Insights into the mechanisms underlying the antitumor activity of an oxidovanadium(IV) compound with the antioxidant naringenin. Albumin binding studies

Islas, María Soledad; Naso, Luciana G.; Lezama, Luís; Valcárcel, María; Salado, Clarisa; Roura-Ferrer, Meritxell; Ferrer, Evelina G.; Williams, Patricia Ana María

doi:10.1016/j.jinorgbio.2015.04.011

Cited by 38 publications

(26 citation statements)

References 62 publications

(90 reference statements)

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“…Some vanadium compounds, such as vanadylsulphate, sodium vanadate and peroxidovanadates have shown antitumor activity in experimental models in vitro and in vivo [177][178][179][180][181][182]. Vanadocene dichloride [183], vanadium(III)-L-cysteine complexes [47], complexes Metvan [V IV O(SO 4 )(4,7-Mephen) 2 ] [2, 24,184], vanadium complexes with flavonoids and other polyphenols [185], semicarbazone derivatives [186], vanadium-Schiff base complexes [179,187], have demonstrated antitumor properties, which have been studied in different types of cell lines, inhibiting cell proliferation throughout the range of concentrations studied. The chemical structure of different vanadium compounds with antitumor activity is shown in Fig.…”

Section: Bioinorganic Implication and Application Of Vanadium Complexesmentioning

confidence: 99%

“…It is widely known that these types of natural products have antioxidant, cytotoxic and chemosensitizing properties [207,208]. Among the most outstanding complexes are: those of naringenin [185], morin [209] chrysin and silibinin [210]. In the late of 1990s, it was shown that some vanadium compounds also had chemopreventive effects, since chelating compounds may have a significant effect on improving the antioxidant and antitumor properties of flavonoids [2].…”

Section: Bioinorganic Implication and Application Of Vanadium Complexesmentioning

confidence: 99%

See 1 more Smart Citation

Vanadium: History, chemistry, interactions with α-amino acids and potential therapeutic applications

Carpio

Hernández

Ciangherotti

et al. 2018

Coordination Chemistry Reviews

102

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a b s t r a c tIn the last 30 years, since the discovery that vanadium is a cofactor found in certain enzymes of tunicates and possibly in mammals, different vanadium-based drugs have been developed targeting to treat different pathologies. So far, the in vitro studies of the insulin mimetic, antitumor and antiparasitic activity of certain compounds of vanadium have resulted in a great boom of its inorganic and bioinorganic chemistry. Chemical speciation studies of vanadium with amino acids under controlled conditions or, even in blood plasma, are essential for the understanding of the biotransformation of e.g. vanadium antidiabetic complexes at the physiological level, providing clues of their mechanism of action. The present article carries out a bibliographical research emphaticizing the chemical speciation of the vanadium with different amino acids and reviewing also some other important aspects such as its chemistry and therapeutical applications of several vanadium complexes.

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Section: Bioinorganic Implication and Application Of Vanadium Complexesmentioning

confidence: 99%

Section: Bioinorganic Implication and Application Of Vanadium Complexesmentioning

confidence: 99%

Vanadium: History, chemistry, interactions with α-amino acids and potential therapeutic applications

Carpio

Hernández

Ciangherotti

et al. 2018

Coordination Chemistry Reviews

102

View full text Add to dashboard Cite

show abstract

“…Moreover, the phosphatidylinositide-3-kinase (PI3K)/AKT signaling pathway has been reported to negatively regulate lipopolysaccharide (LPS)-induced acute inflammatory responses in vitro and in vivo (9,10). Previous studies have found that inhibition of the PI3K/AKT signaling pathway exerts a protective role in ALI (11 Naringenin, a flavonoid contained in citrus fruit, grapefruits and tomatoes, has been reported to exert multiple biological and pharmacological effects, such as anti-oxidative, anti-proliferative, anti-inflammatory and anti-tumor activities (12)(13)(14)(15). Previous studies have suggested that naringenin protected normal human bronchial epithelium against LPS-induced injury (16) and improved LPS-induced ALI in rats through its anti-inflammatory, anti-oxidant, anti-nitrosative and anti-apoptotic effects (17).…”

Section: Introductionmentioning

confidence: 99%

Naringenin ameliorates LPS-induced acute lung injury through its anti-oxidative and anti-inflammatory activity and by inhibition of the PI3K/AKT pathway

Zhao¹,

Shen

et al. 2017

Experimental and Therapeutic Medicine

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Abstract. The aim of the present study was to explore the effect of naringenin on lipopolysaccharide (LPS)-induced acute lung injury (ALI) in a mouse model, as well as the underlying mechanism. The animals were randomly assigned to four groups: PBS-treated healthy control (Control), LPS-induced ALI (LPS), vehicle-treated ALI (LPS + Vehicle), and naringenin-treated ALI (LPS + Nar) group. Naringenin (100 mg/kg) was administered orally for 4 consecutive days, starting 3 days prior to induction of ALI. The survival rates of mice, lung wet/dry weight ratios, lung injury score, protein levels of bronchoalveolar lavage fluid (BALF), lactate dehydrogenase (LDH) activity in the BALF, lung myeloperoxidase (MPO) activity, the number of infiltrated neutrophils and reactive oxygen species (ROS) levels (H 2 O 2 and malondialdehyde) were assessed. In addition, the serum and BALF levels of inflammatory cytokines [tumor necrosis factor-α, interleukin (IL)-1β, IL-6 and macrophage inflammatory protein 2] were determined, along with the total and the phosphorylated protein levels of phosphatidylinositol 3-hydroxy kinase (PI3K) and AKT in lung tissues. The results showed that naringenin pre-treatment significantly increased the survival rate, improved histopathologic changes, alleviated pulmonary edema and lung vascular leak, downregulated the levels of ROS and reduced neutrophil infiltration as well as the levels of inflammatory cytokines in the serum and BALF. Moreover, naringenin pre-treatment reduced the total and the phosphorylated protein levels of PI3K and AKT. The present study suggested that naringenin pre-treatment ameliorated LPS-induced ALI through its anti-oxidative and anti-inflammatory activity and by inhibition of the PI3K/AKT pathway in mice.

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“…VOSO 4 and NaVO 3 have been shown to inhibit rhabdomyosarcoma cell growth at similar concentrations that the ones we used (Dabros et al, ). Another +4 valence vanadium compound induce cell cycle arrest, caspase‐3/7 activation, mitochondrial potential on lung and breast cancer cell lines (Islas et al, ). Sodium orthovanadate also inhibits oral squamous, colon and kidney cancer cell proliferation and triggers apoptosis with similar concentrations as the one we report (Khalil & Jameson, ; Klein et al, ) in a manner similar to sodium metavanadate; nevertheless, these reports only mention as possible cause the crosstalk between different signaling phosphoproteins, possibly p53 through the ATM pathway (Suzuki et al, ).…”

Section: Discussionmentioning

confidence: 99%

“…The range of NaVO 3 and VOSO 4 concentrations were selected based on previous reports by different authors all of which used the same concentrations of vanadium compounds with valence (+4) and (+5) on the A549 lung cancer cell line (A549) and/or MCF7, MCF10, HTB44, DU145, Cal27, SKBR3 and RMS (Chien, Mak, & Huang, ; Dabros, Adamczyk, Ciurkot, & Kordowiak, ; Islas et al, ; Khalil & Jameson, ; Klein, Holko, Ligeza, & Kordowiak, ; Petanidis, Kioseoglou, Hadzopoulou‐Cladaras, & Salifoglou, ; Suzuki, Inageda, Nishitai, & Matsuoka, ). In previous unreported experiments, we observed that vanadium concentrations higher than 100 μ m induced a 60% or higher decrease in cell viability.…”

Section: Methodsmentioning

confidence: 99%

Vanadium compounds and cellular death mechanisms in the A549 cell line: The relevance of the compound valence

Guerrero-Palomo

Rendón-Huerta

Montaño

et al. 2018

J of Applied Toxicology

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Non‐small lung cell carcinoma has a high morbidity and mortality rates. The elective treatment for stage III and IV is cisplatinum that conveys serious toxic side effects. Vanadium compounds are metal molecules with proven antitumor activity that depends on its valence. Therefore, a better understanding of the mechanism of action of vanadium compounds is required. The aim of our study was to investigate the mechanisms of cell death induced by sodium metavanadate (NaVO3 [V(+5)]) and vanadyl sulfate (VOSO4 [(+4)]), both of which have reported apoptotic‐inducing activity. We exposed the A549 cell line to various concentrations (0‐100 μM) and to different exposure times to each compound and determined the cell viability and expression of caspases, reactive oxygen species (ROS) production, Bcl2, Bax, FasL and NO. Our results showed that neither compounds modified the basal expression of caspases or pro‐ and anti‐apoptotic proteins. The only change observed was the 12‐ and 14‐fold significant increase in ROS production induced by NaVO3 and VOSO4, respectively, at 100 μm concentrations after 48 hours. Our results suggest that classical apoptotic mechanisms are not related to the cell death induced by the vanadium compounds evaluated here, and showed that the higher ROS production was induced by the [(+4)] valence compound. It is possible that the difference will be secondary to its higher oxidative status and thus higher ROS production, which leads to higher cell damage. In conclusion, our results suggest that the efficacy of the cell death mechanisms induced by vanadium compounds differ depending on the valence of the compound.

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Insights into the mechanisms underlying the antitumor activity of an oxidovanadium(IV) compound with the antioxidant naringenin. Albumin binding studies

Cited by 38 publications

References 62 publications

Vanadium: History, chemistry, interactions with α-amino acids and potential therapeutic applications

Vanadium: History, chemistry, interactions with α-amino acids and potential therapeutic applications

Naringenin ameliorates LPS-induced acute lung injury through its anti-oxidative and anti-inflammatory activity and by inhibition of the PI3K/AKT pathway

Vanadium compounds and cellular death mechanisms in the A549 cell line: The relevance of the compound valence

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