Insights into the molecular basis of reduced vancomycin susceptibility among three prominent
Staphylococcus aureus
clonal complexes
Natalia Malachowa,
Daniel E. Sturdevant,
Adeline R. Porter
et al.
Abstract:Staphylococcus aureus
is a leading cause of healthcare-associated infections globally. Vancomycin-resistant
S. aureus
(VRSA), those with high-level resistance [minimum inhibitory concentration (MIC) of 16–32 µg/mL vancomycin], are uncommon, whereas vancomycin-intermediate
S. aureus
(VISA; MIC of 4–8 µg/mL), are isolated more frequently and develop during long-term and/or repeated use of the antibiotic. VISA can be difficult to eradicate and … Show more
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