centre in South India

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